Results 11 to 20 of about 5,538 (201)
mBio, 2013 Enterococcus faecium is an important multidrug-resistant nosocomial pathogen causing biofilm-mediated infections in patients with medical devices. Insight into E.
Fernanda L. Paganelli +6 more
doaj +2 more sources
Toxin release mediated by the novel autolysin Cwp19 in Clostridium difficile [PDF]
Microbial Cell, 2018 Clostridium difficile, also known as Clostriodioides difficile, is a Gram positive, spore-forming bacterium and a leading cause of antibiotic-associated diarrhea in nosocomial environments. The key virulence factors of this pathogen are two toxins, toxin
Imane El Meouche, Johann Peltier
doaj +2 more sources
Isolation and purification of a Campylobacter upsaliensis autolysin
Canadian Journal of Microbiology, 1999 Autolytic activity in the soluble and sediment fractions of sonicates of the spiral and the coccoid form of Campylobacter upsaliensis could not be demonstrated by native (nondenaturing) polyacrylamide gel electrophoresis (PAGE). Autolysins were detected, however, by using denaturing sodium dodecyl sulfate (SDS) - PAGE gels containing either purified ...
S, Santiwatanakul, N R, Krieg
openaire +3 more sources
PLoS ONE, 2023 Streptococcus pneumoniae is an important cause of fatal pneumonia in humans. These bacteria express virulence factors, such as the toxins pneumolysin and autolysin, that drive host inflammatory responses.
Ηαnnah E Wong +4 more
doaj +3 more sources
Insertional inactivation of the major autolysin gene of Streptococcus pneumoniae [PDF]
Journal of Bacteriology, 1988 The lytA gene encoding the major pneumococcal autolysin (N-acetylmuramoyl-L-alanine amidase) was inactivated by inserting the 2-kilobase MspI fragment of pE194 containing the staphylococcal ermC gene. Stable autolysis-deficient (Lyt-) mutants and their isogenic Lyt+ parents were used in experiments designed to test possible physiological functions of ...
Tomasz, A., Moreillon, P., Pozzi, G.
openaire +5 more sources
Structural basis of cell wall cleavage by a staphylococcal autolysin. [PDF]
PLoS Pathogens, 2010 The major autolysins (Atl) of Staphylococcus epidermidis and S. aureus play an important role in cell separation, and their mutants are also attenuated in virulence.
Sebastian Zoll +5 more
doaj +2 more sources
Cloning of Minor Autolysin of Streptococcus Pneumoniae
Medical Laboratory Journal, 2015 Background and Objective: Increased antibiotic resistant strains and inadequacy of current vaccines against pneumococcal infections necessitate the study of novel protein antigens.
Mahboobi, R +5 more
doaj +1 more source
Exploration of Human Skin Phageome to Reveal Endolysins and Novel Antimicrobial Peptides for Therapeutic Applications. [PDF]
MicrobiologyopenThis study uncovers diverse endolysins and novel antimicrobial peptides from the human skin phageome, highlighting their potential to target antibiotic‐resistant pathogens and disrupt virulence mechanisms, paving the way for next‐generation skin therapeutics.
Paul JK +6 more
europepmc +2 more sources
Identification and Investigation of Autolysin Genes in Clostridium saccharoperbutylacetonicum Strain N1-4 for Enhanced Biobutanol Production. [PDF]
, 2021 Biobutanol is a valuable biochemical and one of the most promising biofuels. Clostridium saccharoperbutylacetonicum N1-4 is a hyperbutanol-producing strain. However, its strong autolytic behavior leads to poor cell stability, especially during continuous
Wang, Yi +9 more
core +2 more sources
Antibiotics, 2023 Chimeric lysins composed of various combinations of cell wall-lysing (enzymatic) and cell-wall-binding (CWB) domains of endolysins, autolysins, and bacteriocins have been developed as alternatives to or adjuvants of conventional antibiotics.
Jin-Mi Park +9 more
doaj +1 more source