Results 41 to 50 of about 12,407 (196)
Bacterial growth does require peptidoglycan hydrolases [PDF]
Molecular Microbiology, 2012 SummaryMost bacteria surround their cytoplasmic membrane with a net‐like, elastic heteropolymer, the peptidoglycan sacculus, to protect themselves from bursting due to the turgor and to maintain cell shape. It has been assumed that growing bacteria require peptidoglycan hydrolases to open meshes in the peptidoglycan net allowing the insertion of the ...
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Biochemical Studies of Peptidoglycan Hydrolases from Commensal and Pathogenic Bacteria
, 2021 The intestinal microbiota consists of diverse bacterial species and their effectors that play key roles in regulating human health. Interestingly, cell wall, or peptidoglycan, fragments from commensal and pathogenic bacteria can activate host immunity ...
Espinosa, Juliel
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In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA). [PDF]
PLoS Pathogens, 2017 The O-acetylation of the essential cell wall polymer peptidoglycan occurs in most Gram-positive bacterial pathogens, including species of Staphylococcus, Streptococcus and Enterococcus. This modification to peptidoglycan protects these pathogens from the
David Sychantha +9 more
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PhiA, a Peptidoglycan Hydrolase Inhibitor of Brucella Involved in the Virulence Process. [PDF]
Infect Immun, 2019 The peptidoglycan in Gram-negative bacteria is a dynamic structure in constant remodeling. This dynamism, achieved through synthesis and degradation, is essential because the peptidoglycan is necessary to maintain the structure of the cell but has to have enough plasticity to allow the transport and assembly of macromolecular complexes in the periplasm
Del Giudice MG +3 more
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A conditional nature for the synthetical lethality between defects in lipid and peptidoglycan biosynthesis [PDF]
, 2023 [Extract] We write to provide an alternative view on the synthetic lethality between lipid and peptidoglycan synthesis (fabH and nlpI) reported in a recent PNAS article, “Cross-talk between phospholipid synthesis and peptidoglycan expansion by a cell ...
Totsika, Makrina +2 more
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A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens. [PDF]
Science, 2016 The intestinal microbiome modulates host susceptibility to enteric pathogens, but the specific protective factors and mechanisms of individual bacterial species are not fully characterized. We show that secreted antigen A (SagA) from Enterococcus faecium is sufficient to protect Caenorhabditis elegans
Rangan KJ +7 more
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Carbohydrate recognition and lysis by bacterial peptidoglycan hydrolases
Current Opinion in Structural Biology, 2017 The major component of bacterial cell wall is peptidoglycan (PG), a complex polymer formed by long glycan chains cross-linked by peptide stems. PG is in constant equilibrium requiring well-orchestrated coordination between synthesis and degradation. The resulting cell-wall fragments can be recycled, act as messengers for bacterial communication, as ...
Alcorlo, Martín +3 more
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Prediction of peptidoglycan hydrolases- a new class of antibacterial proteins [PDF]
BMC Genomics, 2016 The efficacy of antibiotics against bacterial infections is decreasing due to the development of resistance in bacteria, and thus, there is a need to search for potential alternatives to antibiotics. In this scenario, peptidoglycan hydrolases can be used as alternate antibacterial agents due to their unique property of cleaving peptidoglycan cell wall ...
Sharma, Ashok K. +4 more
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Microbiology Spectrum, 2023 Peptidoglycan (PG) is an essential bacterial architecture pivotal for shape maintenance and adaptation to osmotic stress. Although PG synthesis and modification are tightly regulated under harsh environmental stresses, few related mechanisms have been ...
Umji Choi +4 more
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Two New M23 Peptidoglycan Hydrolases With Distinct Net Charge [PDF]
Frontiers in Microbiology, 2021 Bacterial peptidoglycan hydrolases play an essential role in cell wall metabolism during bacterial growth, division, and elongation (autolysins) or in the elimination of closely related species from the same ecological niche (bacteriocins). Most studies concerning the peptidoglycan hydrolases present in Gram-positive bacteria have focused on clinically
Alicja Wysocka +3 more
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