Recent Advances in Peptidoglycan Synthesis and Regulation in Bacteria
Biomolecules, 2023 Bacteria must synthesize their cell wall and membrane during their cell cycle, with peptidoglycan being the primary component of the cell wall in most bacteria.
Anne Galinier +4 more
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A holin/peptidoglycan hydrolase‐dependent protein secretion system [PDF]
Molecular Microbiology, 2020 AbstractGram‐negative bacteria have evolved numerous pathways to secrete proteins across their complex cell envelopes. Here, we describe a protein secretion system that uses a holin membrane protein in tandem with a cell wall‐editing enzyme to mediate the secretion of substrate proteins from the periplasm to the cell exterior.
Tracy Palmer +4 more
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The hydrolase LpqI primes mycobacterial peptidoglycan recycling [PDF]
Nature Communications, 2018 Abstract Growth and division by most bacteria requires remodelling and cleavage of their cell wall. A byproduct of this process is the generation of free peptidoglycan (PG) fragments known as muropeptides, which are recycled in many model organisms.
Moynihan, Patrick J. +7 more
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Staphylococcus aureus sacculus mediates activities of M23 hydrolases
Nature Communications, 2023 Peptidoglycan, a gigadalton polymer, functions as the scaffold for bacterial cell walls and provides cell integrity. Peptidoglycan is remodelled by a large and diverse group of peptidoglycan hydrolases, which control bacterial cell growth and division ...
Alicja Razew +6 more
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Antibiotics, 2021 Over the past few decades, we have witnessed a surge around the world in the emergence of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and misuse of antibiotics as well as a relative lack of new drug classes in
Katarzyna M. Danis-Wlodarczyk +2 more
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Peptidoglycan Hydrolase Fusions Maintain Their Parental Specificities [PDF]
Applied and Environmental Microbiology, 2006 ABSTRACT The increased incidence of bacterial antibiotic resistance has led to a renewed search for novel antimicrobials. Avoiding the use of broad-range antimicrobials through the use of specific peptidoglycan hydrolases (endolysins) might reduce the incidence of antibiotic-resistant pathogens worldwide.
David M, Donovan +5 more
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Imbalance of peptidoglycan biosynthesis alters the cell surface charge of Listeria monocytogenes
The Cell Surface, 2022 The bacterial cell wall is composed of a thick layer of peptidoglycan and cell wall polymers, which are either embedded in the membrane or linked to the peptidoglycan backbone and referred to as lipoteichoic acid (LTA) and wall teichoic acid (WTA ...
Lisa Maria Schulz +4 more
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Structural basis of the novel S. pneumoniae virulence factor, GHIP, a glycosyl hydrolase 25 participating in host-cell invasion. [PDF]
PLoS ONE, 2013 Pathogenic bacteria produce a wide variety of virulence factors that are considered to be potential antibiotic targets. In this study, we report the crystal structure of a novel S.
Siqiang Niu +15 more
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False positives in using the zymogram assay for identification of peptidoglycan hydrolases. [PDF]
Anal Biochem, 2018 Escobar CA, Cross TA.
europepmc +2 more sources
Characterisation of a putative M23-domain containing protein in Mycobacterium tuberculosis.
PLoS ONE, 2021 Mycobacterium tuberculosis, the causative agent of tuberculosis remains a global health concern, further compounded by the high rates of HIV-TB co-infection and emergence of multi- and extensive drug resistant TB, all of which have hampered efforts to ...
Andrea Olga Papadopoulos +4 more
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