Results 11 to 20 of about 19,932 (234)

Nod2: The intestinal gate keeper.

PLoS Pathogens, 2017
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan (PGN)-conserved motifs in cytosol and stimulates host immune response. The association of NOD2 mutations with a number
Ziad Al Nabhani, Gilles Dietrich, Jean-Pierre Hugot, Frederick Barreau   +3 more
doaj   +7 more sources

NOD2 signalling in hidradenitis suppurativa [PDF]

Clinical and Experimental Dermatology, 2021
Hidradenitis suppurativa (HS) is associated with dysregulated immune responses including altered expression of cytokines, chemokines, and antimicrobial peptides and proteins (AMPs).To evaluate the expression of nucleotide-binding oligomerization domain-containing (NOD)2 and related factors in HS skin samples and keratinocyte cultures.We performed real ...
T. Gambichler, S. Hessam, M. Skrygan, M. Bakirtzi, D. Kasakovski, F. G. Bechara   +5 more
openaire   +3 more sources

NOD2 and inflammation: current insights

Journal of Inflammation Research, 2018
The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory transcriptional program and other innate immune pathways, including autophagy and endoplasmic reticulum ...
Negroni A, Pierdomenico M, Cucchiara S, Stronati L   +3 more
openalex   +7 more sources

NOD2 regulation of micrornas [PDF]

Gut, 2011
Introduction Crohn's Disease (CD) is thought to arise both from defects in the gut mucosal barrier and from a dysregulated Th1/ Th17 immune response to commensal gut flora. CARD15 polymorphisms confer susceptibility to terminal ileal CD.
Brain, O, Allan, P, Pichulik, T, Khatamzas, E, Simpson, P, Jewell, D, Simmons, A   +6 more
openaire   +2 more sources

Tofacitinib, a suppressor of NOD2 expression, is a potential treatment for Blau syndrome

Frontiers in Immunology, 2023
IntroductionBlau syndrome is a rare autosomal dominant autoinflammatory granulomatous disease caused by a mutation in the NOD2 gene. It is characterized by a clinical trial of granulomatous dermatitis, arthritis, and uveitis.
Yoko Ueki, Riko Takimoto-Ito, Megumu K. Saito, Hideaki Tanizaki, Naotomo Kambe, Naotomo Kambe   +5 more
doaj   +1 more source

Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism

Journal of Hematology & Oncology, 2021
Background Key hepatic molecules linking gut dysbiosis and hepatocarcinogenesis remain largely unknown. Gut-derived gut microbiota contains pathogen-associated molecular patterns (PAMPs) that may circulate into the liver and, consequently, be recognized ...
Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen, Ruyi Xue, Si Zhang   +12 more
doaj   +1 more source

Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain [PDF]

FEBS Letters, 2014
NOD2 activation by muramyl dipeptide causes a proinflammatory immune response in which the adaptor protein CARD9 works synergistically with NOD2 to drive p38 and c‐Jun N‐terminal kinase (JNK) signalling. To date the nature of the interaction between NOD2 and CARD9 remains undetermined.
Parkhouse, Rhiannon, Boyle, Joseph P, Mayle, Sophie, Sawmynaden, Kovilen, Rittinger, Katrin, Monie, Tom P   +5 more
openaire   +2 more sources

Insights into the molecular basis of the NOD2 signalling pathway [PDF]

Open Biology, 2014
The cytosolic pattern recognition receptor NOD2 is activated by the peptidoglycan fragment muramyl dipeptide to generate a proinflammatory immune response.
Joseph P. Boyle, Rhiannon Parkhouse, Tom P. Monie   +2 more
doaj   +1 more source

Novel Scaffolds for Modulation of NOD2 Identified by Pharmacophore-Based Virtual Screening

Biomolecules, 2022
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an innate immune pattern recognition receptor responsible for the recognition of bacterial peptidoglycan fragments.
Samo Guzelj, Tihomir Tomašič, Žiga Jakopin   +2 more
doaj   +1 more source

Autoinflammatory disease with focus on NOD2-associated disease in the era of genomic medicine

Autoimmunity, 2019
Systemic autoinflammatory diseases (SAIDs) represent a spectrum of genetically heterogeneous inflammatory disorders. Some SAID-associated genes are located in chromosome 16, including familial Mediterranean fever gene (MEFV) and nucleotide-binding ...
Qingping Yao, Ellen Li, Bo Shen
doaj   +1 more source