Results 81 to 90 of about 9,126 (180)

Human Gut Phageome Analysis Uncovers Thousands of Highly Modular Endolysins

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Analysis of 9141 human gut metagenomes identified 15,267 phage genomes and 3794 highly modular endolysins. The recovered endolysins showed remarkable catalytic and cell wall–binding domain diversity, highlighting the gut phageome as a rich source of novel enzybiotics with therapeutic potential against multidrug‐resistant bacteria.
Raphael Kabir Niloy, Nurnabi Azad Jewel, Daniyal Karim, Mohimenul Haque Rolin, Tahsin Khan, Arzuba Akter, Shakhinur Islam Mondal   +6 more
wiley   +1 more source

Virulence Associated Morphology of Different Strains of Melissococcus plutonius, a Brood Pathogen of Honey Bees

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
This study explores the diversity in cell morphology and growth behaviours of three Melissococcus plutonius strains, the causative agent of European foulbrood, employing electron microscopy and expression analysis of glycan‐binding protein candidate genes. Our results illustrate the mechanism of cell separation and the formation of individual cocci and
Oleg Lewkowski, Gerd Hause, Silvio Erler
wiley   +1 more source

Third Generation Genome Sequencing of the Endobacterium Corynebacterium kroppenstedtii subsp. demodicis Reveals Details of Its Microbe‐Host‐Interaction With the Most Complex Human Commensal, Demodex folliculorum

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
The symbiotic interaction between Demodex folliculorum and Corynebacterium kroppenstedtii subsp. demodicis. Created by the author based on genomic and functional analyses presented in this work. The tripartite interaction between the human host, the mite Demodex folliculorum, and its endosymbiont Corynebacterium kroppenstedtii subsp. demodicis.
T. Steegmüller, S. Walch, S. Gschwendtner, A. Klingl, L. E. French, M. Flaig, B. M. Clanner‐Engelshofen   +6 more
wiley   +1 more source

PhiA, a Peptidoglycan Hydrolase Inhibitor of Brucella Involved in the Virulence Process [PDF]

Infection and Immunity, 2019
The peptidoglycan in Gram-negative bacteria is a dynamic structure in constant remodeling. This dynamism, achieved through synthesis and degradation, is essential because the peptidoglycan is necessary to maintain the structure of the cell but has to have enough plasticity to allow the transport and assembly of macromolecular complexes in the periplasm
del Giudice, Mariela Giselda, Romani, Alexis Mariano, Ugalde, Juan Esteban, Czibener, Cecilia   +3 more
openaire   +3 more sources

Phage Endolysin: A Way To Understand A Binding Function Of C-Terminal Domains A Mini Review

Nova Biotechnologica et Chimica, 2015
Endolysins are bacteriophage-encoded peptidoglycan hydrolases, which are synthesized in the end of phage reproduction cycle, in an infected host cell. Usually, for endolysins from phages that infect Gram-positive bacteria, a modular structure is typical.
Jarábková Veronika, Tišáková Lenka, Godány Andrej   +2 more
doaj   +1 more source

Altitude‐Associated Divergence of the Gut Microbiome in Endangered Forest Musk Deer: Evidence From Integrated Metagenomics, Metabolomics, and Culturomics

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT High‐altitude environments expose mammals and their gut symbionts to multifaceted stressors—hypoxia, cold, and intense UV radiation. Whether gut microbial communities undergo compositional restructuring in response to these stressors, and whether such restructuring carries translational value for captive conservation, remain unresolved ...
Feiyun Huang, Zexiu Zhang, Yanni Zhao, Sen Ye, Maoyuan Gan, Xuxin Li, Yele Zhang, Lei Chen, Yushuo Zhang, Lingxi Chen, Ting Wang, Jinming Huang, Xiuyue Zhang   +12 more
wiley   +1 more source

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

Molecular Microbiology, Volume 125, Issue 6, Page 506-545, June 2026.
Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall‐targeting antimicrobials, combining RNAseq and high‐resolution tiling arrays. We revealed the complexity of the CESR, the contribution of extracytoplasmic function sigma factors (ECFs) and two‐component signal transduction ...
Qian Zhang, Charlène Cornilleau, Lena Friebel, Sarah Spitzner, Raphael R. Müller, Doreen Meier, Pierre Flores, Cyprien Guérin, Pierre Nicolas, Diana Wolf, Vincent Fromion, Rut Carballido‐López, Thorsten Mascher   +12 more
wiley   +1 more source

Temperature-dependent regulation of bacterial cell division hydrolases by the coordinated action of a regulatory RNA and the ClpXP protease

The Cell Surface
A defining feature of bacteria is the peptidoglycan cell wall which provides structural integrity and prevents osmotic lysis. While peptidoglycan hydrolases are required for daughter cell separation, dysregulated cell wall degradation may result in cell ...
Viktor H. Mebus, Larissa M. Busch, Morten Børre, Tobias K. Nielsen, Martin Saxtorph Bojer, Camilla Henriksen, Maria D. Barbuti, Danae M. Angeles, Kamilla Brejndal, Stephan Michalik, Manuela Gesell Salazar, Morten Kjos, Uwe Völker, Birgitte H. Kallipolitis, Dorte Frees   +14 more
doaj   +1 more source

The Plant Pathogen Xanthomonas campestris pv. campestris Exploits N-Acetylglucosamine during Infection

mBio, 2014
N-Acetylglucosamine (GlcNAc), the main component of chitin and a major constituent of bacterial peptidoglycan, is present only in trace amounts in plants, in contrast to the huge amount of various sugars that compose the polysaccharides of the plant cell
Alice Boulanger, Claudine Zischek, Martine Lautier, Stevie Jamet, Pauline Rival, Sébastien Carrère, Matthieu Arlat, Emmanuelle Lauber   +7 more
doaj   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, Volume 13, Issue 28, 18 May 2026.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source