Proteomics Used in Identifying Novel Correlates of Disease in Pediatric Metabolic Dysfunction‐Associated Steatotic Liver Disease [PDF]
Clinical and Translational ScienceMetabolic dysfunction‐associated liver disease (MASLD) is a leading cause of liver disease in children. There is a paucity of data on potential biomarkers and therapeutic targets, especially in pediatric MASLD.
Diego Paine‐Cabrera +6 more
doaj +4 more sources
The impact of CwlM depletion on the susceptibility of Mycobacterium smegmatis to anti-tuberculosis drugs. [PDF]
PLoS ONECwlM, identified as an N-acetylmuramoyl-l-alanine amidase, plays crucial roles in the synthesis and remodeling of peptidoglycan in mycobacteria. This protein also appears to participate in both drug susceptibility and tolerance mechanisms within these ...
Shufeng Yang +5 more
doaj +3 more sources
Characterization of the major autolysin (AtlC) of Staphylococcus carnosus [PDF]
BMC MicrobiologyBackground Autolysis by cellular peptidoglycan hydrolases (PGH) is a well-known phenomenon in bacteria. During food fermentation, autolysis of starter cultures can exert an accelerating effect, as described in many studies on cheese ripening. In contrast,
Maximilian Merz +3 more
doaj +3 more sources
Structure, Function, and Regulation of LytA: The N-Acetylmuramoyl-l-alanine Amidase Driving the “Suicidal Tendencies” of Streptococcus pneumoniae—A Review [PDF]
MicroorganismsStreptococcus pneumoniae (pneumococcus) is a significant human pathogen responsible for a range of diseases from mild infections to invasive pneumococcal diseases, particularly affecting children, the elderly, and immunocompromised individuals.
Ernesto García
doaj +4 more sources
A Clostridioides difficile endolysin modulates toxin secretion without cell lysis [PDF]
Communications BiologyThe Clostridia produce and secrete Large Clostridial Glucosylating Toxins (LCGTs) responsible for disease symptoms, but the secretion mechanism is largely unknown. Recently, a holin-like protein was shown to be essential for toxin secretion.
Milena M. Awad +8 more
doaj +3 more sources
Genomic Analysis of 48 Paenibacillus larvae Bacteriophages [PDF]
Viruses, 2018 The antibiotic-resistant bacterium Paenibacillus larvae is the causative agent of American foulbrood (AFB), currently the most destructive bacterial disease in honeybees. Phages that infect P. larvae were isolated as early as the 1950s, but it is only in
Casey Stamereilers +7 more
doaj +3 more sources
Scientific Reports, 2023 Multidrug-resistant (MDR) bacteria have become a growing threat to public health. The gram-positive Enterococcus faecium is classified by WHO as a high-priority pathogen among the global priority list of antibiotic-resistant bacteria.
Georgios E. Premetis +3 more
doaj +2 more sources
Expression of a Clostridium perfringens genome-encoded putative N-acetylmuramoyl-L-alanine amidase as a potential antimicrobial to control the bacterium. [PDF]
Arch Microbiol, 2013 Clostridium perfringens is a gram-positive, spore-forming anaerobic bacterium that plays a substantial role in non-foodborne human, animal, and avian diseases as well as human foodborne disease. Previously discovered C. perfringens bacteriophage lytic enzyme amino acid sequences were utilized to identify putative prophage lysins or autolysins by BLAST ...
Tillman GE +3 more
europepmc +4 more sources
PL3 Amidase, a Tailor-made Lysin Constructed by Domain Shuffling
Frontiers in Microbiology, 2016 The emergence and spread of antibiotic-resistant bacteria is pushing the need of alternative treatments. In this context, phage therapy is already a reality to successfully fight certain multiresistant bacteria.
Blas Blázquez +4 more
doaj +2 more sources
mBio, 2014 The cytosolic N-acetylmuramoyl-l-alanine amidase LytA protein of Streptococcus pneumoniae, which is released by bacterial lysis, associates with the cell wall via its choline-binding motif.
Peter Mellroth +10 more
doaj +2 more sources