Results 11 to 20 of about 20,611 (234)
Nod2: The intestinal gate keeper.
PLoS Pathogens, 2017 Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan (PGN)-conserved motifs in cytosol and stimulates host immune response. The association of NOD2 mutations with a number
Ziad Al Nabhani +3 more
doaj +8 more sources
NOD2 and inflammation: current insights [PDF]
Journal of Inflammation Research, 2018 The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory transcriptional program and other innate immune pathways, including autophagy and endoplasmic reticulum ...
Negroni, Anna +3 more
core +8 more sources
Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain [PDF]
FEBS Letters, 2014 NOD2 activation by muramyl dipeptide causes a proinflammatory immune response in which the adaptor protein CARD9 works synergistically with NOD2 to drive p38 and c‐Jun N‐terminal kinase (JNK) signalling. To date the nature of the interaction between NOD2 and CARD9 remains undetermined.
Parkhouse, Rhiannon +5 more
openaire +4 more sources
NOD2-C2 - a novel NOD2 isoform activating NF-κB in a muramyl dipeptide-independent manner
BMC Research Notes, 2010 Background The innate immune system employs several receptor families that form the basis of sensing pathogen-associated molecular patterns. NOD (nucleotide-binding and oligomerization domain) like receptors (NLRs) comprise a group of cytosolic proteins ...
Kramer Marcel +7 more
doaj +2 more sources
NOD2in Crohn’s Disease—Unfinished Business
Journal of Crohn's and Colitis, 2022 AbstractStudies of Crohn’s disease have consistently implicated NOD2 as the most important gene in disease pathogenesis since first being identified in 2001. Thereafter, genome-wide association, next-generation sequencing and functional analyses have all confirmed a key role for NOD2, but despite this, NOD2 also has significant unresolved complexity ...
Ashton, James +3 more
openaire +7 more sources
TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation. [PDF]
PLoS ONE, 2012 NOD2, the nucleotide-binding domain and leucine-rich repeat containing gene family (NLR) member 2 is involved in mediating antimicrobial responses. Dysfunctional NOD2 activity can lead to severe inflammatory disorders, but the regulation of NOD2 is still
Birte Zurek +10 more
doaj +2 more sources
Scientific Reports, 2017 Genetics plays a central role in susceptibility to obesity and metabolic diseases. BALB/c mice are known to be resistant to high fat diet (HFD)-induced obesity, however the genetic cause remains unknown.
Ivan Rodriguez-Nunez +5 more
doaj +2 more sources
Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells. [PDF]
PLoS ONE, 2011 BackgroundGenetic and environmental factors influence susceptibility to Crohn's disease (CD): NOD2 is the strongest individual genetic determinant and smoking the best-characterised environmental factor.
Marian C Aldhous +6 more
doaj +2 more sources
, 2006 The NOD-LRR (nucleotide-binding oligomerization domain, leucine-rich repeat) family of proteins in mammals form part of a wider, extremely well conserved pathogen detection system that includes the CED (cell death abnormality) proteins in C. elegans and the pathogen-detecting disease resistance (R) proteins in plants. The mammalian NOD-LRR protein Nod2
Barry, Guy
openaire +2 more sources
NOD2 signalling in hidradenitis suppurativa [PDF]
Clinical and Experimental Dermatology, 2021 Hidradenitis suppurativa (HS) is associated with dysregulated immune responses including altered expression of cytokines, chemokines, and antimicrobial peptides and proteins (AMPs).To evaluate the expression of nucleotide-binding oligomerization domain-containing (NOD)2 and related factors in HS skin samples and keratinocyte cultures.We performed real ...
T. Gambichler +5 more
openaire +3 more sources