Results 121 to 130 of about 20,611 (234)

NOD2 reduces the chemoresistance of melanoma by inhibiting the TYMS/PLK1 signaling axis

Cell Death and Disease
Nucleotide-binding oligomerization domain 2 (NOD2) is an immune sensor crucial for eliciting the innate immune responses. Nevertheless, discrepancies exist regarding the effect of NOD2 on different types of cancer.
Fang Yun, Na Wu, Xiaojia Yi, Xuedan Zhang, Yu Feng, Qinxuan Ni, Yanlong Gai, Enjiang Li, Zhe Yang, Qiao Zhang, Buqing Sai, Yingmin Kuang, Yuechun Zhu   +12 more
doaj   +1 more source

Interaction of distinct NOD2 mutants with RIPK2.

, 2013
Left panel, Yeast two-hybrid analysis. NOD2 CARD1+2 interacts with RIPK2 CARD (column 1). No interactions were observed for NOD2 variants harboring a disrupted acidic patch (transformation 2, 3, and 4). An unrelated mutation not affecting the interaction
Robert Schwarzenbacher (45566), Thomas A. Kufer (150176), Roland N. Wagner (197690), Martina Proell (45563)   +3 more
core   +1 more source

Razvoj novih agonistov NOD2 in dvojnih agonistov NOD2 in TLR7 kot novih adjuvansov za cepiva

, 2022
Vaccination, one of the most effective medical interventions ever introduced, primes the immune system to respond to future infections, dramatically reducing the morbidity and mortality of many infectious diseases.
Guzelj, Samo
core  

Transcription of NOD1 and NOD2 and their interaction with CARD9 and RIPK2 in IFN signaling in a perciform fish, the Chinese perch, Siniperca chuatsi

Frontiers in Immunology
NOD1 and NOD2 as two representative members of nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family play important roles in antimicrobial immunity.
Xue Yun Peng, Xue Yun Peng, Kai Lun Wang, Li Li, Bo Li, Xiang Yang Wu, Zhi Wei Zhang, Nan Li, Lan Hao Liu, P. Nie, P. Nie, P. Nie, Shan Nan Chen   +12 more
doaj   +1 more source

Crohn's disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli.

, 2008
Contains fulltext : 69346.pdf (Publisher’s version ) (Open Access)Mutations in nucleotide-binding oligomerization domain-2 (NOD2), leading to defective recognition of bacterial peptidoglycans, are associated with Crohn's disease.
Kullberg, B.J., Drenth, J.P.H., Dirk J. de Jong, Meer, J.W.M. van der, Bart Jan Kullberg, Joosten, L.A.B., Netea, M.G., Jos W. M. Van der Meer, Leo A. B. Joosten, Gerben Ferwerda, Jong, D. de, Joost P. H. Drenth, Ferwerda, G., Mihai G. Netea   +13 more
core   +1 more source

NOD2: Ethnic and geographic differences [PDF]

, 2015
Investigations into the inheritance of the three risk alleles; R702W, G908R and 1007fsInsC in NOD2 associated with susceptibility to Crohn's disease have demonstrated a remarkable amount of heterogeneity across ethnicities and populations, with regional ...
Cavanaugh, Juleen
core  

Ripk2 Dictates Nod2 Mediated Chemotherapy Resistance Through Inhibiting Pyroptosis

International Dental Journal
Aim or purpose: Cisplatin resistance in HNSCC remains a major therapeutic challenge. Evidence suggests that intratumoral microbiota modulates chemotherapy resistance by reshaping the tumor microenvironment, yet the underlying mechanisms and targeted ...
Xin Guo
doaj   +1 more source

p62 stabilizes gMDP-induced NOD2 oligomers.

, 2013
A. HEK293T cells were stably transfected with pLNCX-NOD2 as described in “Methods”. These cells were treated with scramble (si-Scramble) or p62 targeting (si-p62) small interference RNAs for 24 h.
Macon Coleman (379865), Sangwook Park (379863), Soon-Duck Ha (379864), Shahab Meshkibaf (379866), Sung Ouk Kim (379867)   +4 more
core   +1 more source

Attenuating ABHD17 Isoforms Augments the S-acylation and Function of NOD2 and a Subset of Crohn’s Disease-associated NOD2 VariantsSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: NOD2 is an intracellular innate immune receptor that detects bacterial peptidoglycan fragments. Although nominally soluble, some NOD2 is associated with the plasma membrane and endosomal compartments for microbial surveillance ...
Charneal L. Dixon, Noah R. Martin, Micah J. Niphakis, Benjamin F. Cravatt, Gregory D. Fairn   +4 more
doaj   +1 more source

NOD2-NLRP3 Axis and Asthma

Journal of Asthma and Allergy
Patients with asthma frequently experience recurrent symptoms including coughing, wheezing, shortness of breath, and chest tightness. Asthma is a common public health concern. It is characterized by chronic airway inflammation. However, The pathogenesis of asthma is complex. Inflammasomes are signaling platforms that regulate the inflammatory response.
openaire   +4 more sources