Identification of the chain-dispersing peptidoglycan hydrolase LytB of Streptococcus gordonii. [PDF]
PLoS ONE, 2017 Bacterial cell division ends with the separation of the daughter cells, a process that requires peptidoglycan hydrolases (PGHs). Bacteria lacking cell separating PGHs are impaired in cell separation with the formation of long chains or clusters.
Riccardo Arrigucci, Gianni Pozzi
doaj +9 more sources
The hydrolase LpqI primes mycobacterial peptidoglycan recycling [PDF]
Nature Communications, 2019 Bacterial growth and division require remodelling of the cell wall, which generates free peptidoglycan fragments. Here, Moynihan et al. show that Mycobacterium tuberculosis can recycle components of their peptidoglycan, and characterise a crucial enzyme ...
Patrick J. Moynihan +7 more
doaj +8 more sources
Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in
mBio, 2019 Streptococcus pneumoniae is a leading killer of infants and immunocompromised adults and has become increasingly resistant to major antibiotics. Therefore, the development of new antibiotic strategies is desperately needed.
Britta E. Rued +11 more
doaj +4 more sources
A new regulator of the Staphylococcus aureus peptidoglycan hydrolase Sle1. [PDF]
PLoS GeneticsRegulation of peptidoglycan hydrolases is crucial for bacterial cell integrity, growth and division. In the bacterial pathogen Staphylococcus aureus, the amidase Sle1 is a key autolysin required for septum splitting and daughter cell separation.
Helena Veiga +3 more
doaj +4 more sources
Various checkpoints prevent the synthesis ofStaphylococcus aureuspeptidoglycan hydrolase LytM in the stationary growth phase [PDF]
RNA Biology, 2016 In Staphylococcus aureus, peptidoglycan metabolism plays a role in the host inflammatory response and pathogenesis. Transcription of the peptidoglycan hydrolases is activated by the essential two-component system WalKR at low cell density.
Efthimia Lioliou +2 more
exaly +5 more sources
Peptidoglycan Hydrolase Fusions Maintain Their Parental Specificities [PDF]
Applied and Environmental Microbiology, 2006 ABSTRACT The increased incidence of bacterial antibiotic resistance has led to a renewed search for novel antimicrobials. Avoiding the use of broad-range antimicrobials through the use of specific peptidoglycan hydrolases (endolysins) might reduce the incidence of antibiotic-resistant pathogens worldwide.
David M, Donovan +5 more
openaire +3 more sources
Protein complexes and proteolytic activation of the cell wall hydrolase RipA regulate septal resolution in mycobacteria. [PDF]
PLoS Pathogens, 2013 Peptidoglycan hydrolases are a double-edged sword. They are required for normal cell division, but when dysregulated can become autolysins lethal to bacteria.
Michael C Chao +7 more
doaj +3 more sources
Encapsulation of the septal cell wall protects Streptococcus pneumoniae from its major peptidoglycan hydrolase and host defenses. [PDF]
PLoS Pathogens, 2022 Synthesis of the capsular polysaccharide, a major virulence factor for many pathogenic bacteria, is required for bacterial survival within the infected host.
Joana Figueiredo +10 more
doaj +2 more sources
Identification of key peptidoglycan hydrolases for morphogenesis, autolysis, and peptidoglycan composition of
Microbial Cell Factories, 2012 Background Lactobacillus plantarum is commonly used in industrial fermentation processes. Selected strains are also marketed as probiotics for their health beneficial effects.
Rolain Thomas +6 more
doaj +6 more sources
Inhibiting Peptidoglycan Hydrolase Alleviates MRSA Pneumonia Through Autolysin-Mediated MDP-NOD2 Pathway [PDF]
Infection and Drug ResistanceYang Yang,1,2 Zongze Yao,1 Jiazhen Zhang,1 Wei Shao,3 Bo Li,2 Huihui Wu,2 Wenjian Tang,3 Jing Zhang2 1School of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 2Anhui Province Key Laboratory of Occupational ...
Yang Y +7 more
doaj +2 more sources