Streptococcus suis autolysin functions as a molecular bridge for epithelial adhesion via lipoteichoic acid interaction [PDF]
Infection and ImmunityAs a zoonotic opportunistic pathogen, adhesion to the porcine upper respiratory tract epithelium is a prerequisite for Streptococcus suis serotype 2 (SS2) to breach epithelial barriers and cause systemic infections under certain conditions. In this study,
Mingxing Liu +10 more
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Autolysin Production from Chlamydomonas reinhardtii [PDF]
Bio-Protocol, 2023 Chlamydomonas reinhardtii is a model organism for various processes, from photosynthesis to cilia biogenesis, and a great chassis to learn more about biofuel production.
Justin Findinier
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Cell wall mechanical stress could coordinate septal synthesis and scission in Staphylococcus aureus [PDF]
mBioStaphylococcus aureus divides by building a septum and then splitting into two daughter cells. Scission should be coordinated with septum completion to avoid cell lysis; however, it is not known how this is achieved, or what the relative roles of ...
Sheila Hoshyaripour +4 more
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Biochemical characterization and X-ray structural and mutagenic analyses of the putative autolysin CdCwlT33800 catalytic domain from Clostridioides difficile [PDF]
Applied and Environmental MicrobiologyClostridioides difficile is a major pathogen of pseudomembranous colitis, and new antimicrobial agents are needed for its treatment. Autolysins are peptidoglycan-degrading enzymes that generally reorganize the cell wall during cell division but kill ...
Hiroshi Sekiya +3 more
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Characterization of the major autolysin (AtlC) of Staphylococcus carnosus [PDF]
BMC MicrobiologyBackground Autolysis by cellular peptidoglycan hydrolases (PGH) is a well-known phenomenon in bacteria. During food fermentation, autolysis of starter cultures can exert an accelerating effect, as described in many studies on cheese ripening. In contrast,
Maximilian Merz +3 more
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Coptis rhizome extract influence on Streptococcus pneumoniae through autolysin activation [PDF]
AMB ExpressThis study investigated the antibacterial properties of Coptis rhizome, a plant traditionally used for respiratory infections, against Streptoccus pneumonia (S. pneumoniae), for which there has been minimal empirical evidence of effectiveness.
Eon-Bee Lee, Kyubae Lee
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Inhibiting Peptidoglycan Hydrolase Alleviates MRSA Pneumonia Through Autolysin-Mediated MDP-NOD2 Pathway [PDF]
Infection and Drug ResistanceYang Yang,1,2 Zongze Yao,1 Jiazhen Zhang,1 Wei Shao,3 Bo Li,2 Huihui Wu,2 Wenjian Tang,3 Jing Zhang2 1School of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 2Anhui Province Key Laboratory of Occupational ...
Yang Y +7 more
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Recombinant PBP2a/autolysin conjugate as PLGA-based nanovaccine induced humoral responses with opsonophagocytosis activity, and protection versus methicillin-resistant Staphylococcus aureus infection [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Methicillin-resistant Staphylococcus aureus (MRSA) reasons extreme infections, can resist various conventional antimicrobial agents, and cause morbidity and mortality worldwide.
Setareh Haghighat +3 more
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Antibiotics, 2023 Chimeric lysins composed of various combinations of cell wall-lysing (enzymatic) and cell-wall-binding (CWB) domains of endolysins, autolysins, and bacteriocins have been developed as alternatives to or adjuvants of conventional antibiotics.
Jin-Mi Park +9 more
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Two New M23 Peptidoglycan Hydrolases With Distinct Net Charge
Frontiers in Microbiology, 2021 Bacterial peptidoglycan hydrolases play an essential role in cell wall metabolism during bacterial growth, division, and elongation (autolysins) or in the elimination of closely related species from the same ecological niche (bacteriocins).
Alicja Wysocka +3 more
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