Results 31 to 40 of about 20,611 (234)

Autoinflammatory disease with focus on NOD2-associated disease in the era of genomic medicine

Autoimmunity, 2019
Systemic autoinflammatory diseases (SAIDs) represent a spectrum of genetically heterogeneous inflammatory disorders. Some SAID-associated genes are located in chromosome 16, including familial Mediterranean fever gene (MEFV) and nucleotide-binding ...
Qingping Yao, Ellen Li, Bo Shen
doaj   +1 more source

Valosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses

Scientific Reports, 2022
NOD2 polymorphisms may affect sensing of the bacterial muramyl dipeptide (MDP) and trigger perturbed inflammatory responses. Genetic screening of a patient with immunodeficiency and enteropathy revealed a rare homozygous missense mutation in the first ...
Maryam Ghalandary, Yue Li, Thomas Fröhlich, Thomas Magg, Yanshan Liu, Meino Rohlfs, Sebastian Hollizeck, Raffaele Conca, Tobias Schwerd, Holm H. Uhlig, Philip Bufler, Sibylle Koletzko, Aleixo M. Muise, Scott B. Snapper, Fabian Hauck, Christoph Klein, Daniel Kotlarz   +16 more
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Alterations in nucleotide-binding oligomerization domain-2 expression, pathway activation, and cytokine production in Yao syndrome

Autoimmunity, 2018
Yao syndrome (YAOS) is a systemic autoinflammatory disease (SAID), formerly termed nucleotide-binding oligomerization domain-2 (NOD2)-associated autoinflammatory disease.
Christine McDonald, Min Shen, Erin E. Johnson, Amrita Kabi, Qingping Yao   +4 more
doaj   +1 more source

NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages

Arthritis Research & Therapy, 2023
Objective Synovial inflammation, which precedes other pathological changes in osteoarthritis (OA), is primarily initiated by activation and M1 polarization of macrophages.
Changchuan Li, Zhuji Ouyang, Yuhsi Huang, Sipeng Lin, Shixun Li, Jing Xu, Taihe Liu, Jionglin Wu, Peidong Guo, Zhong Chen, Haoyu Wu, Yue Ding   +11 more
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Regulating the stabilities of NOD1 and NOD2, two innate immune receptors, with sugars and chaperones

, 2022
Grimes, Catherine LeimkuhlerBahnson, Brian J.A healthy human body contains as many bacterial cells as it does human cells, and while some of these bacteria are known to cause diseases, many are beneficial and vital for our well-being, comprising the ...
Drake, Walter R., III
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Control of UBE2V2 by NOD2.

, 2023
We provide evidence here from loss-of-function studies in mice and gain-of-function studies in human cells (1, 2) which demonstrate control of UBE2Q2 by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
openaire   +1 more source

DataSheet_1_Blau syndrome NOD2 mutations result in loss of NOD2 cross-regulatory function.docx

, 2022
The studies described here provide an analysis of the pathogenesis of Blau syndrome and thereby the function of NOD2 as seen through the lens of its dysfunction resulting from Blau-associated NOD2 mutations in its nucleotide-binding domain (NBD). As such,
Kim Montgomery-Recht (13798072), Warren Strober (12156236), Zhiqiong Yang (13798075), Liming Mao (231467), Qiuyun Xu (142266), Atika Dhar (4101562), Guangxun Meng (480502), Atsushi Kitani (13798078), Ivan Fuss (13798069)   +8 more
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Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. [PDF]

PLoS ONE, 2013
NOD2 is an intracellular pattern recognition receptor that assembles with receptor-interacting protein (RIP)-2 kinase in response to the presence of bacterial muramyl dipeptide (MDP) in the host cell cytoplasm, thereby inducing signals leading to the ...
David J Rickard, Clark A Sehon, Viera Kasparcova, Lorena A Kallal, Xin Zeng, Monica N Montoute, Tushar Chordia, Derek D Poore, Hu Li, Zining Wu, Patrick M Eidam, Pamela A Haile, Jong Yu, John G Emery, Robert W Marquis, Peter J Gough, John Bertin   +16 more
doaj   +1 more source

NOD2 signalling in Crohn's disease [PDF]

Gut, 2011
Introduction NOD2 is an intracellular pattern recognition receptor that induces autophagy in human dendritic cells (DCs) in a manner important for bacterial handling and antigen presentation. Variants of NOD2 associated with terminal ileal Crohn's disease (CD) fail to induce autophagy normally on Nod2 stimulation ...
Allan, P, Brain, O, Baker, J, Simpson, P, Pichulik, T, Khatamzas, E, Reenares, C, Leslie, A, Kessler, B, Simmons, A   +9 more
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Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae. [PDF]

, 2016
The innate immune system recognizes microbial pathogens via pattern recognition receptors. One such receptor, NOD2, via recognition of muramyl dipeptide (MDP), triggers a distinct network of innate immune responses, including the production of ...
Schenk, Mirjam, Belisle, John T, John T. Belisle, Choi, Aaron W, Aaron W. Choi, Brennan, Patrick J, Patrick J. Brennan, Kim, Hee Jin, Mirjam Schenk, Hee Jin Kim, Sebabrata Mahapatra, Robert L. Modlin, Mahapatra, Sebabrata, Le, Phuonganh, Phuonganh Le, Modlin, Robert L   +15 more
core   +1 more source