Results 21 to 30 of about 20,611 (234)

NOD2 regulation of micrornas [PDF]

Gut, 2011
Introduction Crohn's Disease (CD) is thought to arise both from defects in the gut mucosal barrier and from a dysregulated Th1/ Th17 immune response to commensal gut flora. CARD15 polymorphisms confer susceptibility to terminal ileal CD.
Brain, O, Allan, P, Pichulik, T, Khatamzas, E, Simpson, P, Jewell, D, Simmons, A   +6 more
openaire   +2 more sources

Tofacitinib, a suppressor of NOD2 expression, is a potential treatment for Blau syndrome

Frontiers in Immunology, 2023
IntroductionBlau syndrome is a rare autosomal dominant autoinflammatory granulomatous disease caused by a mutation in the NOD2 gene. It is characterized by a clinical trial of granulomatous dermatitis, arthritis, and uveitis.
Yoko Ueki, Riko Takimoto-Ito, Megumu K. Saito, Hideaki Tanizaki, Naotomo Kambe, Naotomo Kambe   +5 more
doaj   +1 more source

Common NOD2/CARD15 variants are not associated with susceptibility or the clinicopathologic characteristics of sporadic colorectal cancer in Hungarian patients [PDF]

, 2007
Background: Epidemiological observations suggest that cancer arises from chronically inflamed tissues. Inflammatory bowel disease (IBD) is a typical example as patients with longstanding IBD are at an increased risk for developing colorectal cancer (CRC)
Zinober Kerstin, Kerstin Zinober, Gemela, Orsolya, Veres, Gábor, Peter Ferenci, Fischer, Simon, Orsolya Gemela, Papp, János, Janos Papp, Ferenci Peter, Peter Fuszek, Gemela Orsolya, Szalay Ferenc, Erika Hitre, Osztovits, János, Fischer Simon, Szalay, Ferenc, Fuszek, Péter, Ferenc Szalay, Veres Gabor, Janos Osztovits, Laszlo Lakatos, Zinober, Kerstin, Hitre, Erika, Osztovits Janos, Peter Laszlo Lakatos, Lakatos, Péter László, Hitre Erika, Lakatos Laszlo, Papp Janos, Simon Fischer, Lakatos Peter, Ferenci, Péter, Lakatos, László, Fuszek Peter, Gabor Veres   +35 more
core   +1 more source

Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism

Journal of Hematology & Oncology, 2021
Background Key hepatic molecules linking gut dysbiosis and hepatocarcinogenesis remain largely unknown. Gut-derived gut microbiota contains pathogen-associated molecular patterns (PAMPs) that may circulate into the liver and, consequently, be recognized ...
Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen, Ruyi Xue, Si Zhang   +12 more
doaj   +1 more source

Functional and biochemical characterization of Nod2 and Hsp70, important proteins involved in Crohn's disease

, 2022
Grimes, Catherine LeimkuhlerMicrobes are detected by specific host pattern recognition receptors (PRR) through the pathogen-associated molecular patterns (PAMPs).
Mohanan, Vishnu
core   +1 more source

The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants [PDF]

, 2010
Background: The aims were to analyze two novel NOD2 variants (rs2066843 and rs2076756) in a large cohort of patients with inflammatory bowel disease and to elucidate phenotypic consequences.
Darina Czamara, Seiderer, J., Seiderer Julia, Ochsenkühn, Thomas, Laubender, R. P., Beigel, F., Rüdiger P Laubender, Laubender, R., Glas, J., Müller-Myhsok, B., Czamara, D., Bertram Müller-Myhsok, Diegelmann Julia, Tillack, Cornelia, Pfennig Simone, Brand, Stephan, Göke, B., Brand Stephan, Thomas Ochsenkühn, Olszak Torsten, Weidinger Maria, Beigel, Florian, Weidinger, Maria, Ochsenkühn, T., Jürgens, Matthias, Jürgens, M., Cornelia Tillack, Julia Diegelmann, Beigel Florian, Müller-Myhsok Bertram, Jürgens Matthias, Göke, Burkhard, Pfennig, S., Pfennig, Simone, Peter Lohse, Seiderer, Julia, Glas, Jürgen, Laubender, Rüdiger P., Diegelmann, J., Lohse, P., Ochsenkühn Thomas, Müller-Myhsok, Bertram, Weidinger, M., Rüdiger P. Laubender, Burkhard Göke, Göke Burkhard, Stephan Brand, Laubender Rüdiger P., Maria Weidinger, Brand, S., Czamara, Darina, Jürgen Glas, Tillack Cornelia, Matthias Jürgens, Czamara Darina, Lohse, Peter, Diegelmann, Julia, Simone Pfennig, Glas Jürgen, Torsten Olszak, Olszak, T., Florian Beigel, Lohse Peter, Julia Seiderer, Olszak, Torsten, Tillack, C.   +65 more
core   +1 more source

Structure-Activity Relationship in NOD2 Agonistic Muramyl Dipeptides

, 2023
Nucleotide-binding oligomerization domain 2 (NOD2) is a receptor of the innate immune system that is capable of perceiving bacterial and viral infections.
Aarzoo, Kamboj, Nikolai, Petrovsky, Madhuri, Patil, Deepak, Salunke   +3 more
core   +1 more source

Insights into the molecular basis of the NOD2 signalling pathway [PDF]

Open Biology, 2014
The cytosolic pattern recognition receptor NOD2 is activated by the peptidoglycan fragment muramyl dipeptide to generate a proinflammatory immune response.
Joseph P. Boyle, Rhiannon Parkhouse, Tom P. Monie   +2 more
doaj   +1 more source

Novel Scaffolds for Modulation of NOD2 Identified by Pharmacophore-Based Virtual Screening

Biomolecules, 2022
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an innate immune pattern recognition receptor responsible for the recognition of bacterial peptidoglycan fragments.
Samo Guzelj, Tihomir Tomašič, Žiga Jakopin   +2 more
doaj   +1 more source

Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients [PDF]

, 2003
The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn's disease represents an important step towards the delineation of the immuno-pathogenesis of inflammatory bowel disease.
Folwaczny, Christian, Török, H. P., Lohse, P., Glas, J.   +3 more
core   +1 more source