Results 71 to 80 of about 19,932 (234)

NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson’s disease

Journal of Neuroinflammation, 2018
Background In Parkinson’s disease (PD), loss of striatal dopaminergic (DA) terminals and degeneration of DA neurons in the substantia nigra (SN) are associated with inflammation. Nucleotide-binding oligomerization domain-containing protein (NOD)2, one of
Li Cheng, Lin Chen, Xinbing Wei, Yimeng Wang, Zhiping Ren, Shenglan Zeng, Xiumei Zhang, Haitao Wen, Chengjiang Gao, Huiqing Liu   +9 more
doaj   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, Volume 13, Issue 39, 13 July 2026.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis

The Scientific World Journal, 2016
Nucleotide-binding oligomerization domain-containing protein (Nod) 2 is an intracellular pattern recognition receptor, which recognizes muramyl dipeptide (N-Acetylmuramyl-L-Alanyl-D-Isoglutamine: MDP), a bacterial peptidoglycan component, and makes a NF ...
Tomoyuki Iwasaki, Naoe Kaneko, Yuki Ito, Hiroyuki Takeda, Tatsuya Sawasaki, Toshio Heike, Kiyoshi Migita, Kazunaga Agematsu, Atsushi Kawakami, Shinnosuke Morikawa, Sho Mokuda, Mie Kurata, Junya Masumoto   +12 more
doaj   +1 more source

NOD2 Deficiency Protects against Cardiac Remodeling after Myocardial Infarction in Mice

Cellular Physiology and Biochemistry, 2013
Background/Aims: Although the pathogenesis of myocardial infarction (MI) is multifactorial, activation of innate immune system to induce inflammation has emerged as a key pathophysiological process in MI.
Xiang Li, Fengli Li, Yongli Chu, Xiaojie Wang, Hongyu Zhang, Yanyan Hu, Yan Zhang, Ziying Wang, Xinbing Wei, Wencheng Jian, Xiumei Zhang, Fan Yi   +11 more
doaj   +1 more source

NOD2: Ethnic and geographic differences

World Journal of Gastroenterology, 2006
Investigations into the inheritance of the three risk alleles R702W, G908R and 1007fsInsC in NOD2 associated with susceptibility to Crohn's disease have demonstrated a remarkable amount of heterogeneity across ethnicities and populations, with regional variation across Europe for example, suggesting local founder effects.
openaire   +2 more sources

Inhibiting Peptidoglycan Hydrolase Alleviates MRSA Pneumonia Through Autolysin-Mediated MDP-NOD2 Pathway

Infection and Drug Resistance
Yang Yang,1,2 Zongze Yao,1 Jiazhen Zhang,1 Wei Shao,3 Bo Li,2 Huihui Wu,2 Wenjian Tang,3 Jing Zhang2 1School of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 2Anhui Province Key Laboratory of Occupational ...
Yang Y, Yao Z, Zhang J, Shao W, Li B, Wu H, Tang W, Zhang J   +7 more
doaj  

Evidence of allelic heterogeneity for associations between the NOD2/CARD15 gene and ulcerative colitis among North Indians [PDF]

, 2007
Garima Juyal, Devendra Amre, Vandana Midha, Ajit Sood, Ernest G. Seidman, B.K. Thelma   +5 more
openalex   +1 more source

The NLRP3 inflammasome mediates DSS-induced intestinal inflammation in knockout mice

Innate Immunity, 2019
Crohn’s disease (CD) is a chronic disorder of the gastrointestinal tract characterized by inflammation and intestinal epithelial injury. Loss of function mutations in the intracellular bacterial sensor NOD2 are major risk factors for the development of ...
Benjamin Umiker, Hyun-Hee Lee, Julia Cope, Nadim J. Ajami, Jean-Philippe Laine, Christine Fregeau, Heidi Ferguson, Stephen E Alves, Nunzio Sciammetta, Melanie Kleinschek, Michael Salmon   +10 more
doaj   +1 more source

Absence of Nucleotide-Oligomerization-Domain-2 Is Associated with Less Distinct Disease in Campylobacter jejuni Infected Secondary Abiotic IL-10 Deficient Mice

Frontiers in Cellular and Infection Microbiology, 2017
Human Campylobacter jejuni-infections are progressively increasing worldwide. Despite their high prevalence and socioeconomic impact the underlying mechanisms of pathogen-host-interactions are only incompletely understood.
Markus M. Heimesaat, Ursula Grundmann, Marie E. Alutis, André Fischer, Stefan Bereswill   +4 more
doaj   +1 more source