Results 101 to 110 of about 111,225 (303)

Probing the peptidoglycan molecular recognition mechanisms of innate immune receptors NOD2 and NLRP1 leucine rich repeat domains

Grimes, Catherine LeimkuhlerThe innate immune system is the body’s first line of defense against invading microbial pathogens. A critical component of this immune defense are the cytosolic NOD-like receptors (NLRs), which sense bacterial derived ...
D'Ambrosio, Elizabeth A.
core   +1 more source

Bacterial cell wall peptidoglycan synthesis.

, 2013
Schematic pathway of cell wall peptidoglycan metabolism adapted from Mengin-Lecreulx et al. [6]. Enzymes MurC, MurD and MurE are involved in de novo synthesis of the bacterial cell wall peptidoglycan.
Debanu Das (354537), Ashley M. Deacon (147523), Ian A. Wilson (113692), Dominique Mengin-Lecreulx (40108), Carol L. Farr (212414), Mireille Hervé (54410), Scott A. Lesley (147512), Heath E. Klock (147492), Marc-André Elsliger (147519), Mark W. Knuth (147499), Adam Godzik (4285), Mitchell D. Miller (147507), Hsiu-Ju Chiu (147484), Julie Feuerhelm (354539)   +13 more
core   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

Mechanism of lateral cell-wall expansion at a constant diameter in Bacillus subtilis

Nature Communications
In Escherichia coli, lateral cell-wall expansion during growth occurs by cross-linking of new glycan strands to the existing peptidoglycan network. However, it is unclear whether the same mechanism applies to other rod-shaped bacteria.
Yucheng Liang, Laure Bellard, Yung-Sing Wong, Cécile Morlot, Jean-Emmanuel Hugonnet, Filippo Rusconi, Michel Arthur   +6 more
doaj   +1 more source

Primer Preactivation of Peptidoglycan Polymerases

, 2016
Peptidoglycan glycosyltransferases are highly conserved bacterial enzymes that catalyze glycan strand polymerization to build the cell wall. Because the cell wall is essential for bacterial cell survival, these glycosyltransferases are potential ...
Yuto Sumida (1696852), Daniel E. Kahne (2193892), Tania J. Lupoli (1281309), Hirokazu Tsukamoto (1329528), Yuriy Rebets (1843078), Suzanne Walker (1281300), Yihui Wu (1707376), Tsung-Shing Andrew Wang (1281303)   +7 more
core   +1 more source

IMACulate(DE3), an E. coli Strain for High Purity His‐Tagged Protein Purifications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Immobilised Metal Affinity Chromatography (IMAC) is widely used to purify his‐tagged recombinant proteins from Escherichia coli. However, endogenous contaminants with histidine clusters, such as GFAT and PDH E1 proteins, are often co‐purified with the target protein.
Jia Q. Truong, Dingyi Yu, Nan Hao, Chris Langendorf, Keith. E. Shearwin, Jessica K. Holien   +5 more
wiley   +1 more source

Toward the characterization of peptidoglycan structure and protein-peptidoglycan interactions by solid-state NMR spectroscopy.

, 2008
peer reviewedSolid-state NMR spectroscopy is applied to intact peptidoglycan sacculi of the Gram-negative bacterium Escherichia coli. High-quality solid-state NMR spectra allow atom-resolved investigation of the peptidoglycan structure and dynamics as ...
Giustini, Cecile, Joris, Bernard, Muller, Patrick, Vollmer, Waldemar, Simorre, Jean*-Pierre, Hediger, Sabine, Bougault, Catherine, Kern, Thomas   +7 more
core   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Toxin release mediated by the novel autolysin Cwp19 in Clostridium difficile

Microbial Cell, 2018
Clostridium difficile, also known as Clostriodioides difficile, is a Gram positive, spore-forming bacterium and a leading cause of antibiotic-associated diarrhea in nosocomial environments. The key virulence factors of this pathogen are two toxins, toxin
Imane El Meouche, Johann Peltier
doaj   +1 more source

Bacterial peptidoglycan as a living polymer

Current Opinion in Chemical Biology
The peptidoglycan manifests as a multifaceted component of the bacterial cell wall. Throughout the lifecycle of the bacterium, the peptidoglycan is deconstructed, rebuilt, and remodeled for bacterial cell growth and replication. Degradation products of the peptidoglycan serve as precursors for cell-wall building blocks via recycling processes and as ...
Amr M. El-Araby, Jed F. Fisher, Shahriar Mobashery   +2 more
openaire   +2 more sources