Results 41 to 50 of about 9,126 (180)
Peptidoglycan Hydrolase Fusions Maintain Their Parental Specificities [PDF]
Applied and Environmental Microbiology, 2006 ABSTRACT The increased incidence of bacterial antibiotic resistance has led to a renewed search for novel antimicrobials. Avoiding the use of broad-range antimicrobials through the use of specific peptidoglycan hydrolases (endolysins) might reduce the incidence of antibiotic-resistant pathogens worldwide.
David M, Donovan +5 more
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Surveying the immuno-surfacome of Staphylococcus aureus with focus on peptidoglycan hydrolases [PDF]
, 2022 Staphylococcus aureus is a major bacterial pathogen that represents a significant burden for human health, especially due to its high resistance to antibiotics. Therefore, new alternative approaches to protect patients and frail individuals against multi-
Wang, Min
core +1 more source
Toxin release mediated by the novel autolysin Cwp19 in Clostridium difficile
Microbial Cell, 2018 Clostridium difficile, also known as Clostriodioides difficile, is a Gram positive, spore-forming bacterium and a leading cause of antibiotic-associated diarrhea in nosocomial environments. The key virulence factors of this pathogen are two toxins, toxin
Imane El Meouche, Johann Peltier
doaj +1 more source
Data_Sheet_1_Two New M23 Peptidoglycan Hydrolases With Distinct Net Charge.pdf
, 2021 Bacterial peptidoglycan hydrolases play an essential role in cell wall metabolism during bacterial growth, division, and elongation (autolysins) or in the elimination of closely related species from the same ecological niche (bacteriocins).
Elżbieta Jagielska (11476111) +3 more
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Bacterial growth does require peptidoglycan hydrolases [PDF]
Molecular Microbiology, 2012 SummaryMost bacteria surround their cytoplasmic membrane with a net‐like, elastic heteropolymer, the peptidoglycan sacculus, to protect themselves from bursting due to the turgor and to maintain cell shape. It has been assumed that growing bacteria require peptidoglycan hydrolases to open meshes in the peptidoglycan net allowing the insertion of the ...
openaire +4 more sources
Zymogram Assay for the Detection of Peptidoglycan Hydrolases in Streptococcus mutans
Bio-Protocol, 2013 Peptidoglycan hydrolases or autolysins are enzymes capable of cleaving covalent bonds in bacterial peptidoglycan cell wall layer. They can participate in the cell division process, in the release of turnover products from peptidoglycan during cell growth,
Delphine Dufour, Céline Lévesque
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Biochemical Studies of Peptidoglycan Hydrolases from Commensal and Pathogenic Bacteria
, 2021 The intestinal microbiota consists of diverse bacterial species and their effectors that play key roles in regulating human health. Interestingly, cell wall, or peptidoglycan, fragments from commensal and pathogenic bacteria can activate host immunity ...
Espinosa, Juliel
core +1 more source
Scientific Reports, 2022 Endolysins are bacteriophage-encoded peptidoglycan-degrading enzymes with potential applications for treatment of multidrug-resistant bacterial infections. Hafnia phage Enc34 encodes an unusual endolysin with an N-terminal enzymatically active domain and
Elina Cernooka +4 more
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Carbohydrate recognition and lysis by bacterial peptidoglycan hydrolases
Current Opinion in Structural Biology, 2017 The major component of bacterial cell wall is peptidoglycan (PG), a complex polymer formed by long glycan chains cross-linked by peptide stems. PG is in constant equilibrium requiring well-orchestrated coordination between synthesis and degradation. The resulting cell-wall fragments can be recycled, act as messengers for bacterial communication, as ...
Alcorlo, Martín +3 more
openaire +3 more sources
BMC Genomics, 2005 Background The metabolism of bacterial peptidoglycan is a dynamic process, synthases and cleavage enzymes are functionally coordinated. Lytic Transglycosylase enzymes (LT) are part of multienzyme complexes which regulate bacterial division and elongation.
Di Guilmi Anne +3 more
doaj +1 more source