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The Peptide Vaccine of the Future [PDF]

Molecular and Cellular Proteomics, 2021
The approach of peptide-based anticancer vaccination has proven the ability to induce cancer-specific immune responses in multiple studies for various cancer entities. However, clinical responses remain so far limited to single patients and broad clinical applicability was not achieved.
Juliane Sarah Walz, Annika Nelde, Hans-Georg Rammensee   +2 more
exaly   +3 more sources

Multi-Epitopic Peptide Vaccine Against Newcastle Disease Virus: Molecular Dynamics Simulation and Experimental Validation [PDF]

Vaccines
Background: Newcastle disease virus (NDV) is a highly contagious and economically devastating pathogen affecting poultry worldwide, leading to significant losses in the poultry industry.
Muhammad Tariq Zeb, Elise Dumont, Muhammad Tahir Khan, Aroosa Shehzadi, Irshad Ahmad   +4 more
doaj   +2 more sources

Development and assessment of a peptide vaccine against ovarian cancer utilizing nanoliposomes loaded with P53, WT1, and CA125 epitopes [PDF]

Journal of Ovarian Research
This study aimed to design, synthesize, and evaluate a peptide vaccine based on nanoliposomes loading multi-epitopes (PVNLME) of P53, WT1, and CA125.
Fatemeh Shariati, Mehrdad Hashemi, Maryam Peyvandi, Ali Jebali, Maliheh Entezari   +4 more
doaj   +2 more sources

Case Report: A Multi-Peptide Vaccine Targeting Individual Somatic Mutations Induces Tumor Infiltration of Neoantigen-Specific T Cells in a Patient with Metastatic Colorectal Cancer [PDF]

Vaccines
Background/Objectives: Fully personalized peptide vaccines targeting tumor-specific mutations are a promising treatment option for patients in an adjuvant but also advanced/metastatic disease situation in addition to non-personalized standard therapies ...
Armin Rabsteyn, Henning Zelba, Borong Shao, Lisa Oenning, Christina Kyzirakos, Simone Kayser, Tabea Riedlinger, Johannes Harter, Magdalena Feldhahn, Dirk Hadaschik, Florian Battke, Veit Scheble, Alfred Königsrainer, Saskia Biskup   +13 more
doaj   +2 more sources

Design and Preliminary Immunogenicity Evaluation of Nipah Virus Glycoprotein G Epitope-Based Peptide Vaccine in Mice [PDF]

Vaccines
Background: The emergence of several paramyxoviruses, including Nipah virus (NiV), makes continued efforts in vaccine development as part of pandemic preparedness efforts necessary.
Seungyeon Kim, Rochelle A. Flores, Seo Young Moon, Seung Yun Lee, Bujinlkham Altanzul, Jiwon Baek, Eun Bee Choi, Heeji Lim, Eun Young Jang, Yoo-kyoung Lee, In-Ohk Ouh, Woo H. Kim   +11 more
doaj   +2 more sources

Intramuscular injection of a mixture of COVID-19 peptide vaccine and tetanus vaccine in horse induced neutralizing antibodies against authentic virus of SARS-CoV-2 Delta variant

Vaccine: X, 2022
Peptide vaccine is not effective due to its low immunogenicity. To improve the efficacy of peptide vaccine against COVID-19, a novel method was developed by mixing a COVID-19 peptide vaccine with a tetanus vaccine.
Weiwen Deng, Raymond W. Sweeney
doaj   +1 more source

Immune Enhancement by the Tetra-Peptide Hydrogel as a Promising Adjuvant for an H7N9 Vaccine against Highly Pathogenic H7N9 Virus

Vaccines, 2022
Background: Short peptide hydrogel was reported as a possible adjuvant for vaccines. In order to evaluate whether the Tetra-Peptide Hydrogel can be a promising adjuvant for an H7N9 vaccine against the highly pathogenic H7N9 virus, we conducted this study.
Xiaoxin Wu, Songjia Tang, Zhehua Wang, Xiaoyun Ma, Lingjian Zhang, Fen Zhang, Lanlan Xiao, Shuai Zhao, Qian Li, Ying Wang, Qingjing Wang, Keda Chen   +11 more
doaj   +1 more source

Peptides for Vaccine Development [PDF]

ACS Applied Bio Materials, 2022
This review discusses peptide epitopes used as antigens in the development of vaccines in clinical trials as well as future vaccine candidates. It covers peptides used in potential immunotherapies for infectious diseases including SARS-CoV-2, influenza, hepatitis B and C, HIV, malaria, and others.
openaire   +2 more sources

Comprehensive evaluation of the safety and immunogenicity of a gene-deleted variant pseudorabies virus attenuated vaccine

Veterinary Research, 2022
Pseudorabies virus (PRV) variant infections have caused a substantial economic impact on swine production in the absence of new powerful candidate vaccines.
Ling Li, Yongfeng Du, Yanbin Zhang, Pengyu Li, Xinyue Liu, Xin Zhang, Jing Li, Tong Zhang, Xin Li, Dong Xiao, Peng Liu, Peng Qi, Jin Xiao   +12 more
doaj   +1 more source

Supramolecular co-assembly of self-adjuvanting nanofibrious peptide hydrogel enhances cancer vaccination by activating MyD88-dependent NF-κB signaling pathway without inflammation

Bioactive Materials, 2021
Peptide vaccine targeting tumor-specific antigens is a promising cancer treatment regimen. However, peptide vaccines are commonly low-immunogenic, leading to suboptimal antitumor T-cell responses.
Qi Su, Huijuan Song, Pingsheng Huang, Chuangnian Zhang, Jing Yang, Deling Kong, Weiwei Wang   +6 more
doaj   +1 more source