Results 11 to 20 of about 9,126 (180)
Archaea produce peptidoglycan hydrolases that kill bacteria [PDF]
PLoS BiologyThe social life of archaea is poorly understood. In particular, even though competition and conflict are common themes in microbial communities, there is scant evidence documenting antagonistic interactions between archaea and their abundant prokaryotic brethren: bacteria. Do archaea specifically target bacteria for destruction? If
Romain Strock +6 more
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Peptidoglycan Hydrolases of Escherichia coli [PDF]
Microbiology and Molecular Biology Reviews, 2011 SUMMARYThe review summarizes the abundant information on the 35 identified peptidoglycan (PG) hydrolases ofEscherichia coliclassified into 12 distinct families, including mainly glycosidases, peptidases, and amidases. An attempt is also made to critically assess their functions in PG maturation, turnover, elongation, septation, and recycling as well as
van Heijenoort J.
exaly +6 more sources
Prediction of peptidoglycan hydrolases- a new class of antibacterial proteins [PDF]
BMC Genomics, 2016 The efficacy of antibiotics against bacterial infections is decreasing due to the development of resistance in bacteria, and thus, there is a need to search for potential alternatives to antibiotics. In this scenario, peptidoglycan hydrolases can be used as alternate antibacterial agents due to their unique property of cleaving peptidoglycan cell wall ...
Ashok K Sharma +2 more
exaly +6 more sources
Bacterial peptidoglycan (murein) hydrolases [PDF]
FEMS Microbiology Reviews, 2008 Most bacteria have multiple peptidoglycan hydrolases capable of cleaving covalent bonds in peptidoglycan sacculi or its fragments. An overview of the different classes of peptidoglycan hydrolases and their cleavage sites is provided. The physiological functions of these enzymes include the regulation of cell wall growth, the turnover of peptidoglycan ...
Vollmer W, Joris B, Charlier P, Foster S
openaire +6 more sources
Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus [PDF]
Applied Microbiology and Biotechnology, 2012 Bacteria of the genus Staphylococcus are common pathogens responsible for a broad spectrum of human and animal infections and belong to the most important etiological factors causing food poisoning. Because of rapid increase in the prevalence of isolation of staphylococci resistant to many antibiotics, there is an urgent need for the development of new
Piotr Szweda +2 more
exaly +5 more sources
False positives in using the zymogram assay for identification of peptidoglycan hydrolases [PDF]
Analytical Biochemistry, 2018 Zymogram assays have been used extensively to identify novel peptidoglycan hydrolases. In this study it is reported that the zymogram is susceptible to false positive results when highly positively charged proteins are assayed. As an example, we report on the case of the ChiZ membrane protein from the Mycobacterium tuberculosis divisome, which ...
Cristian A Escobar
exaly +5 more sources
Staphylococcus aureus sacculus mediates activities of M23 hydrolases
Nature Communications, 2023 Peptidoglycan, a gigadalton polymer, functions as the scaffold for bacterial cell walls and provides cell integrity. Peptidoglycan is remodelled by a large and diverse group of peptidoglycan hydrolases, which control bacterial cell growth and division ...
Alicja Razew +6 more
doaj +2 more sources
Coordinated peptidoglycan synthases and hydrolases stabilize the bacterial cell wall
Nature Communications, 2023 Peptidoglycan (PG) defines cell shape and protects bacteria against osmotic stress. The growth and integrity of PG require coordinated actions between synthases that insert new PG strands and hydrolases that generate openings to allow the insertion ...
Huan Zhang +3 more
doaj +3 more sources
Bacteriophage virion-associated peptidoglycan hydrolases: potential new enzybiotics [PDF]
Critical Reviews in Microbiology, 2012 Virion-associated peptidoglycan hydrolases (VAPGH) are phage-encoded lytic enzymes that locally degrade the peptidoglycan (PG) of the bacterial cell wall during infection. In contrast to endolysins, PGHs that mediate lysis of the host bacteria at the end of the lytic cycle to release of phage progeny, the action of VAPGHs generates a small hole through
Rodríguez, Lorena +4 more
openaire +4 more sources
Scientific Reports, 2020 The peptidoglycan layer is responsible for maintaining bacterial cell shape and permitting cell division. Cell wall growth is facilitated by peptidoglycan synthases and hydrolases and is potentially modulated by components of the central carbon ...
Jad Sassine +4 more
doaj +2 more sources