NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages
Arthritis Research & Therapy, 2023 Objective Synovial inflammation, which precedes other pathological changes in osteoarthritis (OA), is primarily initiated by activation and M1 polarization of macrophages.
Changchuan Li +11 more
doaj +1 more source
Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP. [PDF]
, 2019 Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracellular bacteria and viruses, and in many cases this disruption of cellular function activates pathways of the unfolded protein response (UPR).
Atluri, Vidya L +14 more
core +1 more source
Scientific Reports, 2022 NOD2 polymorphisms may affect sensing of the bacterial muramyl dipeptide (MDP) and trigger perturbed inflammatory responses. Genetic screening of a patient with immunodeficiency and enteropathy revealed a rare homozygous missense mutation in the first ...
Maryam Ghalandary +16 more
doaj +1 more source
Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll"? [PDF]
, 2006 The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various environmental and host (e.g. genetic-, epithelial-, immune and non-immune) factors are involved.
Fischer, Simon +4 more
core +1 more source
The mid-infrared spectrum of the transiting exoplanet HD 209458b [PDF]
, 2007 We report the spectroscopic detection of mid-infrared emission from the transiting exoplanet HD 209458b. Using archive data taken with the Spitzer/IRS instrument, we have determined the spectrum of HD 209458b between 7.46 and 15.25 microns.
Akeson, R. +4 more
core +2 more sources
Autoinflammatory disease with focus on NOD2-associated disease in the era of genomic medicine
Autoimmunity, 2019 Systemic autoinflammatory diseases (SAIDs) represent a spectrum of genetically heterogeneous inflammatory disorders. Some SAID-associated genes are located in chromosome 16, including familial Mediterranean fever gene (MEFV) and nucleotide-binding ...
Qingping Yao, Ellen Li, Bo Shen
doaj +1 more source
Influence of Crohn’s disease related polymorphisms in innate immune function on ileal microbiome [PDF]
, 2019 We have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome (“dysbiosis”) in a patient cohort.
Ciorba, Matthew A +13 more
core +3 more sources
Autoimmunity, 2018 Yao syndrome (YAOS) is a systemic autoinflammatory disease (SAID), formerly termed nucleotide-binding oligomerization domain-2 (NOD2)-associated autoinflammatory disease.
Christine McDonald +4 more
doaj +1 more source
Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli. [PDF]
, 2016 Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
McCole, Declan F, Shawki, Ali
core +1 more source
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core +1 more source