Results 61 to 70 of about 14,172 (195)

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Homeostatic control of cell wall hydrolysis by the WalRK two-component signaling pathway in Bacillus subtilis

eLife, 2019
Bacterial cells are encased in a peptidoglycan (PG) exoskeleton that protects them from osmotic lysis and specifies their distinct shapes. Cell wall hydrolases are required to enlarge this covalently closed macromolecule during growth, but how these ...
Genevieve S Dobihal, Yannick R Brunet, Josué Flores-Kim, David Z Rudner   +3 more
doaj   +1 more source

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, EarlyView.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

An exhaustive multiple knockout approach to understanding cell wall hydrolase function in Bacillus subtilis

mBio, 2023
Most bacteria are surrounded by their cell wall, containing a highly cross-linked protective envelope of peptidoglycan. To grow, bacteria must continuously remodel their wall, inserting new material and breaking old bonds.
Sean A. Wilson, Raveen K. J. Tank, Jamie K. Hobbs, Simon J. Foster, Ethan C. Garner   +4 more
doaj   +1 more source

Phage lytic proteins: Biotechnological applications beyond clinical antimicrobials [PDF]

, 2017
Most bacteriophages encode two types of cell wall lytic proteins: endolysins (lysins) and virion-associated peptidoglycan hydrolases. Both enzymes have the ability to degrade the peptidoglycan of Gram-positive bacteria resulting in cell lysis when they ...
Donovan, David M., García Suárez, María Pilar, Gutiérrez, Diana, Martínez Fernández, Beatriz, Rodríguez González, Ana, Rodríguez, Lorena   +5 more
core   +1 more source

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

Advanced Science, EarlyView.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao, Bingyao Bai, Xingqian Ye, Yiliang Lin   +3 more
wiley   +1 more source

Insight into the Lytic Functions of the Lactococcal Prophage TP712 [PDF]

, 2019
The lytic cassette of Lactococcus lactis prophage TP712 contains a putative membrane protein of unknown function (Orf54), a holin (Orf55), and a modular endolysin with a N-terminal glycoside hydrolase (GH_25) catalytic domain and two C-terminal LysM ...
Campelo, Ana Belén, Escobedo, Susana, García, Pilar, Martínez, Beatriz, Rodríguez, Ana, Wegmann, Udo   +5 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens [PDF]

Science, 2016
The intestinal microbiome modulates host susceptibility to enteric pathogens, but the specific protective factors and mechanisms of individual bacterial species are not fully characterized. We show that secreted antigen A (SagA) from Enterococcus faecium is sufficient to protect Caenorhabditis elegans
Kavita J, Rangan, Virginia A, Pedicord, Yen-Chih, Wang, Byungchul, Kim, Yun, Lu, Shai, Shaham, Daniel, Mucida, Howard C, Hang   +7 more
openaire   +2 more sources

Structure and activity of ChiX, a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens [PDF]

, 2018
The Gram‐negative bacterium Serratia marcescens secretes a number of proteins that are involved in extracellular chitin degradation. This so‐called chitinolytic machinery includes three types of chitinase enzymes and a lytic polysaccharide monooxygenase.
Adam Lodge, Bochtler, Brurberg, Chen, Cheng, Chou, Diniz, Edwards, Emsley, Evans, Fernandes, Frank Sargent, Frederiksen, Gasteiger, Govind, Guzman, Hamilton, Hejazi, Hodak, Holm, Horn, Hoyland, Iguchi, Jacob Biboy, Jones, Joosten, Kabsch, Kabsch, Kemp, Korndörfer, Krissinel, Lewis, Maciejewska, Matthews, Murshudov, Nelson, Paul K. Fyfe, Payne, Plotka, Richard A. Owen, Sanz-Gaitero, Sharma, Skubák, Srikannathasan, Tottey, Vaaje-Kolstad, Vaaje-Kolstad, Waldemar Vollmer, William N. Hunter   +48 more
core   +2 more sources