Results 51 to 60 of about 33,979 (182)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Macrophage autophagy in atherosclerosis [PDF]

, 2013
Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
Carnuccio, R., Grassia, G., Ialenti, A., Maffia, P., Maiuri, M.C., Platt, A.   +5 more
core   +2 more sources

Influence of muramyl peptides on the production of chemokines, growth factors, pro-inflammatory and anti-inflammatory cytokines

RUDN Journal of Medicine
Relevance.The recent increase in inflammatory, allergic and infectious diseases needs to update new ways of raising non-specific resistance of the organism.
Svetlana V. Guryanova
doaj   +1 more source

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis. [PDF]

PLoS ONE, 2013
Although the etiology of Crohn's disease (CD) remains elusive this disease is characterized by T cell activation that leads to chronic inflammation and mucosal damage.
Galliano Zanello, Ashleigh Goethel, Katharina Forster, Kaoru Geddes, Dana J Philpott, Kenneth Croitoru   +5 more
doaj   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells. [PDF]

, 2018
Enhancers for embryonic stem (ES) cell-expressed genes and lineage-determining factors are characterized by conventional marks of enhancer activation in ES cells1-3, but it remains unclear whether enhancers destined to regulate cell-type-restricted ...
Destici, Eugin, Friedman, Meyer, Kim, Hong Sook, Ma, Qi, Ma, Wubin, Merkurjev, Daria, Ohgi, Kenneth, Rosenfeld, Michael G, Skowronska-Krawczyk, Dorota, Suter, Tom, Tan, Yuliang   +10 more
core   +2 more sources

The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses

Virulence, 2023
Microbial sensors play an essential role in maintaining cellular homoeostasis. Our knowledge is limited on how microbial sensing helps in differential immune response and its link to inflammatory diseases.
Aditi Sharma, Sajan Chandrangadhan Achi, Stella-Rita Ibeawuchi, Mahitha Shree Anandachar, Hobie Gementera, Uddeep Chaudhury, Fatima Usmani, Kevin Vega, Ibrahim M Sayed, Soumita Das   +9 more
doaj   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Upper and small bowel Crohn's disease in Brazilian children: Phenotypic characteristic and surgical risk

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Upper and small bowel Crohn's disease (U‐SBCD) represents a clinically aggressive phenotype with high complication rates yet remains diagnostically challenging. In low‐ and middle‐income countries (LMICs), limited inflammatory bowel disease (IBD) awareness contributes to diagnostic delays, but their impact on U‐SBCD outcomes remains
Jane Oba, Carlos Walter Sobrado, Elizete Aparecida Lomazi, Mariana Deboni, Michela Cynthia da Rocha Marmo, Vanessa Adriana Scheeffer, Silvio da Rocha Carvalho, Adérson Omar Mourão Cintra Damião, Matheus Freitas Cardoso de Azevedo, Carlos Frederico Sparapan Marques, Eytan Wine, Artur Figueiredo Delgado, Clovis Artur Almeida da Silva Full   +12 more
wiley   +1 more source

Absence of Nucleotide-Oligomerization-Domain-2 Is Associated with Less Distinct Disease in Campylobacter jejuni Infected Secondary Abiotic IL-10 Deficient Mice [PDF]

, 2017
Human Campylobacter jejuni-infections are progressively increasing worldwide. Despite their high prevalence and socioeconomic impact the underlying mechanisms of pathogen-host-interactions are only incompletely understood.
Alutis, Marie E., Bereswill, Stefan, Fischer, André, Grundmann, Ursula, Heimesaat, Markus M.   +4 more
core   +2 more sources