Results 21 to 30 of about 19,932 (234)
Autoimmunity, 2018 Yao syndrome (YAOS) is a systemic autoinflammatory disease (SAID), formerly termed nucleotide-binding oligomerization domain-2 (NOD2)-associated autoinflammatory disease.
Christine McDonald +4 more
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NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages
Arthritis Research & Therapy, 2023 Objective Synovial inflammation, which precedes other pathological changes in osteoarthritis (OA), is primarily initiated by activation and M1 polarization of macrophages.
Changchuan Li +11 more
doaj +1 more source
Scientific Reports, 2022 NOD2 polymorphisms may affect sensing of the bacterial muramyl dipeptide (MDP) and trigger perturbed inflammatory responses. Genetic screening of a patient with immunodeficiency and enteropathy revealed a rare homozygous missense mutation in the first ...
Maryam Ghalandary +16 more
doaj +1 more source
, 2023 We provide evidence here from loss-of-function studies in mice and gain-of-function studies in human cells (1, 2) which demonstrate control of UBE2Q2 by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
openaire +1 more source
TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.
PLoS ONE, 2012 NOD2, the nucleotide-binding domain and leucine-rich repeat containing gene family (NLR) member 2 is involved in mediating antimicrobial responses. Dysfunctional NOD2 activity can lead to severe inflammatory disorders, but the regulation of NOD2 is still
Birte Zurek +10 more
doaj +1 more source
, 2023 We provide evidence here from loss-of-function studies in mice and gain-of-function studies in human cells (1, 2) which demonstrate control of CDKN1A-interacting zinc finger protein 1, CIZ1, by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
openaire +1 more source
Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. [PDF]
PLoS ONE, 2013 NOD2 is an intracellular pattern recognition receptor that assembles with receptor-interacting protein (RIP)-2 kinase in response to the presence of bacterial muramyl dipeptide (MDP) in the host cell cytoplasm, thereby inducing signals leading to the ...
David J Rickard +16 more
doaj +1 more source
Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 The immune system is exquisitely balanced. It has the ability to effectively respond to and control infections while at the same time preventing inappropriate responses to self and environmental antigens. When this response goes awry, either through a failure to activate the immune response, or failure to terminate it, inflammatory pathology results ...
Tigno-Aranjuez, Justine T. +1 more
openaire +2 more sources
NOD2 signalling in Crohn's disease [PDF]
Gut, 2011 Introduction NOD2 is an intracellular pattern recognition receptor that induces autophagy in human dendritic cells (DCs) in a manner important for bacterial handling and antigen presentation. Variants of NOD2 associated with terminal ileal Crohn's disease (CD) fail to induce autophagy normally on Nod2 stimulation ...
Allan, P +9 more
openaire +1 more source
The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis
BMC Infectious Diseases, 2007 Background NOD2, an intracellular pathogen recognition sensor, modulates innate defences to muropeptides derived from various bacterial species, including Mycobacterium tuberculosis (MTB). Experimentally, NOD2 attenuates two key putative mycobactericidal
Johnson Margaret A +8 more
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