Results 191 to 200 of about 100,338 (264)

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Profiling Endogenous Opioid Peptide Release from Adrenal Chromaffin Cells. [PDF]

ACS Chem Neurosci
Berger JM, Denison JD, De Alwis AC, Sumner HP, McCarty GS, Romanova EV, Sweedler JV, Sombers LA.   +7 more
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Cyclic Peptide-Polymer Conjugate Characterization Using 193 nm Ultraviolet Photodissociation Tandem Mass Spectrometry. [PDF]

Anal Chem
Morgan TE, Theisen A, Ellacott S, Haris A, Wootton CA, Rho JY, Barrow MP, Bristow AWT, Perrier S, O'Connor PB.   +9 more
europepmc   +1 more source

De novo cyclic peptides allow visualisation of the monomeric and functional amyloid conformations of the kinase RIPK3. [PDF]

Biochem J
Buchanan JA, Lavidis O, Shields N, Harrison K, Nguyen HT, Payne RJ, Passioura T, Steain M, Sunde M.   +8 more
europepmc   +1 more source

Development of an Optimized CXCR4-Targeting Theranostic Pair. [PDF]

J Nucl Med
Kwon D, Bloise I, Zhang Z, Colpo N, Wilson R, Tan R, Merkens H, Zeisler J, Lau J, Lin KS, Bénard F.   +10 more
europepmc   +1 more source

PEGASUS: Unlocking Polarity in Cell-Permeable Cyclic Peptides Using AI Models Built on Massively Parallel Biological Assays. [PDF]

J Med Chem
Baker C, Acquah FA, Chivukula LG, Wu L, Philippe-Venec L, Abedi M, Tao Y, Ramírez D, McCoy MD, Moore B, Asher JO.   +10 more
europepmc   +1 more source

Mapping the Substrate Specificity Landscape of PAD2 and PAD4 Enzymes. [PDF]

Chembiochem
Borbély A, Steckel A, Papp D, Pál D, Uray K, Gőz VG, Schlosser G.   +6 more
europepmc   +1 more source

Modulating amyloid-β 42 aggregation and neurotoxicity by Kunitz domains and their derived peptides

Rabinovich M, Lacham-Hartman S, Papo N.
europepmc   +1 more source