Results 1 to 10 of about 33,979 (182)

Inflammatory response modulation by epinephrine and norepinephrine

RUDN Journal of Medicine, 2023
Relevance. Inflammation is a defense response of an organism to a pathogen. It appears in order to maintain homeostasis and is regulated by the immune, nervous, and endocrine systems.
Svetlana V. Guryanova, Artem S. Ferberg, Ilya A. Sigmatulin   +2 more
doaj   +1 more source

NOD-like receptors in pathogenesis of missed and spontaneous abortions

Акушерство, гинекология и репродукция, 2023
Nucleotide-binding oligomerization domain-like receptors (NOD-like receptors) are cytosolic signaling receptors of innate immune cells recognizing ligands derived from bacteria, viruses, fungi and protozoa.
O. P. Lebedeva, V. M. Ivannikova, I. O. Zhukova, O. N. Kozarenko, O. B. Altukhova, S. P. Pakhomov, M. I. Churnosov   +6 more
doaj   +1 more source

Detection of mutations in NOD2/CARD15 gene in Arab patients with Crohn's disease

The Saudi Journal of Gastroenterology, 2021
Background: Mutations in NOD2/CARD15 gene have been linked to an increased risk of Crohn's disease (CD). The objective of this study is to determine NOD2/CARD15 gene mutations, and their association with the risk of CD in Arabs in Kuwait.
Iqbal Siddique, Abu S Mustafa, Islam Khan, Ali H Ziyab, Munira Altarrah, Riyas Sulaiman, Numeer Kadungothayil, Faraz Shaheed   +7 more
doaj   +1 more source

BCG, muramylpeptides, trained immunity (part II): a low molecular weight alternative to multicomponent bacterial immunostimulants for prevention of respiratory infections during a pandemic

Терапевтический архив, 2021
During a pandemic, nonspecific immunoprophylaxis of SARS-CoV-2 infection and other acute respiratory infections (ARI), which can worsen the course of COVID-19, is increasingly in demand in addition to specific immunization.
Oleg V. Kalyuzhin, Tatiana M. Andronova, Alexander V. Karaulov   +2 more
doaj   +1 more source

Blau syndrome NOD2 mutations result in loss of NOD2 cross-regulatory function

Frontiers in Immunology, 2022
The studies described here provide an analysis of the pathogenesis of Blau syndrome and thereby the function of NOD2 as seen through the lens of its dysfunction resulting from Blau-associated NOD2 mutations in its nucleotide-binding domain (NBD). As such,
Liming Mao, Liming Mao, Atika Dhar, Guangxun Meng, Guangxun Meng, Guangxun Meng, Ivan Fuss, Kim Montgomery-Recht, Zhiqiong Yang, Qiuyun Xu, Atsushi Kitani, Warren Strober   +11 more
doaj   +1 more source

Bacterial TLR4 and NOD2 signaling linked to reduced mitochondrial energy function in active inflammatory bowel disease

Gut Microbes, 2020
Inflammatory bowel disease (IBD) has been linked to active signaling with bacterial components and reduced mitochondrial ATP production; however, synergism between both of these disease characteristics remains unclear.
Emmanuelle Ruiz, Harrison M. Penrose, Sandra Heller, Hani Nakhoul, Melody Baddoo, Erik F. Flemington, Emad Kandil, Suzana D. Savkovic   +7 more
doaj   +1 more source

BCG, muramylpeptides, trained immunity (part I): linkages in the light of the COVID-19 pandemic

Терапевтический архив, 2020
It has long been known that Bacillus CalmetteGurin (BCG) vaccine provides nonspecific protection against many non-mycobacterial infections, which has been discussed in the last decade through the prism of the concept of trained immunity.
O. V. Kalyuzhin, T. M. Andronova, A. V. Karaulov   +2 more
doaj   +1 more source

A nod to the bond between NOD2 and mycobacteria.

PLoS Pathogens, 2023
Mycobacteria are responsible for several human and animal diseases. NOD2 is a pattern recognition receptor that has an important role in mycobacterial recognition.
Jean-Yves Dubé, Marcel A Behr
doaj   +1 more source

Tofacitinib, a suppressor of NOD2 expression, is a potential treatment for Blau syndrome

Frontiers in Immunology, 2023
IntroductionBlau syndrome is a rare autosomal dominant autoinflammatory granulomatous disease caused by a mutation in the NOD2 gene. It is characterized by a clinical trial of granulomatous dermatitis, arthritis, and uveitis.
Yoko Ueki, Riko Takimoto-Ito, Megumu K. Saito, Hideaki Tanizaki, Naotomo Kambe, Naotomo Kambe   +5 more
doaj   +1 more source

Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism

Journal of Hematology & Oncology, 2021
Background Key hepatic molecules linking gut dysbiosis and hepatocarcinogenesis remain largely unknown. Gut-derived gut microbiota contains pathogen-associated molecular patterns (PAMPs) that may circulate into the liver and, consequently, be recognized ...
Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen, Ruyi Xue, Si Zhang   +12 more
doaj   +1 more source