Identification of Antibacterial Cyclic Peptides with a High-Throughput Cell-Based Dropout Screen. [PDF]
J Am Chem SocWindeln LM +6 more
europepmc +1 more source
Advances in Bio‐Integrated Edge Computing Systems for Smart and Connected Health
Advanced Materials, EarlyView.This review explores advances in bio‐integrated edge computing for healthcare, focusing on co‐designing computing, sensing, and energy strategies to overcome integration and power challenges for optimized, decentralized operation. ABSTRACT Recent advances in bio‐integrated healthcare technologies have enabled continuous, high‐resolution monitoring and ...
Gyuwon Kim +4 more
wiley +1 more source
Fragment Coverage: Unified Visualization and Quantitative Assessment of MS/MS Fragmentation Supports Metabolite Identification in Macromolecule Drug Metabolism Studies. [PDF]
Rapid Commun Mass SpectromCifuentes P +3 more
europepmc +1 more source
Biomass DNA: An Emerging Building Block for Advanced Materials
Advanced Materials, EarlyView.Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley +1 more source
The Coalescence of a "Happy Accident" and an In Vitro Structure-Activity Panel: Increasing the Potency of a Cyclic Peptide Inhibitor to Thrombosis Initiation. [PDF]
ChemMedChemBarreto GM +8 more
europepmc +1 more source
Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction
Advanced Materials, EarlyView.The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu +2 more
wiley +1 more source
Anticancer Peptides: Design Principles, Translational Bottlenecks, and Emerging Opportunities. [PDF]
MoleculesDi ME, Di YP.
europepmc +1 more source
Interface Dynamics in Biomolecular Condensates by High‐Speed AFM
Advanced Materials Interfaces, EarlyView.High‐speed atomic force microscopy provides nanoscale structural dynamics at the liquid interface of biomolecular condensates, key elements in several cellular pathways. By addressing the challenges of low surface tension and condensate‐induced instabilities, we achieve nanometer spatial and sub‐second temporal resolution, revealing structural ...
Andreas Santamaria +6 more
wiley +1 more source
Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development. [PDF]
Angew Chem Int Ed EnglSharma KK +5 more
europepmc +1 more source
Advanced Materials Interfaces, EarlyView.Hemagglutinin precomplexation with antibodies (Abs) results in broad valency distributions, though it increases the total avidity from mM to nM to high nM. The valency distribution and the orientation of multivalent HA‐Ab complexes determine the extent of binding to different types of assays, whether the receptors are displayed in 2D or 3D.
Daniel Y. E. L. Tambuwun +8 more
wiley +1 more source