Results 41 to 50 of about 939,420 (304)

A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila [PDF]

, 2014
Development of effective malaria vaccines is hampered by the problem of producing correctly folded Plasmodium proteins for use as vaccine components.
David R. Cavanagh, Hartmann Marcus W. W., Eleni-Muus Janna, Graeme J M Cowan, Ingo Aldag, Hartmann, Marcus W W, Samuel, Kay, Aldag Ingo, Samuel Kay, Alison M Creasey, Bockau, Ulrike, Cavanagh, David R, Alison M. Creasey, Creasey Alison M., Eleni-Muus, Janna, Cavanagh David R., Graeme J. M. Cowan, Cowan, Graeme J M; id_orcid, Ulrike Bockau, David R Cavanagh, Creasey, Alison M, Kay Samuel, Cowan Graeme J. M., Aldag, Ingo, Janna Eleni-Muus, Marcus W. W. Hartmann, Marcus W W Hartmann, Bockau Ulrike   +27 more
core   +2 more sources

The Peptide Vaccine Combined with Prior Immunization of a Conventional Diphtheria-Tetanus Toxoid Vaccine Induced Amyloid β Binding Antibodies on Cynomolgus Monkeys and Guinea Pigs

Journal of Immunology Research, 2015
The reduction of brain amyloid beta (Aβ) peptides by anti-Aβ antibodies is one of the possible therapies for Alzheimer’s disease. We previously reported that the Aβ peptide vaccine including the T-cell epitope of diphtheria-tetanus combined toxoid (DT ...
Akira Yano, Kaori Ito, Yoshikatsu Miwa, Yoshito Kanazawa, Akiko Chiba, Yutaka Iigo, Yoshinori Kashimoto, Akira Kanda, Shinji Murata, Mitsuhiro Makino   +9 more
doaj   +1 more source

Liposomal Formulations of a Polyleucine–Antigen Conjugate as Therapeutic Vaccines against Cervical Cancer

Pharmaceutics, 2023
Human papilloma virus (HPV) is responsible for all cases of cervical cancer. While prophylactic vaccines are available, the development of peptide-based vaccines as a therapeutic strategy is still under investigation.
Farrhana Z. Firdaus, Stacey Bartlett, Waleed M. Hussein, Lantian Lu, Quentin Wright, Wenbin Huang, Ummey J. Nahar, Jieru Yang, Mattaka Khongkow, Margaret Veitch, Prashamsa Koirala, Uracha R. Ruktanonchai, Michael J. Monteiro, Jazmina L. Gonzalez Cruz, Rachel J. Stephenson, James W. Wells, Istvan Toth, Mariusz Skwarczynski   +17 more
doaj   +1 more source

Preferential amplification of CD8 effector-T cells after transcutaneous application of an inactivated influenza vaccine: a randomized phase I trial [PDF]

, 2010
Background: Current conventional vaccination approaches do not induce potent CD8 T-cell responses for fighting mostly variable viral diseases such as influenza, avian influenza viruses or HIV.
van der Werf, Sylvie, Christine Katlama, Annika Vogt, Dominique Costagliola, Katlama, Christine, Sabrina Hadam, Behazine Combadière, Sterry, Wolfram, Vogt, Annika, Costagliola, Dominique, Autran, Brigitte, Blume-Peytav, Ulrike, Brice Mahé, Wolfram Sterry, Bonduelle, Olivia, Shlomo Staszewski, Ulrike Blume-Peytavi, Brigitte Autran, Olivia Bonduelle, Blume-Peytavi, Ulrike, Combadière, Behazine, Mahé, Brice, Hadam, Sabrina, Schaefer, Hans, Staszewski, Shlomo, Hans Schaefer, Sylvie van der Werf   +26 more
core   +2 more sources

Improving therapeutic HPV peptide-based vaccine potency by enhancing CD4+ T help and dendritic cell activation

Journal of Biomedical Science, 2010
Background Effective vaccination against human papillomavirus (HPV) represents an opportunity to control cervical cancer. Peptide-based vaccines targeting HPV E6 and/or E7 antigens while safe, will most likely require additional strategies to enhance the
Hung Chien-Fu, Pang Xiaowu, Monie Archana, Wu Chao-Yi, Wu T-C   +4 more
doaj   +1 more source

Plasmodium vivax antigen discovery based on alpha-helical coiled coil protein motif [PDF]

, 2014
Protein α-helical coiled coil structures that elicit antibody responses, which block critical functions of medically important microorganisms, represent a means for vaccine development.
Kajava, Andrey V., Catherine Habel (587966), Ingrid Felger (92160), Andrey V. Kajava (87242), Myriam Arévalo-Herrera (2576233), Herrera, Sócrates, Catherine Habel, Felger, Ingrid, Corradin, Giampietro, Angélica Castellanos (587967), Moret, Remy, Ingrid Felger, Giampietro Corradin (27387), Sócrates Herrera, Angélica Castellanos, Myriam Arévalo-Herrera, Catherine Servis (273314), Mary Lopez-Perez (123279), Mary Lopez-Perez, Habel, Catherine, Céspedes, Nora, Servis, Catherine, Andrey V Kajava, Sócrates Herrera (2576236), Castellanos, Angélica, Arévalo-Herrera, Myriam, Giampietro Corradin, Remy Moret (587968), Nora Céspedes (587965), Remy Moret, Lopez-Perez, Mary, Catherine Servis, Nora Céspedes   +32 more
core   +2 more sources

Microsomal membranes from antigen presenting cells present antigenic peptides to T cells: a novel approach in vaccine development. [PDF]

, 2010
PhDThe study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective vaccines are potent in generating neutralizing antibody responses.
Sofra, Vasiliki
core   +4 more sources

Adenoviral-vectored neoantigen vaccine augments hyperexpanded CD8+ T cell control of tumor challenge in mice

Journal for ImmunoTherapy of Cancer
Background Neoantigens are promising immunogens for cancer vaccines and are often delivered as adjuvanted peptide vaccines. Adenoviral (Ad) vectors have been shown to induce strong CD8+ T cell responses as vaccines against SARS-CoV-2, Ebola, and Zika ...
David Li, Gabriel Dagotto, Alessandro Colarusso, Robert C Patio, Tochi Anioke, Victoria Giffin, Ruoran Guan, Trisha Anand, Esther Mbiwan, Malika Aid, Dan Barouch   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Development of a bivalent conjugate vaccine candidate against rotaviral diarrhea and tuberculosis using polysaccharide from Mycobacterium tuberculosis conjugated to ΔVP8* protein from rotavirus

, 2021
Conjugation of carbohydrate antigens with a carrier protein is a clinically proven strategy to overcome the poor immunogenicity of bacterial polysaccharide.
조상래
core   +1 more source