Characterisation of the peptidoglycan hydrolases of Listeria monocytogenes EGD [PDF]
FEMS Microbiology Letters, 2006 The peptidoglycan hydrolase profile of Listeria monocytogenes EGD has been characterised under a variety of environmental and physiological conditions, using renaturing sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The profiles show activities ranging from 29 to 186 kDa.
A M, McLaughlan, S J, Foster
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Protein complexes and proteolytic activation of the cell wall hydrolase RipA regulate septal resolution in mycobacteria. [PDF]
PLoS Pathogens, 2013 Peptidoglycan hydrolases are a double-edged sword. They are required for normal cell division, but when dysregulated can become autolysins lethal to bacteria.
Michael C Chao +7 more
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Staphylococcus aureus sacculus mediates activities of M23 hydrolases
Nature Communications, 2023 Peptidoglycan, a gigadalton polymer, functions as the scaffold for bacterial cell walls and provides cell integrity. Peptidoglycan is remodelled by a large and diverse group of peptidoglycan hydrolases, which control bacterial cell growth and division ...
Alicja Razew +6 more
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A holin/peptidoglycan hydrolase‐dependent protein secretion system [PDF]
Molecular Microbiology, 2020 AbstractGram‐negative bacteria have evolved numerous pathways to secrete proteins across their complex cell envelopes. Here, we describe a protein secretion system that uses a holin membrane protein in tandem with a cell wall‐editing enzyme to mediate the secretion of substrate proteins from the periplasm to the cell exterior.
Tracy Palmer +4 more
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More than just lysins: peptidoglycan hydrolases tailor the cell wall [PDF]
Current Opinion in Microbiology, 2011 Tsuyoshi Uehara, Thomas Bernhardt
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Antibiotics, 2021 Over the past few decades, we have witnessed a surge around the world in the emergence of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and misuse of antibiotics as well as a relative lack of new drug classes in
Katarzyna M. Danis-Wlodarczyk +2 more
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Imbalance of peptidoglycan biosynthesis alters the cell surface charge of Listeria monocytogenes
The Cell Surface, 2022 The bacterial cell wall is composed of a thick layer of peptidoglycan and cell wall polymers, which are either embedded in the membrane or linked to the peptidoglycan backbone and referred to as lipoteichoic acid (LTA) and wall teichoic acid (WTA ...
Lisa Maria Schulz +4 more
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The hydrolase LpqI primes mycobacterial peptidoglycan recycling [PDF]
Nature Communications, 2018 Abstract Growth and division by most bacteria requires remodelling and cleavage of their cell wall. A byproduct of this process is the generation of free peptidoglycan (PG) fragments known as muropeptides, which are recycled in many model organisms.
Moynihan, Patrick J. +7 more
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Characterisation of a putative M23-domain containing protein in Mycobacterium tuberculosis.
PLoS ONE, 2021 Mycobacterium tuberculosis, the causative agent of tuberculosis remains a global health concern, further compounded by the high rates of HIV-TB co-infection and emergence of multi- and extensive drug resistant TB, all of which have hampered efforts to ...
Andrea Olga Papadopoulos +4 more
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Structural basis of the novel S. pneumoniae virulence factor, GHIP, a glycosyl hydrolase 25 participating in host-cell invasion. [PDF]
PLoS ONE, 2013 Pathogenic bacteria produce a wide variety of virulence factors that are considered to be potential antibiotic targets. In this study, we report the crystal structure of a novel S.
Siqiang Niu +15 more
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