Deficiency of RgpG causes major defects in cell division and biofilm formation, and deficiency of LytR-CpsAPsr family proteins leads to accumulation of cell wall antigens in culture medium by Streptococcus mutans [PDF]
, 2017 Streptococcus mutans is known to possess rhamnose-glucose polysaccharide (RGP), a major cell wall antigen. S. mutans strains deficient in rgpG , encoding the first enzyme of the RGP biosynthesis
Beatty, Wandy L +6 more
core +2 more sources
Quantitative Proteomic Analysis Reveals Changes in the Benchmark Corynebacterium pseudotuberculosis Biovar Equi Exoproteome after Passage in a Murine Host [PDF]
, 2017 Corynebacterium pseudotuberculosis biovar equi is the etiologic agent of ulcerative lymphangitis. To investigate proteins that could be related to the virulence of this pathogen, we combined an experimental passage process using a murine model and high ...
Adriano M. C. Pimenta +12 more
core +4 more sources
More than just lysins: peptidoglycan hydrolases tailor the cell wall [PDF]
Current Opinion in Microbiology, 2011 Enzymes that degrade the peptidoglycan (PG) cell wall layer called PG hydrolases or autolysins are often thought of as destructive forces. Phages employ them to lyse their host for the release of virion particles and some bacteria secrete them to eliminate (lyse) their competition.
Tsuyoshi, Uehara, Thomas G, Bernhardt
openaire +2 more sources
Journal of BacteriologyThe peptidoglycan (PG) cell wall is a mesh-like layer that shapes bacteria and protects against osmotically induced lysis. PG is composed of glycan strands and peptide chains that link together to form a continuous layer that surrounds the cell.
Joseph C. Bryant +5 more
doaj +1 more source
Advanced Science, EarlyView.Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li +12 more
wiley +1 more source
In Silico Assigned Resistance Genes Confer Bifidobacterium with Partial Resistance to Aminoglycosides but Not to Β-Lactams [PDF]
, 2013 peer-reviewedBifidobacteria have received significant attention due to their contribution to human gut health and the use of specific strains as probiotics.
Cotter, Paul D. +6 more
core +8 more sources
Structural basis of the novel S. pneumoniae virulence factor, GHIP, a glycosyl hydrolase 25 participating in host-cell invasion. [PDF]
PLoS ONE, 2013 Pathogenic bacteria produce a wide variety of virulence factors that are considered to be potential antibiotic targets. In this study, we report the crystal structure of a novel S.
Siqiang Niu +15 more
doaj +1 more source
' Lactobacillus fermentum ' 3872 genome sequencing reveals plasmid and chromosomal genes potentially involved in a probiotic activity. [PDF]
, 2015 In this report we describe a ' Lactobacillus fermentum ' 3872 plasmid (pLF3872) not previously found in any other strain of this species. The analysis of the complete sequence of this plasmid revealed the presence of a gene encoding a large collagen ...
A. M. Seddon +33 more
core +1 more source
Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS
Advanced Science, EarlyView.ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi +4 more
wiley +1 more source
Biotechnology for Biofuels and Bioproducts, 2023 Background Traditional bioethanol fermentation industries are not operated under strict sterile conditions and are prone to microbial contamination.
Maulik H. Patel +3 more
doaj +1 more source