Results 81 to 90 of about 11,952 (167)

Fungicide Drives De Novo Evolution of Multidrug Resistance in the Plant Growth Promoting Rhizobacterium, Pseudomonas fluorescens

Evolutionary Applications, Volume 19, Issue 8, August 2026.
ABSTRACT Soil microbial communities underpin key ecosystem processes, including plant health, nutrient cycling and primary productivity. In agricultural soils, beneficial soil bacteria are often exposed to multiple stressors simultaneously, including fungicides, antibiotics, and warming temperatures. Despite their ecological importance, little is known
Matthew Kelbrick, James P. J. Hall, Siobhán O'Brien   +2 more
wiley   +1 more source

Enterococcus faecium sagA mutants have cell envelope defects influencing antibiotic resistance and bacteriophage susceptibility

Journal of Bacteriology
Enterococcus faecium is a gram-positive bacterium that is resident to the intestines of animals including humans. E. faecium is also an opportunistic pathogen that causes multidrug-resistant (MDR) infections. Bacteriophages (phages) have been proposed as
Garima Arya, Pavan Kumar Chodisetti, Juliel Espinosa, Brian C. Russo, Howard C. Hang, Breck A. Duerkop   +5 more
doaj   +1 more source

From discovery to potential application: engineering a novel M23 peptidase to combat Listeria monocytogenes

Scientific Reports
Peptidoglycan hydrolases are promising alternatives for combating pathogens due to their specificity and potent bacteriolytic activity. In this study, a novel M23 peptidase from Streptococcus thermophilus NCTC10353, designated StM23, was discovered and ...
Magdalena Kaus-Drobek, Marzena Nowacka, Magdalena Gewartowska, Małgorzata Korzeniowska nee Wiweger, Merete Rusås Jensen, Trond Møretrø, Even Heir, Elżbieta Nowak, Izabela Sabała   +8 more
doaj   +1 more source

Reduced peptidoglycan synthesis capacity impairs growth of E. coli at high salt concentration

mBio
Gram-negative bacteria have a thin peptidoglycan layer between the cytoplasmic and outer membranes protecting the cell from osmotic challenges. Hydrolases of this structure are needed to cleave bonds to allow the newly synthesized peptidoglycan strands ...
Dema Alodaini, Victor Hernandez-Rocamora, Gabriela Boelter, Xuyu Ma, Micheal B. Alao, Hannah M. Doherty, Jack A. Bryant, Patrick Moynihan, Danesh Moradigaravand, Monika Glinkowska, Waldemar Vollmer, Manuel Banzhaf   +11 more
doaj   +1 more source

Nucleotide Sequence of Conjugative Prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes

Frontiers in Microbiology, 2014
Genetic element Φ1207.3 (formerly Tn1207.3) is a prophage of Streptococcus pyogenes which carries the macrolide efflux resistance genes mef(A)/msr(D) and is capable of conjugal transfer among streptococci. Complete nucleotide sequence showed that Φ1207.3
Francesco eIannelli, Maria eSantagati, Francesco eSantoro, Marco R Oggioni, Stefania eStefani, Gianni ePozzi   +5 more
doaj   +1 more source

SpyB, a small heme-binding protein, affects the composition of the cell wall in Streptococcus pyogenes

Frontiers in Cellular and Infection Microbiology, 2016
Streptococcus pyogenes (Group A Streptococcus or GAS) is a haemolytic human pathogen associated with a wide variety of infections ranging from minor skin and throat infections to life-threatening invasive diseases.
Rebecca J Edgar, Jing Chen, Sashi Kant, Elena Rechkina, Jeffrey S Rush, Lennart Scott Forsberg, Bernhard Jaehrig, Parastoo Azadi, Veronika Tchesnokova, Evgeni V Sokurenko, Haining Zhu, Konstantin V Korotkov, Vijay Pancholi, Natalia Korotkova   +13 more
doaj   +1 more source

Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis.

PLoS Pathogens, 2017
Enterococcus faecalis is an opportunistic pathogen frequently isolated in clinical settings. This organism is intrinsically resistant to several clinically relevant antibiotics and can transfer resistance to other pathogens. Although E.
Bartłomiej Salamaga, Tomasz K Prajsnar, Ana Jareño-Martinez, Joost Willemse, Martin A Bewley, Françoise Chau, Tassadit Ben Belkacem, Annemarie H Meijer, David H Dockrell, Stephen A Renshaw, Stéphane Mesnage   +10 more
doaj   +1 more source

Functional profiling of CHAP domain-containing peptidoglycan hydrolases of Staphylococcus aureus USA300 uncovers potential targets for anti-staphylococcal therapies

International Journal of Medical Microbiology
The bacterial pathogen Staphylococcus aureus employs a thick cell wall for protection against physical and chemical insults. This wall requires continuous maintenance to ensure strength and barrier integrity, but also to permit bacterial growth and ...
Min Wang, Xiaofang Li, Francis M. Cavallo, Harita Yedavally, Sjouke Piersma, Elisa J.M. Raineri, Elias Vera Murguia, Jeroen Kuipers, Zhenhua Zhang, Jan Maarten van Dijl, Girbe Buist   +10 more
doaj   +1 more source

A probiotic bi-functional peptidoglycan hydrolase sheds NOD2 ligands to regulate gut homeostasis in female mice. [PDF]

Nat Commun, 2023
Gao J, Wang L, Jiang J, Xu Q, Zeng N, Lu B, Yuan P, Sun K, Zhou H, He X.   +9 more
europepmc   +1 more source

Enhancing stability and safety of chimeric peptidoglycan hydrolases by linker engineering

Applied Microbiology and Biotechnology
Abstract Spread of antimicrobial resistance and lack of new antibiotics have brought attention to alternative strategies of combating pathogenic bacteria. One of these strategies takes advantage of the bacteriolytic activity of peptidoglycan hydrolases.
Mitkowski, Paweł, Jagielska, Elżbieta, Korzeniowska nee Wiweger, Małgorzata, Nowacka, Marzena, Kjos, Morten, Kranjec, Christian, Sabała, Izabela   +6 more
openaire   +3 more sources