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In pregnant women, Plasmodium falciparum-infected red blood cells adhere to the placenta via the parasite protein VAR2CSA. Two vaccine candidates based on VAR2CSA are currently in clinical trials; however, these candidates failed to elicit strain ...
Catherine J. Mitran +3 more
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An escherichia coli vaccine co-expressing listeriolysin-O and tumour antigen in cancer immunotherapy and the mechanisms of immune regulation [PDF]
PhDSome recombinant bacterial strains have been shown to be very efficient in experimental therapies against cancer in rodent models. Amongst them is an E. coli that expresses the Listeriolysin-O protein (LLO) and a model tumour antigen ovalbumin (OVA)
Dai, Ming-Shen
core +4 more sources
The progress of peptide vaccine clinical trials in gynecologic oncology
Peptide vaccine are a type of immunotherapy that are synthesized according to the amino acid sequence of known or predicted tumor antigen epitopes. They are safe and well tolerated and have shown exciting results in gynecologic oncology.
Mi Tang +5 more
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Objectives Spondyloarthritis (SpA) is known as series of immune-mediated inflammatory disease of the axial and peripheral joints. Human leucocyte antigen (HLA)-B27 is a genetic risk factor for SpA. Recent evidence suggests that the interleukin −17 (IL17)
Tetsuya Tomita +16 more
doaj +1 more source
A novel M2e based flu vaccine formulation for dogs. [PDF]
BACKGROUND:The USA 2004 influenza virus outbreak H3N8 in dogs heralded the emergence of a new disease in this species. A new inactivated H3N8 vaccine was developed to control the spread of the disease but, as in humans and swine, it is anticipated that ...
Denis Leclerc +5 more
doaj +1 more source
Pathogenicity and immune modulation of porcine circovirus 3
Porcine circoviruses (PCVs) are members of the genus Circovirus of the family Circoviridae, and four species of PCVs have been discovered and named PCV1–PCV4, respectively.
Dengjin Chen, Lei Zhang, Shengkui Xu
doaj +1 more source
Summary: Efficient delivery of subunit vaccines to dendritic cells (DCs) is necessary to improve vaccine efficacy, because the vaccine antigen alone cannot induce sufficient protective immunity.
Teppei Matsuda +10 more
doaj +1 more source
Human cytomegalovirus (HCMV) infection is prevalent worldwide, and there is currently no licenced HCMV vaccine to control it. Therefore, developing an effective HCMV vaccine is a significant priority.
Shuyun Zhang +9 more
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Development of a malaria vaccine candidate based on virosome technology [PDF]
Malaria is an infectious disease caused by protozoan pathogens of the genus Plasmodium. The most important species affecting humans is P. falciparum transmitted by the bite of female Anopheles mosquitoes during a blood meal.
Okitsu, Shinji Lukas
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Enhanced cross-recognition of SARS-CoV-2 Omicron variant by peptide vaccine-induced antibodies
Current vaccines against SARS-CoV-2, based on the original Wuhan sequence, induce antibodies with different degrees of cross-recognition of new viral variants of concern.
Belén Aparicio +24 more
doaj +1 more source

