Results 91 to 100 of about 20,611 (234)

Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations

, 2005
AIM: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD. METHODS: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included.
Gasztonyi, Beáta, Mózsik, Gyula, Oesterreicher, Christoph, Szalay, Ferenc, Willheim-Polli, Claudia, Reinisch, Walter, Papp, János, Lakatos, Péter László, Molnár, Tamás, Altorjay, István, Tulassay, Zsolt, Ferenci, Péter, Lakatos, László   +12 more
core  

Age-of-onset-dependent influence of NOD2 gene variants on disease behaviour and treatment in Crohn's disease [PDF]

, 2013
BACKGROUND: Influence of genetic variants in the NOD2 gene may play a more important role in disease activity, behaviour and treatment of pediatric- than adult-onset Crohn's disease (CD).
Pfalzer, Veronika, Niess, Jan Hendrik, Klaus, Jochen, von Boyen, Georg BT, Posovszky, Carsten, Lahr, Georgia, Mayer, Benjamin, Debatin, Klaus-Michael   +7 more
core   +1 more source

IRGM variants and susceptibility to inflammatory bowel disease in the German population. [PDF]

, 2013
Genome-wide association studies identified the autophagy gene IRGM to be strongly associated with Crohn's disease (CD) but its impact in ulcerative colitis (UC), its phenotypic effects and potential epistatic interactions with other IBD susceptibility ...
Darina Czamara, Seiderer, J., Goke, B., Eleni Tsekeri (276693), Stephanie Bues, Fries, C., Julia Seiderer (107820), Beigel, F., Glas, J., Friedrich, Matthias, Christian Steib (174731), Czamara, D., Jürgen Glas (107816), Stephanie Bues (276692), Bues, S., Eleni Tsekeri, Stallhofer, Johannes, Torsten Olszak (107835), Brand, Stephan, Florian Beigel (174724), Beigel, Florian, Matthias Friedrich (174721), Stallhofer, J., Johannes Stallhofer, Matthias Friedrich, Wetzke, M., Darina Czamara (107824), Stephan Brand (107861), Julia Diegelmann, Steib, Christian, Göke, Burkhard, Fries, Christoph, Friedrich, M., Seiderer, Julia, Glas, Jürgen, Tsekeri, E., Diegelmann, J., Burkhard Göke (109829), Christoph Fries, Martin Wetzke, Burkhard Göke, Christian Steib, Stephan Brand, Tsekeri, Eleni, Brand, S., Steib, C., Czamara, Darina, Martin Wetzke (107833), Julia Diegelmann (107830), Bues, Stephanie, Jürgen Glas, Wetzke, Martin, Diegelmann, Julia, Christoph Fries (174714), Johannes Stallhofer (174728), Torsten Olszak, Olszak, T., Florian Beigel, Julia Seiderer, Olszak, Torsten   +59 more
core   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, Volume 59, Issue 7, Page 1402-1415, July 2026.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

Polyphosphates Attenuate Interleukin‐12 Production in Macrophages Infected With Legionella pneumophila

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Legionella pneumophila infection leads to the release of pathogen‐associated molecular patterns, which recruits the adaptor protein MYD88, initiating both activating (e.g., NF‐κB) and inhibitory (e.g., PI3K/AKT) signaling pathways that regulate IL‐12 gene expression.
Kara Vasilew, Archana Jayaraman, Johannes Platten, Shuang Xu, Sarah Josinsky, Julian Roewe, Maximilian Mimmler, Jonathan Kilroy, Fedoua Echahidi, Ziya Kaya, Dario S. Zamboni, Christoph Reinhardt, Markus Bosmann   +12 more
wiley   +1 more source

Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis

The Scientific World Journal, 2016
Nucleotide-binding oligomerization domain-containing protein (Nod) 2 is an intracellular pattern recognition receptor, which recognizes muramyl dipeptide (N-Acetylmuramyl-L-Alanyl-D-Isoglutamine: MDP), a bacterial peptidoglycan component, and makes a NF ...
Tomoyuki Iwasaki, Naoe Kaneko, Yuki Ito, Hiroyuki Takeda, Tatsuya Sawasaki, Toshio Heike, Kiyoshi Migita, Kazunaga Agematsu, Atsushi Kawakami, Shinnosuke Morikawa, Sho Mokuda, Mie Kurata, Junya Masumoto   +12 more
doaj   +1 more source

NOD2 Deficiency Protects against Cardiac Remodeling after Myocardial Infarction in Mice

Cellular Physiology and Biochemistry, 2013
Background/Aims: Although the pathogenesis of myocardial infarction (MI) is multifactorial, activation of innate immune system to induce inflammation has emerged as a key pathophysiological process in MI.
Xiang Li, Fengli Li, Yongli Chu, Xiaojie Wang, Hongyu Zhang, Yanyan Hu, Yan Zhang, Ziying Wang, Xinbing Wei, Wencheng Jian, Xiumei Zhang, Fan Yi   +11 more
doaj   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

NOD2: Ethnic and geographic differences

World Journal of Gastroenterology, 2006
Investigations into the inheritance of the three risk alleles R702W, G908R and 1007fsInsC in NOD2 associated with susceptibility to Crohn's disease have demonstrated a remarkable amount of heterogeneity across ethnicities and populations, with regional variation across Europe for example, suggesting local founder effects.
openaire   +2 more sources

Development and functional adaptation of intestinal macrophages across the lifespan

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
This article discusses intestinal macrophage development, including the influence of developmental origins and life stages; ontogeny and functional heterogeneity; preclinical and clinical evidence. Abstract Macrophages of the gastrointestinal system are central regulators of gut development, homeostasis and disease, yet their origin, functional ...
Baha Mustafa, Elisa L Hill‐Yardin, Sarah J Spencer   +2 more
wiley   +1 more source