Results 21 to 30 of about 939,420 (304)

Enhancement of antitumor effect by peptide vaccine therapy in combination with anti-CD4 antibody: Study in a murine model

Biochemistry and Biophysics Reports, 2016
Purpose: The clinical efficacy of cancer peptide vaccine therapy is insufficient. To enhance the anti-tumor effect of peptide vaccine therapy, we combined this therapy with an anti-CD4 mAb (GK1.5), which is known to deplete CD4+ cells, including ...
Norihiro Fujinami, Toshiaki Yoshikawa, Yu Sawada, Manami Shimomura, Tatsuaki Iwama, Shiori Sugai, Shigehisa Kitano, Yasushi Uemura, Tetsuya Nakatsura   +8 more
doaj   +1 more source

Peptide Vaccines for Leishmaniasis [PDF]

Frontiers in Immunology, 2018
Due to an increase in the incidence of leishmaniases worldwide, the development of new strategies such as prophylactic vaccines to prevent infection and decrease the disease have become a high priority. Classic vaccines against leishmaniases were based on live or attenuated parasites or their subunits.
Rory C. F. De Brito, Rory C. F. De Brito, Jamille M. De O. Cardoso, Levi E. S. Reis, Levi E. S. Reis, Joao F. Vieira, Fernando A. S. Mathias, Bruno M. Roatt, Bruno M. Roatt, Bruno M. Roatt, Rodrigo Dian D. O. Aguiar-Soares, Jeronimo C. Ruiz, Jeronimo C. Ruiz, Daniela de M. Resende, Daniela de M. Resende, Alexandre B. Reis, Alexandre B. Reis, Alexandre B. Reis   +17 more
openaire   +3 more sources

Assessment of Safety and Prophylactic Efficacy of the EpiVacCorona Peptide Vaccine for COVID-19 Prevention (Phase III)

Vaccines, 2023
The State Research Center of Virology and Biotechnology “VECTOR” of the Federal Service for the Oversight of Consumer Protection and Welfare (Rospotrebnadzor) has developed the peptide-based EpiVacCorona vaccine, which is the first synthetic peptide ...
Alexander B. Ryzhikov, Evgeny A. Ryzhikov, Marina P. Bogryantseva, Svetlana V. Usova, Elena A. Nechaeva, Elena D. Danilenko, Stepan A. Pyankov, Andrey S. Gudymo, Anastasiya A. Moiseeva, Galina S. Onkhonova, Oleg V. Pyankov, Ekaterina S. Sleptsova, Nikita V. Lomakin, Veronika S. Vasilyeva, Mikhail V. Tulikov, Vitaly G. Gusarov, Andrey A. Pulin, Maria A. Balalaeva, Svetlana B. Erofeeva, Stanislav A. Terpigorev, Olga A. Rychkova, Ivan M. Petrov, Viktoriia Y. Delian, Vladimir V. Rafalskiy, Sergey V. Tyranovets, Elena V. Gavrilova, Rinat A. Maksyutov   +26 more
doaj   +1 more source

Virosome-formulated Plasmodium falciparum AMA-1 & CSP derived peptides as malaria vaccine: randomized phase 1b trial in semi-immune adults & children. [PDF]

, 2011
BACKGROUND\ud \ud This trial was conducted to evaluate the safety and immunogenicity of two virosome formulated malaria peptidomimetics derived from Plasmodium falciparum AMA-1 and CSP in malaria semi-immune adults and children.\ud \ud METHODS\ud \ud The
Machunda, E.B., Gerd Pluschke, Abdulla, Salim, Tanner, M., Daubenberger Claudia, Mpina, M., Stoffel, Sabine Alexandra, Daubenberger, C., Stoffel, S.A., Cech, P.G., Daubenberger, Claudia, Zurbriggen Rinaldo, Abdulla, S., Cech Patrick Georges, Blaise Genton, Cech, Patrick Georges, Mwanajaa Shomari Abdallah, Westerfeld Nicole, Zurbriggen, R., Stoffel Sabine Alexandra, Westerfeld, N., Tanner Marcel, Abdallah Mwanajaa Shomari, Abdulla Salim, Patrick Georges Cech, Genton, B., Pluschke, Gerd, Claudia Daubenberger, Mpina, Maxmillian, Aebi, T., Salim Abdulla, Zurbriggen, Rinaldo, Rinaldo Zurbriggen, Westerfeld, Nicole, Sabine Alexandra Stoffel, Mpina Maxmillian, Thomas Aebi, Marcel Tanner, Pluschke, G., Tanner, Marcel, Genton, Blaise, Nicole Westerfeld, Abdallah, M.S., Pluschke Gerd, Aebi, Thomas, Machunda Ester Barnabas, Genton Blaise, Ester Barnabas Machunda, Machunda, Ester Barnabas, Abdallah, Mwanajaa Shomari, Maxmillian Mpina, Aebi Thomas   +51 more
core   +2 more sources

Unconjugated Multi-Epitope Peptides Adjuvanted with ALFQ Induce Durable and Broadly Reactive Antibodies to Human and Avian Influenza Viruses

Vaccines, 2023
An unconjugated composite peptide vaccine targeting multiple conserved influenza epitopes from hemagglutinin, neuraminidase, and matrix protein and formulated with a safe and highly potent adjuvant, Army Liposome formulation (ALFQ), generated broad and ...
Nimisha Rikhi, Clara J. Sei, Mangala Rao, Richard F. Schuman, Kellie A. Kroscher, Gary R. Matyas, Kevin Muema, Camille Lange, Aba Assiaw-Dufu, Elizabeth Hussin, Ousman Jobe, Carl R. Alving, Gerald W. Fischer   +12 more
doaj   +1 more source

Satisfactory safety and immunogenicity of MSP3 malaria vaccine candidate in Tanzanian children aged 12-24 months. [PDF]

, 2009
BACKGROUND: Development and deployment of an effective malaria vaccine would complement existing malaria control measures. A blood stage malaria vaccine candidate, Merozoite Surface Protein-3 (MSP3), produced as a long synthetic peptide, has been shown ...
Gesase Samwel, Druilhe, Pierre, Chilengi Roma, Roma Chilengi, Method D Segeja, Seth, Misago, Msham Salum, Francis Filbert, Lemnge, Martha, Samwel Sembuche, Salum Msham, Noor Ramadhani, Cousens Simon, Sembuche, Samwel, Minja Daniel, Martha Lemnge, Simon Cousens, Samuel Bosomprah, Chilengi, Roma, Samwel Gesase, Lusingu, John PA, Gesase, Samwel, John PA Lusingu, Rutta, Acleus, Bosomprah Samuel, Cousens, Simon, Ramadhani Noor, Acleus Rutta, Pierre Druilhe, Seth Misago, Segeja Method D, Minja, Daniel, Msham, Salum, Druilhe Pierre, Daniel Minja, Francis, Filbert, Noor, Ramadhani, Lemnge Martha, Bosomprah, Samuel, Lusingu John PA, Rutta Acleus, Misago Seth, Segeja, Method D, Sembuche Samwel, Filbert Francis   +44 more
core   +1 more source

Diversity and recognition efficiency of T cell responses to cancer. [PDF]

PLoS Medicine, 2004
Melanoma patients vaccinated with tumor-associated antigens frequently develop measurable peptide-specific CD8+ T cell responses; however, such responses often do not confer clinical benefit. Understanding why vaccine-elicited responses are beneficial in
Tor B Stuge, Susan P Holmes, Sahdev Saharan, Andrea Tuettenberg, Mario Roederer, Jeffrey S Weber, Peter P Lee   +6 more
doaj   +1 more source

Developing an Effective Peptide-Based Vaccine for COVID-19: Preliminary Studies in Mice Models

Viruses, 2022
Coronavirus disease 2019 (COVID-19) has caused massive health and economic disasters worldwide. Although several vaccines have effectively slowed the spread of the virus, their long-term protection and effectiveness against viral variants are still ...
Haiqiang Yang, Jessica Cao, Xiaoyang Lin, Jingwen Yue, Tarek Zieneldien, Janice Kim, Lianchun Wang, Jianmin Fang, Ruo-Pan Huang, Yun Bai, Kevin Sneed, Chuanhai Cao   +11 more
doaj   +1 more source

Synthetic peptide vaccines [PDF]

Biomeditsinskaya Khimiya, 2010
This review considers the stages of the development of synthetic peptide vaccines against infectious agents, novel approaches and technologies employed in this process, including bioinformatics, genomics, proteomics, large-scale peptide synthesis, high-throughput screening methods, the use of transgenic animals for modelling human infections.
A A, Moĭsa, E F, Kolesanova
openaire   +4 more sources

Enzyme-linked immunosorbent assay using a virus type-specific peptide based on a subdomain of envelope protein e(rns) for serologic diagnosis of pestivirus infections in swine [PDF]

, 2001
Peptides deduced from the C-terminal end (residues 191 to 227) of pestivirus envelope protein Erns were used to develop enzyme-linked immunosorbent assays (ELISAs) to measure specifically antibodies against different types of pestiviruses.
Langedijk, J.P., Smit, J.A., de, Meloen, R.H., Middel, W.G., Kramps, J.A., de Smit, J.A.   +5 more
core   +1 more source