Encapsulation of the septal cell wall protects Streptococcus pneumoniae from its major peptidoglycan hydrolase and host defenses. [PDF]
PLoS Pathogens, 2022 Synthesis of the capsular polysaccharide, a major virulence factor for many pathogenic bacteria, is required for bacterial survival within the infected host.
Joana Figueiredo +10 more
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Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in
mBio, 2019 Streptococcus pneumoniae is a leading killer of infants and immunocompromised adults and has become increasingly resistant to major antibiotics. Therefore, the development of new antibiotic strategies is desperately needed.
Britta E. Rued +11 more
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A new regulator of the Staphylococcus aureus peptidoglycan hydrolase Sle1. [PDF]
PLoS GeneticsRegulation of peptidoglycan hydrolases is crucial for bacterial cell integrity, growth and division. In the bacterial pathogen Staphylococcus aureus, the amidase Sle1 is a key autolysin required for septum splitting and daughter cell separation.
Helena Veiga +3 more
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Inhibiting Peptidoglycan Hydrolase Alleviates MRSA Pneumonia Through Autolysin-Mediated MDP-NOD2 Pathway [PDF]
Infection and Drug ResistanceYang Yang,1,2 Zongze Yao,1 Jiazhen Zhang,1 Wei Shao,3 Bo Li,2 Huihui Wu,2 Wenjian Tang,3 Jing Zhang2 1School of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 2Anhui Province Key Laboratory of Occupational ...
Yang Y +7 more
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Secreted antigen A peptidoglycan hydrolase is essential for Enterococcus faecium cell separation and priming of immune checkpoint inhibitor therapy [PDF]
eLifeEnterococcus faecium is a microbiota species in humans that can modulate host immunity (Griffin and Hang, 2022), but has also acquired antibiotic resistance and is a major cause of hospital-associated infections (Van Tyne and Gilmore, 2014).
Steven Klupt +8 more
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Identification of the chain-dispersing peptidoglycan hydrolase LytB of Streptococcus gordonii. [PDF]
PLoS ONE, 2017 Bacterial cell division ends with the separation of the daughter cells, a process that requires peptidoglycan hydrolases (PGHs). Bacteria lacking cell separating PGHs are impaired in cell separation with the formation of long chains or clusters.
Riccardo Arrigucci, Gianni Pozzi
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Multilevel Regulation of Peptidoglycan Dynamics in Bacteria: From Molecular Mechanisms to Applied Perspectives [PDF]
BiomoleculesPeptidoglycan, a crucial constituent of the bacterial cell envelope, is essential for maintaining cellular integrity and morphology. Elucidating the regulatory processes that coordinate its biosynthesis and turnover not only addresses a fundamental ...
Chang Dong +4 more
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LytF contributes to pilus extrusion during natural competence in Streptococcus sanguinis SK36 [PDF]
Journal of BacteriologyStreptococci may enter a physiological state called competence, during which they express a specific set of genes required for exogenous DNA uptake and its subsequent integration into the genome through homologous recombination.
Rebekka Moe +4 more
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Genetic Dissection of the Type VI Secretion System in
mBio, 2016 The type VI secretion system (T6SS) is a widespread secretory apparatus produced by Gram-negative bacteria that has emerged as a potent mediator of antibacterial activity during interbacterial interactions.
Brent S. Weber +8 more
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eLife, 2022 The helical shape of Helicobacter pylori cells promotes robust stomach colonization; however, how the helical shape of H. pylori cells is determined is unresolved.
Sophie R Sichel +2 more
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