Results 31 to 40 of about 19,932 (234)

Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. [PDF]

PLoS ONE, 2016
NOD2 contributes to the innate immune response and to the homeostasis of the intestinal mucosa. In response to its bacterial ligand, NOD2 interacts with RICK and activates the NF-κB and MAPK pathways, inducing gene transcription and synthesis of proteins
Raphaële Thiébaut, Sophie Esmiol, Patrick Lecine, Batoul Mahfouz, Aurelie Hermant, Cendrine Nicoletti, Stephane Parnis, Julie Perroy, Jean-Paul Borg, Leigh Pascoe, Jean-Pierre Hugot, Vincent Ollendorff   +11 more
doaj   +1 more source

NOD2in Crohn’s Disease—Unfinished Business

Journal of Crohn's and Colitis, 2022
AbstractStudies of Crohn’s disease have consistently implicated NOD2 as the most important gene in disease pathogenesis since first being identified in 2001. Thereafter, genome-wide association, next-generation sequencing and functional analyses have all confirmed a key role for NOD2, but despite this, NOD2 also has significant unresolved complexity ...
Ashton, James, Seaby, Eleanor, Beattie, Robert M, Ennis, Sarah   +3 more
openaire   +6 more sources

T cell intrinsic NOD2 is dispensable for CD8 T cell immunity. [PDF]

PLoS ONE, 2013
NOD2 is an intracellular pattern recognition receptor that provides innate sensing of bacterial muramyl dipeptide by host cells, such as dendritic cells, macrophages and epithelial cells. While NOD2's role as an innate pathogen sensor is well established,
Gloria H Y Lin, Michael E Wortzman, Stephen E Girardin, Dana J Philpott, Tania H Watts   +4 more
doaj   +1 more source

FRMBP2 directs NOD2 to the membrane [PDF]

Proceedings of the National Academy of Sciences, 2012
The immune system acts as a shield against harmful microbes and requires exquisite control of the activation and resolution of multiple signaling pathways. Tight regulation of these processes is required not only to produce an effective response, but also to maintain immune homeostasis and prevent autoinflammatory disease.
Amrita, Kabi, Christine, McDonald
openaire   +2 more sources

Influence of muramyl peptides on the production of chemokines, growth factors, pro-inflammatory and anti-inflammatory cytokines

RUDN Journal of Medicine
Relevance.The recent increase in inflammatory, allergic and infectious diseases needs to update new ways of raising non-specific resistance of the organism.
Svetlana V. Guryanova
doaj   +1 more source

Inborn Errors in the LRR Domain of Nod2 and Their Potential Consequences on the Function of the Receptor

Cells, 2021
The innate immune system plays a critical role in the early detection of pathogens, primarily by relying on pattern-recognition receptor (PRR) signaling molecules.
Shamila D. Alipoor, Mehdi Mirsaeidi
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

NOD2 function in Crohn's disease [PDF]

Journal of Translational Medicine, 2011
not submitted for publication Published: 23 November 2011 doi:10.1186/1479-5876-9-S2-I10 Cite this article as: Simmons: NOD2 function in Crohn’s disease. Journal of Translational Medicine 2011 9(Suppl 2):I10. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space ...
openaire   +2 more sources