Results 31 to 40 of about 939,420 (304)

A deeper mining on the protein composition of VA-MENGOC-BC®: An OMV-based vaccine against N. meningitidis serogroup B and C

Human Vaccines & Immunotherapeutics, 2017
The protein composition of an Outer Membrane Vesicle (OMV) preparation that constitutes the active pharmaceutical ingredient of VA-MENGOC-BC®, an effective vaccine against Neisseria meningitidis serogroups B, and C is presented.
Yordanka Masforrol, Jeovanis Gil, Darien García, Jesús Noda, Yassel Ramos, Lázaro Betancourt, Osmany Guirola, Sonia González, Boris Acevedo, Vladimir Besada, Osvaldo Reyes, Luis Javier González   +11 more
doaj   +1 more source

SAG4 DNA and Peptide Vaccination Provides Partial Protection against T. gondii Infection in BALB/c Mice

Frontiers in Microbiology, 2017
Toxoplasma gondii can lead to congenital infections in human. Surface antigen protein 4 (SAG4) of T. gondii is a potential stimulator for humoral and cellular immune responses. In the present study, a DNA vaccine encoding SAG4 from T.
Jian Zhou, Lin Wang
doaj   +1 more source

The SARS-CoV-2 spike residues 616/644 and 1138/1169 delineate two antibody epitopes in COVID-19 mRNA COMINARTY vaccine (Pfizer/BioNTech)

Scientific Reports, 2022
The newly identified coronavirus SARS-CoV-2 is responsible for the worldwide pandemic COVID-19. Considerable efforts have been devoted for the development of effective vaccine strategies against COVID-19.
Jessica Andries, Wildriss Viranaicken, Colette Cordonin, Charline Herrscher, Cynthia Planesse, Bénédicte Roquebert, Marie Lagrange-Xelot, Chaker El-Kalamouni, Olivier Meilhac, Patrick Mavingui, David Couret, Gilles Gadea, Philippe Despres   +12 more
doaj   +1 more source

Peptide-Based Immunotherapeutics and Vaccines [PDF]

Journal of Immunology Research, 2014
Vaccination produces profound and long lasting modifications in the adaptive immune system comprising T and B cells. Vaccines are curative not mere palliative remedies and thus vaccination is the most efficient method to prevent and to lesser extent treat infectious diseases, cancer, and allergy conditions. Currently, there is an increasing interest in
Pedro A. Reche, Enrique Fernandez-Caldas, Darren R. Flower, Masha Fridkis-Hareli, Yoshihiko Hoshino   +4 more
openaire   +4 more sources

Humoral and cell-mediated immunity to MSP3 peptides in adults immunized with MSP3 in malaria endemic area, Burkina Faso. [PDF]

, 2009
We performed a single-blind, randomized phase 1 trial of the long synthetic peptide (LSP) of merozoite surface protein-3 (MSP3) in adults living in Burkina Faso.
A. B. TIONO, O. LEROY, Sirima, SB, Cousens, S, A. GANSANE, Diarra, A, Gansane, A, Soulama, I, Nebie, I, Konate, AT, A. OUEDRAOGO, I. SOULAMA, A. DIARRA, Leroy, O, I. NEBIE, A. T. KONATE, Tiono, AB, Ouedraogo, A, S. COUSENS, S. B. SIRIMA   +19 more
core   +1 more source

Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV.

PLoS Pathogens, 2018
Eliciting broadly neutralizing antibodies (bnAbs) targeting envelope (Env) is a major goal of HIV vaccine development, but cross-clade breadth from immunization has only sporadically been observed.
Adam S Dingens, Priyamvada Acharya, Hugh K Haddox, Reda Rawi, Kai Xu, Gwo-Yu Chuang, Hui Wei, Baoshan Zhang, John R Mascola, Bridget Carragher, Clinton S Potter, Julie Overbaugh, Peter D Kwong, Jesse D Bloom   +13 more
doaj   +1 more source

Synthetic Long Peptide Influenza Vaccine Containing Conserved T and B Cell Epitopes Reduces Viral Load in Lungs of Mice and Ferrets. [PDF]

PLoS ONE, 2015
Currently licensed influenza vaccines mainly induce antibodies against highly variable epitopes. Due to antigenic drift, protection is subtype or strain-specific and regular vaccine updates are required.
S K Rosendahl Huber, M G M Camps, R H J Jacobi, J Mouthaan, H van Dijken, J van Beek, F Ossendorp, J de Jonge   +7 more
doaj   +1 more source

Design and analysis of peptide based nanoparticles [PDF]

, 2008
Viruses are naturally formed bionanoparticles (BNPs), ranging in size from 22-150 nm. Remarkably, small viruses are composed of one single protein chain folding into a capsid structure with icosahedral symmetry.
Raman, Senthilkumar
core   +1 more source

Immunological consequences of using three different clinical/laboratory techniques of emulsifying peptide-based vaccines in incomplete Freund's adjuvant

Journal of Translational Medicine, 2006
Incomplete Freund's adjuvant (IFA) serves as a carrier for water-in-oil emulsion (W/O) vaccines. The stability of such emulsions greatly affects vaccine safety and efficacy since continued presence of antigen depots at lymphoid organs releasing low-level
Kast W Martin, Weber Jeffrey S, Higgins Sean A, Koh Yi T   +3 more
doaj   +1 more source

Induction of humoral immune responses and inhibition of metastasis in mice by a VEGF peptide-based vaccine [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Blocking of vascular endothelial growth factor (VEGF) plays a pivotal role in inhibition of metastasis and is a target for development of anti-angiogenic agents.
Faezeh Soltanpour Gharibdousti, Banafsheh Fazeli Delshad, Reza Falak, Nasrin Shayanfar, Mazdak Ganjalikhani Hakemi, Alireza Andalib, Gholamali Kardar   +6 more
doaj   +1 more source