Results 21 to 30 of about 20,249 (205)
Frontiers in Microbiology, 2021 Peptidoglycan (PG) hydrolases play important roles in various aspects of bacterial physiology, including cytokinesis, PG synthesis, quality control of PG, PG recycling, and antibiotic resistance. However, the regulatory mechanisms of their expression are
Yung Jae Kim +7 more
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Asymmetric peptidoglycan editing generates cell curvature in Bdellovibrio predatory bacteria
Nature Communications, 2022 Cells of the predatory bacterium Bdellovibrio bacteriovorus, which invades and replicates within the periplasm of other bacteria, have a characteristic curved rod shape. Here, Banks et al.
Emma J. Banks +8 more
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Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus [PDF]
Applied Microbiology and Biotechnology, 2012 Bacteria of the genus Staphylococcus are common pathogens responsible for a broad spectrum of human and animal infections and belong to the most important etiological factors causing food poisoning. Because of rapid increase in the prevalence of isolation of staphylococci resistant to many antibiotics, there is an urgent need for the development of new
Szweda, Piotr +5 more
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Peptidoglycan Hydrolase Fusions Maintain Their Parental Specificities [PDF]
Applied and Environmental Microbiology, 2006 ABSTRACT The increased incidence of bacterial antibiotic resistance has led to a renewed search for novel antimicrobials. Avoiding the use of broad-range antimicrobials through the use of specific peptidoglycan hydrolases (endolysins) might reduce the incidence of antibiotic-resistant pathogens worldwide.
David M, Donovan +5 more
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Genetic Evidence for Distinct Functions of Peptidoglycan Endopeptidases in Escherichia coli
Frontiers in Microbiology, 2020 Peptidoglycan (PG) is an essential component of the bacterial exoskeleton that plays a pivotal role in the maintenance of cell shape and resistance to cell lysis under high turgor pressures.
Si Hyoung Park +4 more
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Microbiology Spectrum, 2022 Vancomycin and β-lactams are clinically important antibiotics that inhibit the formation of peptidoglycan cross-links, but their binding targets are different.
Si Hyoung Park +5 more
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A new peptidoglycan hydrolase in Streptococcus pneumoniae [PDF]
FEMS Microbiology Letters, 1986 The use of a mutant of Streptococcus pneumoniae deleted in the lytA gene coding for the N-acetyl-muramyl-l-alanine amidase, and therefore devoid of any amidase, has allowed the identification of a new murein hydrolase activity in this bacterium. This enzyme (or enzymes) acted as an autolysin when the cultures were grown at 30°C.
J.M. SaÅchez-Puelles +5 more
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eLife, 2019 We discovered that Enterococcus faecium (E. faecium), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism ...
Byungchul Kim +9 more
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A second endolysin gene is fully embedded in-frame with the lysA gene of mycobacteriophage Ms6. [PDF]
PLoS ONE, 2011 Mycobacteriophages are dsDNA viruses that infect mycobacterial hosts. The mycobacteriophage Ms6 accomplishes lysis by producing two cell wall hydrolytic enzymes, Lysin A (LysA) that possesses a central peptidoglycan recognition protein (PGRP) super ...
Maria João Catalão +4 more
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Two Pfam protein families characterized by a crystal structure of protein lpg2210 from Legionella pneumophila. [PDF]
, 2013 BackgroundEvery genome contains a large number of uncharacterized proteins that may encode entirely novel biological systems. Many of these uncharacterized proteins fall into related sequence families. By applying sequence and structural analysis we hope
Aravind, L +11 more
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