Results 91 to 100 of about 9,126 (180)

A new regulator of the Staphylococcus aureus peptidoglycan hydrolase Sle1

PLOS Genetics
Regulation of peptidoglycan hydrolases is crucial for bacterial cell integrity, growth and division. In the bacterial pathogen Staphylococcus aureus , the amidase Sle1 is a key autolysin required for septum splitting and daughter cell separation.
Helena Veiga, Adrian Izquierdo-Martinez, Leonor B. Marques, Mariana G. Pinho   +3 more
openaire   +2 more sources

A novel peptidoglycan deacetylase modulates daughter cell separation in E. coli.

PLoS Genetics
Peptidoglycan hydrolases facilitate bacterial cell wall growth by creating space for insertion of new material and allowing physical separation of daughter cells.
Víctor M Hernández-Rocamora, Alessandra M Martorana, Aitana Belloso, Daniel Ballesteros, Marta Zaccaria, Amilcar J Perez, Bogdan I Iorga, David Abia, Joe Gray, Eefjan Breukink, Jie Xiao, Manuel Pazos, Alessandra Polissi, Waldemar Vollmer   +13 more
doaj   +1 more source

A Single Dual-Function Enzyme Controls the Production of Inflammatory NOD Agonist Peptidoglycan Fragments by Neisseria gonorrhoeae

mBio, 2017
Neisseria gonorrhoeae gonococcus (GC) is a Gram-negative betaproteobacterium and causative agent of the sexually transmitted infection gonorrhea. During growth, GC releases lipooligosaccharide (LOS) and peptidoglycan (PG) fragments, which contribute ...
Jonathan D. Lenz, Kathleen T. Hackett, Joseph P. Dillard   +2 more
doaj   +1 more source

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

The Pathogenic Neisseria Use a Streamlined Set of Peptidoglycan Degradation Proteins for Peptidoglycan Remodeling, Recycling, and Toxic Fragment Release

Frontiers in Microbiology, 2019
Neisseria gonorrhoeae and Neisseria meningitidis release peptidoglycan (PG) fragments from the cell as the bacteria grow. For N. gonorrhoeae these PG fragments are known to cause damage to human Fallopian tube tissue in organ culture that mimics the ...
Ryan E. Schaub, Joseph P. Dillard
doaj   +1 more source

The enzymology of Streptococcus pneumoniae peptidoglycan polymerisation [PDF]

Bacterial cell survival depends on intact peptidoglycan, an extensive cell wall polymer of alternating N-acetylglucosamine and N-acetylmuramic acid residues, cross-linked by short peptides.
Abrahams, Katherine A.
core  

Peptidoglycan Degrading and Sensing Systems of Mycobacterium tuberculosis [PDF]

, 2012
Mycobacterium tuberculosis (Mtb) cell wall, built on a cross-linked sugar-peptide polymer called peptidoglycan, protects the bacterial cell from adverse environments.
Prigozhin, Daniil Markovich
core  

Proposed peptidoglycan hydrolases mechanism of Lys68.

, 2014
Lys68 hydrolyses the 1, 4-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine, through a two-step mechanism involving Glu-18 catalytic residue to cleave the peptidoglycan.
Leon D. Kluskens (640869), Maarten Walmagh (165232), Maria Teresa Neves-Petersen (113668), Joana Azeredo (165240), Viruthachalam Thiagarajan (640867), Sanna Sillankorva (640868), Hugo Oliveira (640866), Rob Lavigne (102459)   +7 more
core   +1 more source

Listeria bacteriophage peptidoglycan hydrolases feature high thermoresistance and reveal increased activity after divalent metal cation substitution [PDF]

, 2018
The ability of the bacteriophage-encoded peptidoglycan hydrolases (endolysins) to destroy Gram-positive bacteria from without makes these enzymes promising antimicrobials.
Waldherr, Florian, Loessner, Martin, Schmelcher, Mathias   +2 more
core  

Dual role for the O-acetyltransferase OatA in peptidoglycan modification and control of cell septation in Lactobacillus plantarum.

PLoS ONE, 2012
Until now, peptidoglycan O-acetyl transferases (Oat) were only described for their peptidoglycan O-acetylating activity and for their implication in the control of peptidoglycan hydrolases.
Elvis Bernard, Thomas Rolain, Blandine David, Guillaume André, Vincent Dupres, Yves F Dufrêne, Bernard Hallet, Marie-Pierre Chapot-Chartier, Pascal Hols   +8 more
doaj   +1 more source