Results 31 to 40 of about 11,952 (167)

In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA). [PDF]

PLoS Pathogens, 2017
The O-acetylation of the essential cell wall polymer peptidoglycan occurs in most Gram-positive bacterial pathogens, including species of Staphylococcus, Streptococcus and Enterococcus. This modification to peptidoglycan protects these pathogens from the
David Sychantha, Carys S Jones, Dustin J Little, Patrick J Moynihan, Howard Robinson, Nicola F Galley, David I Roper, Christopher G Dowson, P Lynne Howell, Anthony J Clarke   +9 more
doaj   +1 more source

A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens. [PDF]

Science, 2016
The intestinal microbiome modulates host susceptibility to enteric pathogens, but the specific protective factors and mechanisms of individual bacterial species are not fully characterized. We show that secreted antigen A (SagA) from Enterococcus faecium is sufficient to protect Caenorhabditis elegans
Rangan KJ, Pedicord VA, Wang YC, Kim B, Lu Y, Shaham S, Mucida D, Hang HC.   +7 more
europepmc   +4 more sources

Prediction of peptidoglycan hydrolases- a new class of antibacterial proteins [PDF]

BMC Genomics, 2016
The efficacy of antibiotics against bacterial infections is decreasing due to the development of resistance in bacteria, and thus, there is a need to search for potential alternatives to antibiotics. In this scenario, peptidoglycan hydrolases can be used as alternate antibacterial agents due to their unique property of cleaving peptidoglycan cell wall ...
Sharma, Ashok K., Kumar, Sanjiv, K., Harish, Dhakan, Darshan B., Sharma, Vineet K.   +4 more
openaire   +2 more sources

Coordinated and Distinct Roles of Peptidoglycan Carboxypeptidases DacC and DacA in Cell Growth and Shape Maintenance under Stress Conditions

Microbiology Spectrum, 2023
Peptidoglycan (PG) is an essential bacterial architecture pivotal for shape maintenance and adaptation to osmotic stress. Although PG synthesis and modification are tightly regulated under harsh environmental stresses, few related mechanisms have been ...
Umji Choi, Si Hyoung Park, Han Byeol Lee, Ji Eun Son, Chang-Ro Lee   +4 more
doaj   +1 more source

Two New M23 Peptidoglycan Hydrolases With Distinct Net Charge [PDF]

Frontiers in Microbiology, 2021
Bacterial peptidoglycan hydrolases play an essential role in cell wall metabolism during bacterial growth, division, and elongation (autolysins) or in the elimination of closely related species from the same ecological niche (bacteriocins). Most studies concerning the peptidoglycan hydrolases present in Gram-positive bacteria have focused on clinically
Alicja Wysocka, Elżbieta Jagielska, Łukasz Łężniak, Izabela Sabała   +3 more
openaire   +3 more sources

Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus [PDF]

Applied Microbiology and Biotechnology, 2012
Bacteria of the genus Staphylococcus are common pathogens responsible for a broad spectrum of human and animal infections and belong to the most important etiological factors causing food poisoning. Because of rapid increase in the prevalence of isolation of staphylococci resistant to many antibiotics, there is an urgent need for the development of new
Szweda, Piotr, Schielmann, Marta, Kotlowski, Roman, Gorczyca, Grzegorz, Zalewska, Magdalena, Milewski, Slawomir   +5 more
openaire   +2 more sources

Chitinase A, a tightly regulated virulence factor of Salmonella enterica serovar Typhimurium, is actively secreted by a Type 10 Secretion System.

PLoS Pathogens, 2023
As a facultative intracellular pathogen, Salmonella enterica serovar Typhimurium is one of the leading causes of food-borne diseases in humans. With the ingestion of fecal contaminated food or water, S. Typhimurium reaches the intestine.
Lena Krone, Larissa Faass, Martina Hauke, Christine Josenhans, Tobias Geiger   +4 more
doaj   +1 more source

Potential Role of the Host-Derived Cell-Wall Binding Domain of Endolysin CD16/50L as a Molecular Anchor in Preservation of Uninfected Clostridioides difficile for New Rounds of Phage Infection

Microbiology Spectrum, 2022
Endolysin is a phage-encoded cell-wall hydrolase which degrades the peptidoglycan layer of the bacterial cell wall. The enzyme is often expressed at the late stage of the phage lytic cycle and is required for progeny escape.
Wichuda Phothichaisri, Surang Chankhamhaengdecha, Tavan Janvilisri, Jirayu Nuadthaisong, Tanaporn Phetruen, Robert P. Fagan, Sittinan Chanarat   +6 more
doaj   +1 more source

O-glycosylation as a novel control mechanism of peptidoglycan hydrolase activity. [PDF]

J Biol Chem, 2013
Acm2, the major autolysin of Lactobacillus plantarum, is a tripartite protein. Its catalytic domain is surrounded by an O-glycosylated N-terminal region rich in Ala, Ser, and Thr (AST domain), which is of low complexity and unknown function, and a C-terminal region composed of five SH3b peptidoglycan (PG) binding domains.
Rolain T, Bernard E, Beaussart A, Degand H, Courtin P, Egge-Jacobsen W, Bron PA, Morsomme P, Kleerebezem M, Chapot-Chartier MP, Dufrêne YF, Hols P.   +11 more
europepmc   +7 more sources

Coordinated peptidoglycan synthases and hydrolases stabilize the bacterial cell wall

Nature Communications, 2023
Abstract Peptidoglycan (PG) defines cell shape and protects bacteria against osmotic stress. The growth and integrity of PG require coordinated actions between synthases that insert new PG strands and hydrolases that generate openings to allow the insertion.
Huan Zhang, Srutha Venkatesan, Emily Ng, Beiyan Nan   +3 more
openaire   +3 more sources