Results 111 to 120 of about 18,455 (220)

Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls

BMC Cancer, 2019
Background For progressive metastatic medullary thyroid carcinoma (MTC), the available treatment options with tyrosine kinase inhibitors result in grade 3–4 adverse events in a large number of patients. Peptide Receptor Radionuclide Therapy (PRRT), which
Carolien M. Beukhof, Tessa Brabander, Francien H. van Nederveen, Marie-Louise F. van Velthuysen, Yolanda B. de Rijke, Leo J. Hofland, Gaston J. H. Franssen, Lideke A. C. Fröberg, Boen L. R. Kam, W. Edward Visser, Wouter W. de Herder, Robin P. Peeters   +11 more
doaj   +1 more source

Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals? [PDF]

, 2018
Purpose: Gallium-68 is a metallic positron emitter with a half-life of 68min that is ideal for the in vivo use of small molecules, such as [68Ga-DOTA,Tyr3]octreotide, in the diagnostic imaging of somatostatin receptor-positive tumours.
Antunes, P., Baum, R., Ginj, M., Maecke, H., Reubi, J., Waser, B., Zhang, H.   +6 more
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Cutaneous Neuroendocrine Metastases of Visceral Origin Responsive to Surgical Resection and Targeted Radionuclide Therapy

Case Reports in Dermatological Medicine
Neuroendocrine neoplasms (NENs) encompass a diverse range of biologically and behaviorally distinct epithelial malignancies that derive from neuroendocrine cells. These neoplasms are able to secrete a variety of bioactive amines or peptide hormones.
Eleanor Tung-Hahn, Ghassan El-Haddad, Jonathan Strosberg   +2 more
doaj   +1 more source

Targeted therapy in nuclear medicine—current status and future prospects [PDF]

, 2017
In recent years, a number of new developments in targeted therapies using radiolabeled compounds have emerged. New developments and insights in radioiodine treatment of thyroid cancer, treatment of lymphoma and solid tumors with radiolabeled monoclonal ...
Bodei, L., Brans, B., Giammarile, F., Luster, M., Maecke, H. R., Oyen, W. J. G., Tennvall, J.   +6 more
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Tolerability and outcomes of neuroendocrine tumors treated with PRRT and SBRT

Endocrine Oncology
There is interest in optimizing peptide receptor radionuclide therapy (PRRT) for the management of metastatic neuroendocrine neoplasms (NEN). The addition of stereotactic body radiation therapy (SBRT) may provide synergistic benefits by targeting ...
Jose E Nunez, Sylvia Ng, Hanbo Chen, Simron Singh, Julie Hallet, Calvin Law, Sten Myrehaug   +6 more
doaj   +1 more source

Potentially fatal crisis after 177Lu-DOTATATE therapy for paraganglioma: a case report with review of literature

Endocrine Journal
Pheochromocytoma/paraganglioma (PPGL) is a rare neuroendocrine tumor with metastatic potential. Peptide receptor radionuclide therapy with 177Lu-DOTATATE, a radiolabeled somatostatin analog, has been used for the treatment of somatostatin receptor ...
Aoki Tobimatsu, Kosuke Mukai, Yoshinari Obata, Kayako Isohashi, Kazuyuki Miyashita, Atsunori Fukuhara, Hiroki Kato, Iichiro Shimomura   +7 more
doaj   +1 more source

Comprehensive evaluation of a somatostatin-based radiolabelled antagonist for diagnostic imaging and radionuclide therapy [PDF]

, 2018
Purpose: Targeting of tumours positive for somatostatin receptors (sst) with radiolabelled peptides is of interest for tumour localization, staging, therapy follow-up and targeted radionuclide therapy.
Fani, Melpomeni, Maecke, Helmut, Reubi, Jean, Rivier, Jean, Schulz, Stefan, Wang, Xuejuan   +5 more
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Towards Effective Targeted Alpha Therapy for Neuroendocrine Tumours: A Review

Pharmaceuticals
This review article explores the evolving landscape of Molecular Radiotherapy (MRT), emphasizing Peptide Receptor Radionuclide Therapy (PRRT) for neuroendocrine tumours (NETs).
Paul M. D. Gape, Michael K. Schultz, Graeme J. Stasiuk, Samantha Y. A. Terry   +3 more
doaj   +1 more source

First Ex-Vivo Validation of a Radioguided Surgery Technique with beta- Radiation

, 2016
Purpose: A radio-guided surgery technique with beta- -emitting radio-tracers was suggested to overcome the effect of the large penetration of gamma radiation.
Bocci, V., Camillocci, E. Solfaroli, Carollo, A., Chiodi, G., Colandrea, M., Collamati, F., Cremonesi, M., Donnarumma, R., Faccini, R., Ferrari, M. E., Ferroli, P., Ghielmetti, F., Grana, C. M., Marafini, M., Morganti, S., Patanè, M., Pedroli, G., Pollo, B., Recchia, L., Russomando, A., Schiariti, M., Terracciano, C. Mancini, Toppi, M., Traini, G.   +23 more
core   +1 more source

Peptide Receptor Radionuclide Therapy with 177Lu-octreotate: clinical aspects [PDF]

, 2012
Somatostatin is a neuropeptide with a variety of functions and is produced in several tissues. The isoform somatostatin-14 (SS-14) is more biologically active than SS-28.
Essen, M. (Martijn) van
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