Results 171 to 180 of about 202,644 (307)

Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase. [PDF]

Nat Prod Bioprospect
Hellinger R, Schwarz P, Dieringer J, Ebermann C, Jadhav KB, Muttenthaler M, Gruber CW.   +6 more
europepmc   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Functional Effects of Cyclization on Li1 Peptide Activity against Metacyclic <i>Leishmania amazonensis</i> Internalization. [PDF]

ACS Omega
Reis TC, Yagi ACL, Velásquez AMA, Dias Ramos AL, Costa Coelho NC, Cilli EM, Graminha MAS.   +6 more
europepmc   +1 more source

Three‐Dimensional Ovary Model to Improve and Study Murine Follicle Growth

Advanced Healthcare Materials, EarlyView.
To develop new methods for fertility preservation in women, novel culture systems for small follicles need to be established. In this work, a poly(ethylene glycol) based scaffold, with appropriate mechanical and bioactive features to support mouse follicle and ovary cell growth is developed, and the formed cell‐follicle interactions are visualized ...
Mira Jacobs, Valon Gllareva, Lukas Moser, Silvia Pravato, Eric Mora Pimentel, Brigitte Leeners, Martin Ehrbar   +6 more
wiley   +1 more source

<i>In Silico</i> Design and Analysis of a Novel Ranibizumab-derived Peptide against the Vascular Endothelial Growth Factor. [PDF]

J Ophthalmic Vis Res
Afarid M, Baghban R, Ghasemali S, Zamani J, Zareei A.   +4 more
europepmc   +1 more source

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Isothiocyanate-mediated cyclization of phage-displayed peptides enables discovery of macrocyclic binders. [PDF]

Sci Adv
Bai L, Dan T, Cheng P, Yang X, Xiang H, Zhai W, Chen Y, Huang R, Wang Q, Li K, Gao J, Lei X.   +11 more
europepmc   +1 more source

Enhanced Human Antigen‐Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells

Advanced Healthcare Materials, EarlyView.
We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham, Marlon de Gast, Liubov Babii, Sabine Kruijer, Theo M. Bestebroer, Mathilde Richard, Mathieu Claireaux, S. Marieke van Ham, Jelle de Wit, Cécile A. C. M. van Els, Anja ten Brinke, Marit J. van Gils   +11 more
wiley   +1 more source

Selectivity Modulation of Small Cationic Membrane-Active Cyclic Peptides with Broad-Spectrum Activity against Bacteria and Fungi. [PDF]

J Med Chem
Lohan S, Tiwari RK, Maslennikov I, Das Gupta K, Singh S, Parang K.   +5 more
europepmc   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source