Results 161 to 170 of about 260,045 (204)
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Peptide toxins and potassium channels
1990After the first detailed description of the delayed outward potassium current in squid axon by Hodgkin and Huxley (1952) it took electrophysiologists more than 20 years to realize that in addition to it several types of K+ currents can exist in the same cell and that they have a number of functions including modulation of cell excitability and ...
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ChemInform Abstract: Engineering Cyclic Peptide Toxins
ChemInform, 2012AbstractReview: 47 refs.
Richard J. Clark, David J. Craik
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Pakistan journal of pharmaceutical sciences, 2006
A systematic investigation concerning uraemic toxicology has been made using modern analytical methods. The interest is especially focused on substances which are present in uraemic subjects in high concentrations, the so called "uraemic toxins". The samples from biological fluids have been screened with special regards to the presence of peptides and ...
S, Nagrani +4 more
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A systematic investigation concerning uraemic toxicology has been made using modern analytical methods. The interest is especially focused on substances which are present in uraemic subjects in high concentrations, the so called "uraemic toxins". The samples from biological fluids have been screened with special regards to the presence of peptides and ...
S, Nagrani +4 more
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Ribosomally Encoded Cyclic Peptide Toxins from Mushrooms
2012The cyclic peptide toxins of poisonous Amanita mushrooms are chemically unique among known natural products. Furthermore, they differ from other fungal cyclic peptides in being synthesized on ribosomes instead of by nonribosomal peptide synthetases. Because of their novel structures and biogenic origins, elucidation of the biosynthetic pathway of the ...
Jonathan D, Walton +2 more
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Enhancing the therapeutic potential of peptide toxins
Expert Opinion on Drug Discovery, 2017Peptide toxins are potent and often exquisitely selective probes of the structure and function of ion channels and receptors, and as such are of significant interest to the pharmaceutical and biotech industries as both therapeutic leads and pharmacological tools.
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Cellular effects of cyanobacterial peptide toxins
Toxicity Assessment, 1988AbstractPeptide toxins from the cyanobacteria Microcystic aeruginosa, Oscillatoria agardhii, Nodularia spumigena, and Anabaena flos‐aquae were isolated. Of these, only the cyclic peptide of Microcystis has been characterized structurally and toxicologically in detail.
J. E. Eriksson +4 more
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Functional Characterization of Peptide-Based Anthrax Toxin Inhibitors
Molecular Pharmaceutics, 2005We have identified an optimized peptide inhibitor that can be used to develop potent anthrax toxin therapeutics. Anthrax toxin, an essential virulence factor of Bacillus anthracis, elicits many of the symptoms associated with the disease, and is responsible for death.
Kunal, Gujraty +5 more
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Biomedical Importance of Marine Peptides/Toxins
2019Peptides transfer the information from cell to cell and regulate the life which is involved in biological signalling mechanism. Peptides consist of a combination of two or more amino acids which are linked together to form a polypeptide. Peptides are unable to enter into the cell since they are water soluble molecule.
Saravanan Ramachandran +1 more
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Spider peptide toxins as leads for drug development
Expert Opinion on Drug Discovery, 2007Venomous animals use a highly complex cocktails of proteins, peptides and small molecules to subdue and kill their prey. As such, venoms represent highly valuable combinatorial peptide libraries, displaying an extensive range of pharmacological activities, honed by natural selection.
Escoubas, Pierre, Bosmans, Frank
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Pore-forming peptides and protein toxins
2003PART 1 PORE-FORMING PROTEINS Staphylococcal Bicomponent Leucotoxins, Mechanisms of Action, Impact on Cells and Contribution to Virulence, Gilles Prevost, Gianfranco Menestrina, Didier A. Colin, Sandra Werner, Stephen Bronner, Mauro Dalla Serra, Lamin Baba Moussa, Manual Coraiola, Alain Gravet, and Henri Monteil The Formulation of Ion-permeable Channels
G Menestrina +2 more
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