Results 21 to 30 of about 11,952 (167)

Asymmetric peptidoglycan editing generates cell curvature in Bdellovibrio predatory bacteria

Nature Communications, 2022
Cells of the predatory bacterium Bdellovibrio bacteriovorus, which invades and replicates within the periplasm of other bacteria, have a characteristic curved rod shape. Here, Banks et al.
Emma J. Banks, Mauricio Valdivia-Delgado, Jacob Biboy, Amber Wilson, Ian T. Cadby, Waldemar Vollmer, Carey Lambert, Andrew L. Lovering, R. Elizabeth Sockett   +8 more
doaj   +1 more source

Peptidoglycan Hydrolase Fusions Maintain Their Parental Specificities [PDF]

Applied and Environmental Microbiology, 2006
ABSTRACT The increased incidence of bacterial antibiotic resistance has led to a renewed search for novel antimicrobials. Avoiding the use of broad-range antimicrobials through the use of specific peptidoglycan hydrolases (endolysins) might reduce the incidence of antibiotic-resistant pathogens worldwide.
David M, Donovan, Shengli, Dong, Wes, Garrett, Geneviève M, Rousseau, Sylvain, Moineau, David G, Pritchard   +5 more
openaire   +2 more sources

Genetic Evidence for Distinct Functions of Peptidoglycan Endopeptidases in Escherichia coli

Frontiers in Microbiology, 2020
Peptidoglycan (PG) is an essential component of the bacterial exoskeleton that plays a pivotal role in the maintenance of cell shape and resistance to cell lysis under high turgor pressures.
Si Hyoung Park, Yung Jae Kim, Han Byeol Lee, Yeong-Jae Seok, Chang-Ro Lee   +4 more
doaj   +1 more source

Peptidoglycan Hydrolases of Escherichia coli [PDF]

Microbiology and Molecular Biology Reviews, 2011
SUMMARYThe review summarizes the abundant information on the 35 identified peptidoglycan (PG) hydrolases ofEscherichia coliclassified into 12 distinct families, including mainly glycosidases, peptidases, and amidases. An attempt is also made to critically assess their functions in PG maturation, turnover, elongation, septation, and recycling as well as
openaire   +2 more sources

Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis

eLife, 2019
We discovered that Enterococcus faecium (E. faecium), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism ...
Byungchul Kim, Yen-Chih Wang, Charles W Hespen, Juliel Espinosa, Jeanne Salje, Kavita J Rangan, Deena A Oren, Jin Young Kang, Virginia A Pedicord, Howard C Hang   +9 more
doaj   +1 more source

Divergent Effects of Peptidoglycan Carboxypeptidase DacA on Intrinsic β-Lactam and Vancomycin Resistance

Microbiology Spectrum, 2022
Vancomycin and β-lactams are clinically important antibiotics that inhibit the formation of peptidoglycan cross-links, but their binding targets are different.
Si Hyoung Park, Umji Choi, Su-Hyun Ryu, Han Byeol Lee, Jin-Won Lee, Chang-Ro Lee   +5 more
doaj   +1 more source

A second endolysin gene is fully embedded in-frame with the lysA gene of mycobacteriophage Ms6. [PDF]

PLoS ONE, 2011
Mycobacteriophages are dsDNA viruses that infect mycobacterial hosts. The mycobacteriophage Ms6 accomplishes lysis by producing two cell wall hydrolytic enzymes, Lysin A (LysA) that possesses a central peptidoglycan recognition protein (PGRP) super ...
Maria João Catalão, Catarina Milho, Filipa Gil, José Moniz-Pereira, Madalena Pimentel   +4 more
doaj   +1 more source

The Molecular Basis for Escherichia coli O157:H7 Phage FAHEc1 Endolysin Function and Protein Engineering to Increase Thermal Stability

Viruses, 2021
Bacteriophage-encoded endolysins have been identified as antibacterial candidates. However, the development of endolysins as mainstream antibacterial agents first requires a comprehensive biochemical understanding. This study defines the atomic structure
Michael J. Love, David Coombes, Sarah H. Manners, Gayan S. Abeysekera, Craig Billington, Renwick C. J. Dobson   +5 more
doaj   +1 more source

Two-step localization driven by peptidoglycan hydrolase in interbacterial predation. [PDF]

ISME J
Abstract Mechanisms of bacterial predation are crucial for revealing microbial adaptation strategies and interaction behaviors in the environment, yet they remain poorly understood. Previously, predators were reported to localize prey via specific cues.
Song H, Zhu Y, Qu Z, Zhu M, Li X, Zhao L, Wang K, Zhang R, Cui L, Li Y, Bian Z, Zhang W, Chen Y, Du L, Wang JL, Zhao X, Deng L, Wang Y.   +17 more
europepmc   +4 more sources

Bacterial growth does require peptidoglycan hydrolases [PDF]

Molecular Microbiology, 2012
SummaryMost bacteria surround their cytoplasmic membrane with a net‐like, elastic heteropolymer, the peptidoglycan sacculus, to protect themselves from bursting due to the turgor and to maintain cell shape. It has been assumed that growing bacteria require peptidoglycan hydrolases to open meshes in the peptidoglycan net allowing the insertion of the ...
openaire   +4 more sources