Insights into the molecular basis of the NOD2 signalling pathway [PDF]
Open Biology, 2014 The cytosolic pattern recognition receptor NOD2 is activated by the peptidoglycan fragment muramyl dipeptide to generate a proinflammatory immune response.
Joseph P. Boyle +2 more
doaj +6 more sources
NOD2-C2 - a novel NOD2 isoform activating NF-κB in a muramyl dipeptide-independent manner [PDF]
BMC Research Notes, 2010 Background The innate immune system employs several receptor families that form the basis of sensing pathogen-associated molecular patterns. NOD (nucleotide-binding and oligomerization domain) like receptors (NLRs) comprise a group of cytosolic proteins ...
Kramer Marcel +7 more
doaj +3 more sources
NOD2 Promotes Glioblastoma Progression Through Effects on Epithelial–Mesenchymal Transition and Cancer Stemness [PDF]
BiomedicinesBackground: Glioblastoma multiforme (GBM) represents one of the most aggressive and lethal primary brain malignancies, characterized by rapid proliferation, extensive invasiveness, and a dismal prognosis.
Eshrat Jahan +10 more
doaj +2 more sources
PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. [PDF]
, 2012 Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (
Achkar, Jean-Paul +14 more
core +15 more sources
Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection [PDF]
, 2014 Enteropathogenic and enterohemorrhagic bacterial infections in humans are a severe cause of morbidity and mortality. Although NOD-like receptors (NLRs) NOD2 and NLRP3 have important roles in the generation of protective immune responses to enteric ...
Anand, Paras K +6 more
core +8 more sources
NOD2 and inflammation: current insights [PDF]
, 2018 The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory ...
Cucchiara, Salvatore +3 more
core +2 more sources
Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations [PDF]
, 2005 AIM: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD. METHODS: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included.
Altorjay, István +12 more
core +1 more source
Novel Scaffolds for Modulation of NOD2 Identified by Pharmacophore-Based Virtual Screening
Biomolecules, 2022 Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an innate immune pattern recognition receptor responsible for the recognition of bacterial peptidoglycan fragments.
Samo Guzelj +2 more
doaj +1 more source
Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients [PDF]
, 2003 The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn's disease represents an important step towards the delineation of the immuno-pathogenesis of inflammatory bowel disease.
Folwaczny, Christian +3 more
core +1 more source
Nod2 Deficiency in mice is Associated with Microbiota Variation Favouring the Expansion of mucosal CD4+ LAP+ Regulatory Cells [PDF]
, 2018 Nucleotide-binding Oligomerization Domain-2 (NOD2) mutations are associated with an increased risk to develop Crohn's Disease. In previous studies, we have shown that Nod2-/- mice manifest increased proportion of Lamina Propria (LP) CD4+ LAP+ Foxp3 ...
Boirivant, M. +9 more
core +3 more sources