Results 51 to 60 of about 19,932 (234)
Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response
The FEBS Journal, EarlyView.Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril +2 more
wiley +1 more source
Genetic aspects of inflammatory bowel diseases: current views
Клинический разбор в общей медицинеThe article examines modern ideas about the genetic aspects of inflammatory bowel disease (IBD), a group of chronic pathologies including ulcerative colitis and Crohn's disease.
Elena N. Kostyukova +7 more
doaj +1 more source
The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses
Virulence, 2023 Microbial sensors play an essential role in maintaining cellular homoeostasis. Our knowledge is limited on how microbial sensing helps in differential immune response and its link to inflammatory diseases.
Aditi Sharma +9 more
doaj +1 more source
Autoimmunity and Periodontitis
Journal of Periodontal Research, EarlyView.In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga +2 more
wiley +1 more source
Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy. [PDF]
PLoS ONE, 2014 NOD2, one of the cytosolic proteins that contain a nuclear oligomerization domain (NOD), is a pattern recognition receptor (PRR) involved in innate immune responses to intracellular pathogens. Little is known, however, about the effect of NOD2 expression
Yuan-yuan Zhang +9 more
doaj +1 more source
P907 NOD2 mutations are associated with the development of inflammatory and progressive digestive tract damage in Crohn’s disease [PDF]
, 2023 S. Behnisch +7 more
openalex +1 more source
Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence
Journal of Periodontal Research, EarlyView.This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo +3 more
wiley +1 more source
Scientific Reports, 2017 Genetics plays a central role in susceptibility to obesity and metabolic diseases. BALB/c mice are known to be resistant to high fat diet (HFD)-induced obesity, however the genetic cause remains unknown.
Ivan Rodriguez-Nunez +5 more
doaj +1 more source
Periodontology 2000, EarlyView.Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng +4 more
wiley +1 more source
Association of the TLR4 and NOD2 Polymorphisms with Childhood Acute Lymphoblastic Leukemia
Bezmiâlem Science, 2018 Objective:Immune activation plays a critical role in the immune response against cancer. Although several genetic factors are established with regard to the development of acute lymphoblastic leukemia (ALL), the role of immunogenic genes in ALL ...
Bahadır BATAR +4 more
doaj +1 more source