Results 231 to 240 of about 864,219 (301)

Celebrating Young Investigators in Peptide Science. [PDF]

J Pept Sci
Lubell WD, Wade JD, Rovero P.
europepmc   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Exploration of bioactive natural products from tropical plant genetic resources: from diversity to functional seeds. [PDF]

J Nat Med
Morita H, Hirasawa Y, Kaneda T.
europepmc   +1 more source

A decoupled alignment kernel for peptide membrane permeability predictions. [PDF]

J Cheminform
Amirahmadi A, Geylan G, De Maria L, Etminani F, Ohlsson M, Tibo A.   +5 more
europepmc   +1 more source

Stabilized thioamide peptide agonists of the neuropeptide Y type 2 receptor for targeted cancer imaging. [PDF]

RSC Chem Biol
Phan HAT, Chang Y, Barrett TM, Fiore KE, Zhang DY, Grove EJ, Petersson EJ.   +6 more
europepmc   +1 more source

Protocol for Membrane Permeability Prediction of Cyclic Peptides Using Descriptors Obtained from Extended Ensemble Molecular Dynamics Simulations and Chemical Structures. [PDF]

ACS Omega
Sugita M, Noso Y, Li J, Fujie T, Yanagisawa K, Akiyama Y.   +5 more
europepmc   +1 more source

Bioinspired peptide cyclisation enables exploration of cytochrome P450 catalysed sequential oxidation in rufomycin biosynthesis. [PDF]

Chem Sci
Peate J, Ding Y, Tomkins J, Winter HR, Zhang J, Coleman CML, Solanki P, Nicholson JH, Hopkinson T, Perez-Ortiz G, Brogan APS, McHugh TD, Jefferson RE, Barry SM.   +13 more
europepmc   +1 more source

Cyclic Peptides for Drug Development [PDF]

Angewandte Chemie - International Edition
Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives.
Christian Heinis, Alexander Lund Nielsen, Xinjian Ji   +2 more
exaly   +3 more sources

Orally Absorbed Cyclic Peptides [PDF]

Chemical Reviews, 2017
Peptides and proteins are not orally bioavailable in mammals, although a few peptides are intestinally absorbed in small amounts. Polypeptides are generally too large and polar to passively diffuse through lipid membranes, while most known active transport mechanisms facilitate cell uptake of only very small peptides. Systematic evaluations of peptides
Daniel S. Nielsen, Nicholas E. Shepherd, Weijun Xu, Andrew J. Lucke, Martin J. Stoermer, David P. Fairlie   +5 more
openaire   +4 more sources