Two New M23 Peptidoglycan Hydrolases With Distinct Net Charge [PDF]
Frontiers in Microbiology, 2021 Bacterial peptidoglycan hydrolases play an essential role in cell wall metabolism during bacterial growth, division, and elongation (autolysins) or in the elimination of closely related species from the same ecological niche (bacteriocins).
Alicja Wysocka +2 more
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One fold, many functions—M23 family of peptidoglycan hydrolases [PDF]
Frontiers in Microbiology, 2022 Bacterial cell walls are the guards of cell integrity. They are composed of peptidoglycan that provides rigidity to sustain internal turgor and ensures isolation from the external environment.
Alicja Wysocka, Izabela Sabala
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Reassessing the substrate specificities of the major Staphylococcus aureus peptidoglycan hydrolases lysostaphin and LytM [PDF]
eLifeOrchestrated action of peptidoglycan (PG) synthetases and hydrolases is vital for bacterial growth and viability. Although the function of several PG synthetases and hydrolases is well understood, the function, regulation, and mechanism of action of PG ...
Lina Antenucci +6 more
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Bacterial Cell Enlargement Requires Control of Cell Wall Stiffness Mediated by Peptidoglycan Hydrolases [PDF]
mBio, 2015 Most bacterial cells are enclosed in a single macromolecule of the cell wall polymer, peptidoglycan, which is required for shape determination and maintenance of viability, while peptidoglycan biosynthesis is an important antibiotic target.
Richard Wheeler +9 more
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The Protozoan
mBio, 2018 The human eukaryotic pathogen Trichomonas vaginalis causes trichomoniasis, a prevalent sexually transmitted infection. This extracellular protozoan is intimately associated with the human vaginal mucosa and microbiota, but key aspects of the complex ...
Jully Pinheiro +8 more
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Phenotypic and genotypic characterization of peptidoglycan hydrolases of Lactobacillus sakei [PDF]
Journal of Advanced Research, 2016 Lactobacillus sakei, a lactic acid bacterium naturally found in fresh meat and sea products, is considered to be one of the most important bacterial species involved in meat fermentation and bio-preservation. Several enzymes of Lb.
Afef Najjari +6 more
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Enhancing stability and safety of chimeric peptidoglycan hydrolases by linker engineering [PDF]
Applied Microbiology and BiotechnologySpread of antimicrobial resistance and lack of new antibiotics have brought attention to alternative strategies of combating pathogenic bacteria. One of these strategies takes advantage of the bacteriolytic activity of peptidoglycan hydrolases.
Paweł Mitkowski +6 more
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Identification of key peptidoglycan hydrolases for morphogenesis, autolysis, and peptidoglycan composition of
Microbial Cell Factories, 2012 Background Lactobacillus plantarum is commonly used in industrial fermentation processes. Selected strains are also marketed as probiotics for their health beneficial effects.
Rolain Thomas +6 more
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Reduced peptidoglycan synthesis capacity impairs growth of E. coli at high salt concentration
MBioGram-negative bacteria have a thin peptidoglycan layer between the cytoplasmic and outer membranes protecting the cell from osmotic challenges. Hydrolases of this structure are needed to cleave bonds to allow the newly synthesized peptidoglycan strands ...
VÍCTOR M Hernández-Rocamora +2 more
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Chimeric Peptidoglycan Hydrolases Kill Staphylococcal Mastitis Isolates in Raw Milk and within Bovine Mammary Gland Epithelial Cells [PDF]
Viruses, 2022 Anja P Keller +2 more
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