Results 101 to 110 of about 33,979 (182)

Staphylococcal peptidoglycan co-localizes with Nod2 and TLR2 and activates innate immune response via both receptors in primary murine keratinocytes.

PLoS ONE, 2010
In mammalian host cells staphylococcal peptidoglycan (PGN) is recognized by Nod2. Whether PGN is also recognized by TLR2 is disputed. Here we carried out PGN co-localization and stimulation studies with TLR2 and Nod2 in wild type and mutant host cells ...
Maria Anna Müller-Anstett, Patrick Müller, Till Albrecht, Mulugeta Nega, Jeanette Wagener, Qiang Gao, Susanne Kaesler, Martin Schaller, Tilo Biedermann, Friedrich Götz   +9 more
doaj   +1 more source

NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated CarcinogenesisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host immune response including epithelial and immune cells. The association
Audrey Ferrand, Ziad Al Nabhani, Núria Solà Tapias, Emmanuel Mas, Jean-Pierre Hugot, Frédérick Barreau   +5 more
doaj   +1 more source

Late Onset Telomere Biology Disorder Presenting With Pancytopenia, Immune Dysregulation, Interstitial Lung Disease and Alopecia

American Journal of Hematology, Volume 101, Issue 6, Page 1196-1200, June 2026.
Bo A. Wan, Hamish Nicolson, Heather A. Leitch, Ryan J. Stubbins, Luke Y. C. Chen, Timothy Murray, Amy Trottier, Anthony Gador   +7 more
wiley   +1 more source

NOD2 reduces the chemoresistance of melanoma by inhibiting the TYMS/PLK1 signaling axis

Cell Death and Disease
Nucleotide-binding oligomerization domain 2 (NOD2) is an immune sensor crucial for eliciting the innate immune responses. Nevertheless, discrepancies exist regarding the effect of NOD2 on different types of cancer.
Fang Yun, Na Wu, Xiaojia Yi, Xuedan Zhang, Yu Feng, Qinxuan Ni, Yanlong Gai, Enjiang Li, Zhe Yang, Qiao Zhang, Buqing Sai, Yingmin Kuang, Yuechun Zhu   +12 more
doaj   +1 more source

NOD2 AND THE INNATE IMMUNE DEFENSE [PDF]

, 2005
The innate immune response is the first barrier against external stimuli arising from disease-causing pathogens. The primary membrane associated Toll-Like receptors (TLRs) play an important role in the innate immune response by recognizing pathogen ...
Bo, Meihua
core  

Transcription of NOD1 and NOD2 and their interaction with CARD9 and RIPK2 in IFN signaling in a perciform fish, the Chinese perch, Siniperca chuatsi

Frontiers in Immunology
NOD1 and NOD2 as two representative members of nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family play important roles in antimicrobial immunity.
Xue Yun Peng, Xue Yun Peng, Kai Lun Wang, Li Li, Bo Li, Xiang Yang Wu, Zhi Wei Zhang, Nan Li, Lan Hao Liu, P. Nie, P. Nie, P. Nie, Shan Nan Chen   +12 more
doaj   +1 more source

Ripk2 Dictates Nod2 Mediated Chemotherapy Resistance Through Inhibiting Pyroptosis

International Dental Journal
Aim or purpose: Cisplatin resistance in HNSCC remains a major therapeutic challenge. Evidence suggests that intratumoral microbiota modulates chemotherapy resistance by reshaping the tumor microenvironment, yet the underlying mechanisms and targeted ...
Xin Guo
doaj   +1 more source

Attenuating ABHD17 Isoforms Augments the S-acylation and Function of NOD2 and a Subset of Crohn’s Disease-associated NOD2 VariantsSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: NOD2 is an intracellular innate immune receptor that detects bacterial peptidoglycan fragments. Although nominally soluble, some NOD2 is associated with the plasma membrane and endosomal compartments for microbial surveillance ...
Charneal L. Dixon, Noah R. Martin, Micah J. Niphakis, Benjamin F. Cravatt, Gregory D. Fairn   +4 more
doaj   +1 more source

Large liquid rocket engine transient performance simulation system [PDF]

Phase 1 of the Rocket Engine Transient Simulation (ROCETS) program consists of seven technical tasks: architecture; system requirements; component and submodel requirements; submodel implementation; component implementation; submodel testing and ...
Mason, J. R., Southwick, R. D.
core   +1 more source

Blau syndrome with atrophoderma vermiculata-like appearance: a case report. [PDF]

Front Immunol
Zheng J, Sun J.
europepmc   +1 more source