Secreted antigen A peptidoglycan hydrolase is essential for Enterococcus faecium cell separation and priming of immune checkpoint inhibitor therapy [PDF]
eLifeEnterococcus faecium is a microbiota species in humans that can modulate host immunity (Griffin and Hang, 2022), but has also acquired antibiotic resistance and is a major cause of hospital-associated infections (Van Tyne and Gilmore, 2014).
Steven Klupt +8 more
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Multilevel Regulation of Peptidoglycan Dynamics in Bacteria: From Molecular Mechanisms to Applied Perspectives [PDF]
BiomoleculesPeptidoglycan, a crucial constituent of the bacterial cell envelope, is essential for maintaining cellular integrity and morphology. Elucidating the regulatory processes that coordinate its biosynthesis and turnover not only addresses a fundamental ...
Chang Dong +4 more
doaj +2 more sources
LytF contributes to pilus extrusion during natural competence in Streptococcus sanguinis SK36 [PDF]
Journal of BacteriologyStreptococci may enter a physiological state called competence, during which they express a specific set of genes required for exogenous DNA uptake and its subsequent integration into the genome through homologous recombination.
Rebekka Moe +4 more
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Asymmetric peptidoglycan editing generates cell curvature in Bdellovibrio predatory bacteria
Nature Communications, 2022 Cells of the predatory bacterium Bdellovibrio bacteriovorus, which invades and replicates within the periplasm of other bacteria, have a characteristic curved rod shape. Here, Banks et al.
Emma J. Banks +8 more
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Archaea produce peptidoglycan hydrolases that kill bacteria
PLOS BiologyThe social life of archaea is poorly understood. In particular, even though competition and conflict are common themes in microbial communities, there is scant evidence documenting antagonistic interactions between archaea and their abundant prokaryotic brethren: bacteria. Do archaea specifically target bacteria for destruction? If
Strock, R +6 more
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Acd, a peptidoglycan hydrolase of Clostridium difficile with N-acetylglucosaminidase activity
Microbiology, 2005 A gene encoding a putative peptidoglycan hydrolase was identified by sequence similarity searching in the Clostridium difficile 630 genome sequence, and the corresponding protein, named Acd (autolysin of C. difficile) was expressed in Escherichia coli. The deduced amino acid sequence of Acd shows a modular structure with two main domains: an N-terminal
Dhalluin, Anne +7 more
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, 2017 Most of the gene clusters encoding multiprotein complexes of the bacterial cell envelope, such as conjugation and secretion systems, Type IV pili and flagella, bear a gene encoding an enzyme with peptidoglycan hydrolase activity. These enzymes are usually glycoside hydrolases that cleave the glycan chains of the peptidoglycan.
Cascales, E., Santin, Yoann
openaire +3 more sources
Sporulation Activated via σ<sup>W</sup> Protects <i>Bacillus</i> from a Tse1 Peptidoglycan Hydrolase Type VI Secretion System Effector. [PDF]
Microbiol Spectr, 2023 Within bacterial communities, community members engage in interactions employing diverse offensive and defensive tools to reach coexistence. Extracellular-matrix production and sporulation are defensive mechanisms used by Bacillus subtilis cells when ...
Pérez-Lorente AI +3 more
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Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile. [PDF]
mBio, 2021 International audienceCell growth and division require a balance between synthesis and hydrolysis of the peptidoglycan (PG). Inhibition of PG synthesis or uncontrolled PG hydrolysis can be lethal for the cells, making it imperative to control ...
Garcia-Garcia T +11 more
europepmc +2 more sources
A probiotic bi-functional peptidoglycan hydrolase sheds NOD2 ligands to regulate gut homeostasis in female mice. [PDF]
Nat Commun, 2023 Secreted proteins are one of the direct molecular mechanisms by which microbiota influence the host, thus constituting a promising field for drug discovery.
Gao J +9 more
europepmc +2 more sources