Results 241 to 250 of about 864,219 (301)
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Journal of the American Chemical Society, 2006
The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56-63%), despite the disruption of internal amide-amide hydrogen bonding in the macrocycles.
Aucagne, Vincent +3 more
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The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56-63%), despite the disruption of internal amide-amide hydrogen bonding in the macrocycles.
Aucagne, Vincent +3 more
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International Journal of Peptide and Protein Research, 1986
In order to investigate the role of the L‐2‐hydroxy‐3‐methylbutanoic acid residue at position 2 of AM‐toxin I (cyclic tetradepsipeptide) on necrotic activity for apple leaves, two analogs, [L‐lactic acid2] AM‐toxin I and [L‐2‐hydroxy‐4‐methylpentanoic acid2] AM‐toxin I, were synthesized by the conventional method for peptide synthesis.
HISAKAZU MIHARA +6 more
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In order to investigate the role of the L‐2‐hydroxy‐3‐methylbutanoic acid residue at position 2 of AM‐toxin I (cyclic tetradepsipeptide) on necrotic activity for apple leaves, two analogs, [L‐lactic acid2] AM‐toxin I and [L‐2‐hydroxy‐4‐methylpentanoic acid2] AM‐toxin I, were synthesized by the conventional method for peptide synthesis.
HISAKAZU MIHARA +6 more
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International Journal of Peptide and Protein Research, 1985
cyclo(‐l‐Pro‐l‐Val‐l‐Pro‐l‐Val‐) (1L) and cyclo(‐l‐Pro‐d‐Val‐l‐Pro‐d‐Val‐) (1D) were synthesized by the conventional method for peptide synthesis. Conformations of 1L and 1D in solution were studied. Compound 1L has a cis‐trans‐cis‐trans backbone conformation with C2 symmetry in CDCl3.
TOMALIA DONALD A, WILSON LARRY R
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cyclo(‐l‐Pro‐l‐Val‐l‐Pro‐l‐Val‐) (1L) and cyclo(‐l‐Pro‐d‐Val‐l‐Pro‐d‐Val‐) (1D) were synthesized by the conventional method for peptide synthesis. Conformations of 1L and 1D in solution were studied. Compound 1L has a cis‐trans‐cis‐trans backbone conformation with C2 symmetry in CDCl3.
TOMALIA DONALD A, WILSON LARRY R
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Engineering Cyclic Peptide Toxins
2012Peptide-based toxins have attracted much attention in recent years for their exciting potential applications in drug design and development. This interest has arisen because toxins are highly potent and selectively target a range of physiologically important receptors.
Clark, Richard J., Craik, David J.
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Cyclic, modified and conjegated peptides
1993The subject matter for this Chapter has again been allocated sub-headings that reflect main subject areas under which a reasonable number of publications have been cited. In the absence of a detailed keyword index, the sub-headings also provide continuity from previous volumes, so that searching the...
J. S. Davies, John S. Davies
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International Journal of Peptide and Protein Research, 1981
In order to establish possible routes for the synthesis of AM‐toxins, cyclotetradepsipeptides containing Dha, Pyr‐L‐Ala‐L‐Hmb‐L‐Tyr‐NH2 were prepared and treated with TFA or anhydrous HF. The product was identified to be cyclo (‐α‐Hyala‐L‐Ala‐L‐Hmb‐L‐Tyr‐), resulting from intramolecular condensation of the α‐keto and amide group with the formation of ...
Kosaku Noda +4 more
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In order to establish possible routes for the synthesis of AM‐toxins, cyclotetradepsipeptides containing Dha, Pyr‐L‐Ala‐L‐Hmb‐L‐Tyr‐NH2 were prepared and treated with TFA or anhydrous HF. The product was identified to be cyclo (‐α‐Hyala‐L‐Ala‐L‐Hmb‐L‐Tyr‐), resulting from intramolecular condensation of the α‐keto and amide group with the formation of ...
Kosaku Noda +4 more
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International Journal of Peptide and Protein Research, 1984
In order to explore the route for cyclization of linear oligopeptide containing a ΔAla (α, β‐dehydroalanine) residue, AM‐toxin II was synthesized. As a preliminary experiment, synthesis of [L‐Phe3] AM‐toxin II, containing L‐Phe in place of L‐App (L‐2‐amino‐5‐phenylpentanoic acid), was attempted.
TOSHIRO KOZONO +4 more
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In order to explore the route for cyclization of linear oligopeptide containing a ΔAla (α, β‐dehydroalanine) residue, AM‐toxin II was synthesized. As a preliminary experiment, synthesis of [L‐Phe3] AM‐toxin II, containing L‐Phe in place of L‐App (L‐2‐amino‐5‐phenylpentanoic acid), was attempted.
TOSHIRO KOZONO +4 more
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International Journal of Peptide and Protein Research, 1980
Å number of cyclo (Δaminoacyl‐L‐aminoacyl) (Δaminoacyl =ΔAba, ΔVal, ΔLeu, ΔApp, ΔPhe and ΔTrp; L‐aminoacyl=L‐Ala, L‐Val, L‐Leu and L‐Lys (e‐Ac)) were synthesized by the condensation of cyclo (N‐acetyl‐Gly‐N‐acetyl‐L‐aminoacyl) with corresponding aldehyde or acetone and subsequent treatment with hydrazine. Each cyclo (Δaminoacyl‐L‐aminoacyl) except ones
TATSUHIKO KANMERA +3 more
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Å number of cyclo (Δaminoacyl‐L‐aminoacyl) (Δaminoacyl =ΔAba, ΔVal, ΔLeu, ΔApp, ΔPhe and ΔTrp; L‐aminoacyl=L‐Ala, L‐Val, L‐Leu and L‐Lys (e‐Ac)) were synthesized by the condensation of cyclo (N‐acetyl‐Gly‐N‐acetyl‐L‐aminoacyl) with corresponding aldehyde or acetone and subsequent treatment with hydrazine. Each cyclo (Δaminoacyl‐L‐aminoacyl) except ones
TATSUHIKO KANMERA +3 more
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Synthesis of Cyclic Peptides and Cyclic Proteins via Ligation of Peptide Hydrazides
ChemBioChem, 2012Intramolecular ligation of peptide hydrazides is reported to occur readily, causing the lactamization of fully unprotected peptides in an epimerization-free manner. This method relies on the routine procedures of Fmoc solid-phase peptide synthesis. It can be used to prepare cyclic peptides and cyclic proteins under simpler, mild conditions at lower ...
Ji-Shen, Zheng +4 more
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