Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. [PDF]
PLoS ONE, 2013 NOD2 is an intracellular pattern recognition receptor that assembles with receptor-interacting protein (RIP)-2 kinase in response to the presence of bacterial muramyl dipeptide (MDP) in the host cell cytoplasm, thereby inducing signals leading to the ...
David J Rickard +16 more
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Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation [PDF]
, 2020 International audienceThe nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5 ...
Deutsch, Eric +6 more
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The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis
BMC Infectious Diseases, 2007 Background NOD2, an intracellular pathogen recognition sensor, modulates innate defences to muropeptides derived from various bacterial species, including Mycobacterium tuberculosis (MTB). Experimentally, NOD2 attenuates two key putative mycobactericidal
Johnson Margaret A +8 more
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Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. [PDF]
PLoS ONE, 2016 NOD2 contributes to the innate immune response and to the homeostasis of the intestinal mucosa. In response to its bacterial ligand, NOD2 interacts with RICK and activates the NF-κB and MAPK pathways, inducing gene transcription and synthesis of proteins
Raphaële Thiébaut +11 more
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Trained immunity or tolerance : opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors [PDF]
, 2014 Article Accepted Date: 29 January 2014. ACKNOWLEDGMENTS D.C.I. received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement HEALTH-2010-260338 (“Fungi in the setting of inflammation, allergy and autoimmune ...
Gow, Neil A R +9 more
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T cell intrinsic NOD2 is dispensable for CD8 T cell immunity. [PDF]
PLoS ONE, 2013 NOD2 is an intracellular pattern recognition receptor that provides innate sensing of bacterial muramyl dipeptide by host cells, such as dendritic cells, macrophages and epithelial cells. While NOD2's role as an innate pathogen sensor is well established,
Gloria H Y Lin +4 more
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The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis [PDF]
, 2017 Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal disease of prematurity. Although the precise cause is not well understood, the main risk factors thought to contribute to NEC include prematurity, formula feeding, and bacterial ...
Bolock, Alexa M +2 more
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TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.
PLoS ONE, 2012 NOD2, the nucleotide-binding domain and leucine-rich repeat containing gene family (NLR) member 2 is involved in mediating antimicrobial responses. Dysfunctional NOD2 activity can lead to severe inflammatory disorders, but the regulation of NOD2 is still
Birte Zurek +10 more
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Campylobacter jejuni infection of conventionally colonized mice lacking nucleotide-oligomerization-domain-2 [PDF]
, 2017 Background The nucleotide-binding oligomerisaton protein 2 (NOD2) constitutes a pivotal sensor of bacterial muramyl dipeptide and assures expression of distinct antimicrobial peptides and mediators produced by enterocytes and immune cells directed ...
Alutis, Marie E. +4 more
core +2 more sources
Cells, 2021 The innate immune system plays a critical role in the early detection of pathogens, primarily by relying on pattern-recognition receptor (PRR) signaling molecules.
Shamila D. Alipoor, Mehdi Mirsaeidi
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