Results 111 to 120 of about 20,611 (234)

Novel NOD2 haplotype strengthens the association between TLR4 Asp299Gly and Crohn's disease in an Australian population.

, 2008
Background: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic, debilitating disorder.
E. Hume, Georgia, Griffiths, Lyn, Simms, Lisa, H.J. Florin, Timothy, V. Fowler, Elizabeth, Fowler, EV, Palmieri, Orazio, Griffiths, Lyn R., Florin, Timothy H., Palmieri, O, L. Radford-Smith, Graham, Florin, THJ, Fowler, Elizabeth V., Huang, Ning, Simms, Lisa A., Hume, GE, Annese, V, Hume, Georgia E., Annese, Vito, Doecke, J, Radford-Smith, GL, Griffiths, LR, Doecke, James, Radford-Smith, Graham L., Huang, N, Simms, LA, Huang, Nina   +26 more
core   +1 more source

Nod2: a critical regulator of ileal microbiota and Crohn’s disease

Frontiers in Immunology, 2016
The human intestinal tract harbors large bacterial community consisting of commensal, symbiotic and pathogenic strains, which are constantly interacting with the intestinal immune system.
Tabasum Sidiq, Sayuri Yoshihama, Isaac Downs, Koichi S Kobayashi   +3 more
doaj   +1 more source

Long‐term echocardiographic findings in patients with idiopathic recurrent pericarditis treated with anakinra

Internal Medicine Journal, Volume 56, Issue 6, Page 1043-1050, June 2026.
Abstract Aim Idiopathic recurrent pericarditis (IRP) is considered an autoinflammatory disease, and interleukin 1 inhibitors, such as anakinra, are used to treat resistant cases. Constrictive pericarditis, a feared complication, continues to be a critical concern. In the biologic era, evidence on long‐term transthoracic echocardiographic (TTE) findings
Zeynep Toker Dincer, Damla Raimoglou, Erkin Yilmaz, Ayten Dag, Melike Melikoglu, Serdal Ugurlu   +5 more
wiley   +1 more source

NOD2 WT localizes to the nucleus whereas NOD2 K305R or NOD1 do not.

, 2012
A) Indirect immunofluorescence micrographs of HeLa cells grown on coverslips and expressing myc-NOD2 WT (top) or myc-NOD2 K305R (bottom) were treated with 50 nM leptomycine B (LMB) for 4 h or left untreated. Images with signals for DAPI, TRIM27, myc-NOD2
Maria Lerm (150166), Germana Meroni (150170), Birte Zurek (150135), Johan D. Söderholm (150174), Thomas A. Kufer (150176), Ida Schoultz (150141), Katharina Birkner (150156), Andreas Neerincx (150147), Luisa M. Napolitano (150152), Eveline Bennek (150160), Gernot Sellge (150163)   +10 more
core   +1 more source

Staphylococcal peptidoglycan co-localizes with Nod2 and TLR2 and activates innate immune response via both receptors in primary murine keratinocytes.

PLoS ONE, 2010
In mammalian host cells staphylococcal peptidoglycan (PGN) is recognized by Nod2. Whether PGN is also recognized by TLR2 is disputed. Here we carried out PGN co-localization and stimulation studies with TLR2 and Nod2 in wild type and mutant host cells ...
Maria Anna Müller-Anstett, Patrick Müller, Till Albrecht, Mulugeta Nega, Jeanette Wagener, Qiang Gao, Susanne Kaesler, Martin Schaller, Tilo Biedermann, Friedrich Götz   +9 more
doaj   +1 more source

Molecular characterization of CCKR in Ctenopharyngodon idella and its involvement in the intestinal immune response to bacterial challenges

Journal of the World Aquaculture Society, Volume 57, Issue 3, June 2026.
Abstract Cholecystokinin receptor (CCKR), an important recognition receptor for the gastrointestinal hormone cholecystokinin (CCK) in the endocrine system, plays a crucial role in regulating immune responses in mammals. In this study, a novel cholecystokinin receptor (CiCCKR) was identified from the grass carp Ctenopharyngodon idella.
Ran Peng, Jingjing Yang, Huilan Mo, Miao Zhang, Xin Li, Xia Zhang, Meixing Guo, Kelan Jin, Fufa Qu, Jianzhong Li, Yunyun Zeng, Xixun Zhou, Zhuangwen Mao, Zhen Liu, Jianzhou Tang   +14 more
wiley   +1 more source

NOD2 interaction with distinct NLRP members.

, 2013
Upper panel, A “+” indicates an interaction, “−” symbolizes no interaction (n.d.: not done). A short isoform of NOD2 (NOD2-S, residues 1–180), maintains the interaction with NLRP1, -3, and -12.
Robert Schwarzenbacher (45566), Thomas A. Kufer (150176), Roland N. Wagner (197690), Martina Proell (45563)   +3 more
core   +1 more source

Late Onset Telomere Biology Disorder Presenting With Pancytopenia, Immune Dysregulation, Interstitial Lung Disease and Alopecia

American Journal of Hematology, Volume 101, Issue 6, Page 1196-1200, June 2026.
Bo A. Wan, Hamish Nicolson, Heather A. Leitch, Ryan J. Stubbins, Luke Y. C. Chen, Timothy Murray, Amy Trottier, Anthony Gador   +7 more
wiley   +1 more source

NOD2 and Mycobacteria

, 2010
The genus Mycobacterium comprises a variety of highly successful intracellular pathogens. Mycobacterium tuberculosis is the causative agent of tuberculosis (TB) in humans and currently infects one third of the world's population. Mycobacterium avium ssp.
Coulombe, François
core  

p62 co-localizes with NOD2 through the NBD domain of NOD2.

, 2013
A. HEK293T cells were transfected for 24 h with scramble siRNA (left top panel), si-p62 (right top panel), and GFP-NOD2. GFP-NOD2 was visualized using confocal microscopy as described in “Methods”. B.
Macon Coleman (379865), Sangwook Park (379863), Soon-Duck Ha (379864), Shahab Meshkibaf (379866), Sung Ouk Kim (379867)   +4 more
core   +1 more source