Results 11 to 20 of about 20,249 (205)
The hydrolase LpqI primes mycobacterial peptidoglycan recycling [PDF]
Nature Communications, 2019 Bacterial growth and division require remodelling of the cell wall, which generates free peptidoglycan fragments. Here, Moynihan et al. show that Mycobacterium tuberculosis can recycle components of their peptidoglycan, and characterise a crucial enzyme ...
Patrick J. Moynihan +7 more
doaj +4 more sources
A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens. [PDF]
Science, 2016 The intestinal microbiome modulates host susceptibility to enteric pathogens, but the specific protective factors and mechanisms of individual bacterial species are not fully characterized. We show that secreted antigen A (SagA) from Enterococcus faecium is sufficient to protect Caenorhabditis elegans
Rangan KJ +7 more
europepmc +6 more sources
Identification of key peptidoglycan hydrolases for morphogenesis, autolysis, and peptidoglycan composition of
Microbial Cell Factories, 2012 Background Lactobacillus plantarum is commonly used in industrial fermentation processes. Selected strains are also marketed as probiotics for their health beneficial effects.
Rolain Thomas +6 more
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Prediction of peptidoglycan hydrolases- a new class of antibacterial proteins [PDF]
BMC Genomics, 2016 Comparison of performance of the three approaches using known 250 peptidoglycan hydrolases.
Ashok K. Sharma +4 more
core +13 more sources
eLife, 2022 The helical shape of Helicobacter pylori cells promotes robust stomach colonization; however, how the helical shape of H. pylori cells is determined is unresolved.
Sophie R Sichel +2 more
doaj +1 more source
mBio, 2023 Most bacterial cell envelopes contain a cell wall layer made of peptidoglycan. The synthesis of new peptidoglycan is critical for cell growth, division, and morphogenesis and is also coordinated with peptidoglycan hydrolysis to accommodate the new ...
Michelle Wang +2 more
doaj +1 more source
Bacterial peptidoglycan (murein) hydrolases [PDF]
FEMS Microbiology Reviews, 2008 Most bacteria have multiple peptidoglycan hydrolases capable of cleaving covalent bonds in peptidoglycan sacculi or its fragments. An overview of the different classes of peptidoglycan hydrolases and their cleavage sites is provided. The physiological functions of these enzymes include the regulation of cell wall growth, the turnover of peptidoglycan ...
Vollmer W, Joris B, Charlier P, Foster S
openaire +3 more sources
Structure-based inhibitor design for reshaping bacterial morphology
Communications Biology, 2022 Peptidoglycan hydrolase 3 (Pgp3) inhibitors are designed that can change the helical morphology of Campylobacter jejuni to rod-shaped and decrease its virulence.
Yuri Choi +13 more
doaj +1 more source
A holin/peptidoglycan hydrolase‐dependent protein secretion system [PDF]
Molecular Microbiology, 2020 AbstractGram‐negative bacteria have evolved numerous pathways to secrete proteins across their complex cell envelopes. Here, we describe a protein secretion system that uses a holin membrane protein in tandem with a cell wall‐editing enzyme to mediate the secretion of substrate proteins from the periplasm to the cell exterior.
Tracy Palmer +4 more
openaire +3 more sources
Two New M23 Peptidoglycan Hydrolases With Distinct Net Charge [PDF]
Frontiers in Microbiology, 2021 Bacterial peptidoglycan hydrolases play an essential role in cell wall metabolism during bacterial growth, division, and elongation (autolysins) or in the elimination of closely related species from the same ecological niche (bacteriocins). Most studies concerning the peptidoglycan hydrolases present in Gram-positive bacteria have focused on clinically
Alicja Wysocka +3 more
openaire +3 more sources