Results 21 to 30 of about 12,407 (196)
eLife, 2022 The helical shape of Helicobacter pylori cells promotes robust stomach colonization; however, how the helical shape of H. pylori cells is determined is unresolved.
Sophie R Sichel +2 more
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mBio, 2023 Most bacterial cell envelopes contain a cell wall layer made of peptidoglycan. The synthesis of new peptidoglycan is critical for cell growth, division, and morphogenesis and is also coordinated with peptidoglycan hydrolysis to accommodate the new ...
Michelle Wang +2 more
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Bacterial peptidoglycan (murein) hydrolases [PDF]
FEMS Microbiology Reviews, 2008 Most bacteria have multiple peptidoglycan hydrolases capable of cleaving covalent bonds in peptidoglycan sacculi or its fragments. An overview of the different classes of peptidoglycan hydrolases and their cleavage sites is provided. The physiological functions of these enzymes include the regulation of cell wall growth, the turnover of peptidoglycan ...
Vollmer W, Joris B, Charlier P, Foster S
openaire +5 more sources
Structure-based inhibitor design for reshaping bacterial morphology
Communications Biology, 2022 Peptidoglycan hydrolase 3 (Pgp3) inhibitors are designed that can change the helical morphology of Campylobacter jejuni to rod-shaped and decrease its virulence.
Yuri Choi +13 more
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Characterisation of the peptidoglycan hydrolases of Listeria monocytogenes EGD [PDF]
FEMS Microbiology Letters, 2006 The peptidoglycan hydrolase profile of Listeria monocytogenes EGD has been characterised under a variety of environmental and physiological conditions, using renaturing sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The profiles show activities ranging from 29 to 186 kDa.
A M, McLaughlan, S J, Foster
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Frontiers in Microbiology, 2021 Peptidoglycan (PG) hydrolases play important roles in various aspects of bacterial physiology, including cytokinesis, PG synthesis, quality control of PG, PG recycling, and antibiotic resistance. However, the regulatory mechanisms of their expression are
Yung Jae Kim +7 more
doaj +1 more source
A holin/peptidoglycan hydrolase‐dependent protein secretion system [PDF]
Molecular Microbiology, 2020 AbstractGram‐negative bacteria have evolved numerous pathways to secrete proteins across their complex cell envelopes. Here, we describe a protein secretion system that uses a holin membrane protein in tandem with a cell wall‐editing enzyme to mediate the secretion of substrate proteins from the periplasm to the cell exterior.
Tracy Palmer +4 more
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Cell splitting in Staphylococcus aureus is controlled by an adaptor protein facilitating degradation of a peptidoglycan hydrolase. [PDF]
PLoS GenetRegulated protein degradation by Clp proteases is a highly conserved post-translational control mechanism in bacteria. In Staphylococcus aureus, the ClpXP complex targets the peptidoglycan hydrolase Sle1, maintaining a tightly regulated balance between ...
Barbuti MD +7 more
europepmc +2 more sources
Regulated proteolysis of a cross-link-specific peptidoglycan hydrolase contributes to bacterial morphogenesis. [PDF]
Proc Natl Acad Sci U S A, 2015 Bacterial growth and morphogenesis are intimately coupled to expansion of peptidoglycan (PG), an extensively cross-linked macromolecule that forms a protective mesh-like sacculus around the cytoplasmic membrane.
Singh SK, Parveen S, SaiSree L, Reddy M.
europepmc +2 more sources
, 2021 Bacteria are surrounded by a peptidoglycan cell wall that is essential for their survival1. During cell wall assembly, a lipid-linked disaccharide-peptide precursor called Lipid II is polymerized and crosslinked to produce mature peptidoglycan.
Kahne, Daniel +5 more
core +1 more source