Genetic Dissection of the Type VI Secretion System in
mBio, 2016 The type VI secretion system (T6SS) is a widespread secretory apparatus produced by Gram-negative bacteria that has emerged as a potent mediator of antibacterial activity during interbacterial interactions.
Brent S. Weber +8 more
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Protein complexes and proteolytic activation of the cell wall hydrolase RipA regulate septal resolution in mycobacteria. [PDF]
PLoS Pathogens, 2013 Peptidoglycan hydrolases are a double-edged sword. They are required for normal cell division, but when dysregulated can become autolysins lethal to bacteria.
Michael C Chao +7 more
doaj +11 more sources
Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in
mBio, 2019 Streptococcus pneumoniae is a leading killer of infants and immunocompromised adults and has become increasingly resistant to major antibiotics. Therefore, the development of new antibiotic strategies is desperately needed.
Britta E. Rued +11 more
doaj +2 more sources
Encapsulation of the septal cell wall protects Streptococcus pneumoniae from its major peptidoglycan hydrolase and host defenses. [PDF]
PLoS Pathogens, 2022 Synthesis of the capsular polysaccharide, a major virulence factor for many pathogenic bacteria, is required for bacterial survival within the infected host.
Joana Figueiredo +10 more
doaj +2 more sources
Structure and activity of ChiX: a peptidoglycan hydrolase required for chitinase secretion by <i>Serratia marcescens</i>. [PDF]
Biochem J, 2018 The Gram‐negative bacterium Serratia marcescens secretes a number of proteins that are involved in extracellular chitin degradation. This so‐called chitinolytic machinery includes three types of chitinase enzymes and a lytic polysaccharide monooxygenase.
Owen RA +6 more
europepmc +4 more sources
A new regulator of the Staphylococcus aureus peptidoglycan hydrolase Sle1. [PDF]
PLoS GeneticsRegulation of peptidoglycan hydrolases is crucial for bacterial cell integrity, growth and division. In the bacterial pathogen Staphylococcus aureus, the amidase Sle1 is a key autolysin required for septum splitting and daughter cell separation.
Helena Veiga +3 more
doaj +2 more sources
Inhibiting Peptidoglycan Hydrolase Alleviates MRSA Pneumonia Through Autolysin-Mediated MDP-NOD2 Pathway [PDF]
Infection and Drug ResistanceYang Yang,1,2 Zongze Yao,1 Jiazhen Zhang,1 Wei Shao,3 Bo Li,2 Huihui Wu,2 Wenjian Tang,3 Jing Zhang2 1School of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 2Anhui Province Key Laboratory of Occupational ...
Yang Y +7 more
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Secreted antigen A peptidoglycan hydrolase is essential for Enterococcus faecium cell separation and priming of immune checkpoint inhibitor therapy [PDF]
eLifeEnterococcus faecium is a microbiota species in humans that can modulate host immunity (Griffin and Hang, 2022), but has also acquired antibiotic resistance and is a major cause of hospital-associated infections (Van Tyne and Gilmore, 2014).
Steven Klupt +8 more
doaj +2 more sources
Identification of the chain-dispersing peptidoglycan hydrolase LytB of Streptococcus gordonii. [PDF]
PLoS ONE, 2017 Bacterial cell division ends with the separation of the daughter cells, a process that requires peptidoglycan hydrolases (PGHs). Bacteria lacking cell separating PGHs are impaired in cell separation with the formation of long chains or clusters.
Riccardo Arrigucci, Gianni Pozzi
doaj +2 more sources
Enterococcus faecium sagA mutants have cell envelope defects influencing antibiotic resistance and bacteriophage susceptibility [PDF]
Journal of BacteriologyEnterococcus faecium is a gram-positive bacterium that is resident to the intestines of animals including humans. E. faecium is also an opportunistic pathogen that causes multidrug-resistant (MDR) infections. Bacteriophages (phages) have been proposed as
Garima Arya +5 more
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