Results 91 to 100 of about 2,703,759 (384)

ENERGY TRANSFER IN TRIMERIC C-PHYCOCYANIN STUDIED BY PICOSECOND FLUORESCENCE KINETICS [PDF]

, 1986
The excited state kinetics of trimeric C-phycocyanin from Mastigocladus laminosus has been measured as a function of the emission and excitation wavelength by the single-photon timing technique with picosecond resolution and simultaneous data analysis. A
Holzwarth, A. R., John, Wolfhart, Scheer, Hugo, Wendler, J.   +3 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Self-assembly antimicrobial peptide for treatment of multidrug-resistant bacterial infection

Journal of Nanobiotechnology
The wide-spreading of multidrug resistance poses a significant threat to human and animal health. Although antimicrobial peptides (AMPs) show great potential application, their instability has severely limited their clinical application.
Xuanxuan Ma, Na Yang, Ruoyu Mao, Ya Hao, Yuanyuan Li, Ying Guo, Da Teng, Yinhua Huang, Jianhua Wang   +8 more
doaj   +1 more source

A nested mixture model for protein identification using mass spectrometry

, 2010
Mass spectrometry provides a high-throughput way to identify proteins in biological samples. In a typical experiment, proteins in a sample are first broken into their constituent peptides.
Li, Qunhua, MacCoss, Michael J., Stephens, Matthew   +2 more
core   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Identification and dipeptidyl peptidase IV (DPP-IV) inhibitory activity verification of peptides from mouse lymphocytes

Food Science and Human Wellness, 2022
The objective of this study was to isolate and identify the intracellular bioactive peptides from mouse lymphocytes before and after lipopolysaccharide (LPS) stimulation, to explore novel peptides and to research the bioactive function.
Juan Wang, Yujia Xie, Yuanyuan Luan, Tingting Guo, Shanshan Xiao, Xingxing Zeng, Shaohui Zhang   +6 more
doaj   +1 more source

Peptides in Paris [PDF]

Peptide Science, 2015
The PIPS special issue features sixteen original research articles and four review articles. This issue gives a healthy slice of the science presented and inspired by the PIPS meeting as it pays homage to the pioneers, who participated at the meeting. The scientific rapport, festive environment, and educational content of this meeting in Paris inspired
Papini, Anna M. aria, Lavielle, Solange, Lubell, William D.   +2 more
openaire   +3 more sources

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

A pore-forming protein drives macropinocytosis to facilitate toad water maintaining

Communications Biology, 2022
In addition to membrane-integrated aquaporins, a novel secretory pore-forming protein, βγ-CAT, can facilitate toad water maintaining via macropinocytosis induction and exocytosis modulation, especially in responses to osmotic stress.
Zhong Zhao, Zhi-Hong Shi, Chen-Jun Ye, Yun Zhang   +3 more
doaj   +1 more source

An extra dimension in protein tagging by quantifying universal proteotypic peptides using targeted proteomics [PDF]

, 2016
The use of protein tagging to facilitate detailed characterization of target proteins has not only revolutionized cell biology, but also enabled biochemical analysis through efficient recovery of the protein complexes wherein the tagged proteins reside ...
De Sutter, Delphine, Eyckerman, Sven, Gevaert, Kris, Gonnelli, Giulia, Martens, Lennart, Samyn, Noortje, Staes, An, Timmerman, Evy, Vandemoortele, Giel, Vandermarliere, Elien   +9 more
core   +2 more sources