Results 111 to 120 of about 2,703,759 (384)

Isolation and characterisation of host defence peptides ostricacins from ostrich heterophils : a thesis presented in partial fulfilment of the requirements for the degree of Masterate of Technology in Biotechnology at Massey University, Palmerston North, New Zealand [PDF]

, 2006
Articles in Appendix 3 removed due to copyright. Articles available in print copy held in the library.Host defence peptides are ubiquitous components of innate immunity within all living organisms.
Sugiarto, Haryadi
core  

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells and diagnostic applications

Scientific Reports
Dexamethasone (DEX) is a synthetic analogue of cortisol commonly used for the treatment of different pathological conditions, comprising cancer, ocular disorders, and COVID-19 infection.
Enrico Gallo, Carlo Diaferia, Giovanni Smaldone, Elisabetta Rosa, Giovanni Pecoraro, Giancarlo Morelli, Antonella Accardo   +6 more
doaj   +1 more source

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein [PDF]

, 1991
Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is ...
Braciale, Chimini, Colbere-Garapin, Del Val, Del Val, Del Val, DeLisi, Falk, Falk, Ganem, Hans-Jürgen Schlicht, Jonjić, Junker, Keil, Margarita Del Val, Matthias J. Reddehase, Nassal, Ou, Parham, Ponta, Reddehase, Reddehase, Rothbard, Rötzschke, Rötzschke, Schlicht, Schlicht, Thomas Ruppert, Townsend, Townsend, Townsend, Townsend, Townsend, Ulrich H. Koszinowski, Van Bleek, Volkmer, Yewdell   +36 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The Small Key to the Treasure Chest: Endogenous Plant Peptides Involved in Symbiotic Interactions

Plants
Plant growth and development are inextricably connected with rhizosphere organisms. Plants have to balance between strong defenses against pathogens while modulating their immune responses to recruit beneficial organisms such as bacteria and fungi.
Anna Mamaeva, Arina Makeeva, Daria Ganaeva   +2 more
doaj   +1 more source

Structural and functional properties of food protein-derived antioxidant peptides.

Journal of food biochemistry, 2019
The aim of this work is to provide a timely examination of the structure-activity relationship of antioxidative peptides. The main production approach involves enzymatic hydrolysis of animal and plant proteins to produce protein hydrolyzates, which can ...
Ifeanyi D. Nwachukwu, R. Aluko
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

The adaptors Grb10 and Grb14 are calmodulin-binding proteins [PDF]

, 2017
We identified the Grb7 family members, Grb10 and Grb14, as Ca2+-dependent CaM-binding proteins using Ca2+-dependent CaM-affinity chromatography as we previously did with Grb7.
Angrist, Audran, Bai, Benaim, Berchtold, Blagitko, Chin, Chu, Cooney, Dagher, Daly, Daly, Depetris, Depetris, Dey, Dong, Duval, Frantz, García-Palmero, García-Palmero, García-Palmero, Giorgetti-Peraldi, Han, Han, Hansen, He, Hoeflich, Jurado, Kairouz, Kasus-Jacobi, Laemmli, Laviola, Li, Li, Liu, Lucas-Fernández, Mano, Manser, Manser, Maqani, Margolis, Margolis, Martin-Nieto, Morrione, Morrione, Nantel, O'Neil, O'Neill, Ooi, Ramos, Reilly, San José, Shen, Shen, Stein, Tanaka, Tanaka, Tanaka, Vecchione, Vetter, Villalobo, Villarroel   +61 more
core   +1 more source

In Silico Approach for Predicting Toxicity of Peptides and Proteins

PLoS ONE, 2013
Background Over the past few decades, scientific research has been focused on developing peptide/protein-based therapies to treat various diseases. With the several advantages over small molecules, including high specificity, high penetration, ease of ...
Sudheer Gupta, P. Kapoor, Kumardeep Chaudhary, A. Gautam, Rahul Kumar, G. Raghava   +5 more
semanticscholar   +1 more source