Results 131 to 140 of about 111,225 (303)

Cutting Edge: Primary Innate Immune Cells Respond Efficiently to Polymeric Peptidoglycan, but Not to Peptidoglycan Monomers

, 2011
The cell wall of bacteria induces proinflammatory cytokines in monocytes and neutrophils in human blood. The nature of the stimulating component of bacterial cell walls is not well understood.
Janaki K. Iyer, K. Mark Coggeshall
core   +1 more source

Uncovering Key Characteristics of Antibacterial Peptides through Machine Learning

Macromolecular Rapid Communications, EarlyView.
Machine‐learning (ML) techniques using random forest classification models revealed key characteristics that predict effective antimicrobial peptides (AMPs) targeting Gram‐negative bacteria, Gram‐positive bacteria, and mycobacteria. The ideal cLogP (<$ < $−6) and net‐charge (≤+4) threshold was the same for all three targets with variations in the ...
Jooyoung Roh, Cyrille Boyer, Priyank V. Kumar   +2 more
wiley   +1 more source

In vitro characterization of peptidoglycan-associated lipoprotein (PAL)-peptidoglycan and PAL-TolB interactions.

, 1999
International audienceThe Tol-peptidoglycan-associated lipoprotein (PAL) system of Escherichia coli is a multiprotein complex of the envelope involved in maintaining outer membrane integrity.
Loret, E., Bouveret, E, Bénédetti, H, Rigal, A, Lazdunski, C   +4 more
core  

Cooperativity of peptidoglycan synthases active in bacterial cell elongation.

, 2012
peer reviewedGrowth of the bacterial cell wall peptidoglycan sacculus requires the co-ordinated activities of peptidoglycan synthases, hydrolases and cell morphogenesis proteins, but the details of these interactions are largely unknown. We now show that
Breukink, Eefjan, Philippe, Jules, Banzhaf, Manuel, Vollmer, Waldemar, Breukink, E., Terrak, Mohammed, Zapun, A., Banzhaf, Manuel; id_orcid, van den Berg van Saparoea, Bart, Vollmer, W., Fraipont, C., Egan, A., Philippe, J., Zapun, Andre, Nguyen-Distèche, M., den Blaauwen, T.; id_orcid, Terrak, M., Banzhaf, M., van den Berg van Saparoea, B., Egan, Alexander, den Blaauwen, T., Fraipont, Claudine, den Blaauwen, Tanneke, Nguyen-Distèche, Martine   +23 more
core   +1 more source

Direct interaction between MreB and the RodA‐PBP2 complex organizes lateral cell wall synthesis in Escherichia coli

mLife, EarlyView.
Abstract The elongasome, or the Rod complex, orchestrates lateral peptidoglycan (PG) synthesis in many rod‐shaped bacteria. It consists of the actin‐like protein MreB, the PG synthase RodA‐PBP2 complex, as well as MreCD and RodZ. Although the loss or disruption of any elongasome component results in a loss of rod shape, previous studies found that a ...
Rui Zhan, Han Gong, Ying Li, Xiangdong Chen, Joe Lutkenhaus, Shishen Du   +5 more
wiley   +1 more source

Cefdinir reprograms Gram‐positive bacteria to synergize with lysozyme against superbugs

mLife, EarlyView.
Abstract Multidrug‐resistant (MDR) bacteria pose a critical global health threat, urgently requiring solutions. Cefdinir, the highest‐selling third‐generation cephalosporin but one now facing clinical obsolescence due to escalating resistance, is conventionally classified as a nascent cell wall synthesis inhibitor.
Qi Zhang, Yang Yang, Shuqi Li, Zhao Liu, Chun‐Kit Lee, Chi‐Bun Ko, Qian Zhao   +6 more
wiley   +1 more source

Modifications to the Peptidoglycan Backbone Help Bacteria To Establish Infection

, 2011
Bacterial pathogens that colonize mucosal surfaces have acquired resistance to antimicrobials that are abundant at these sites. One of the main antimicrobials present on mucosal surfaces is lysozyme, a muramidase that hydrolyzes the peptidoglycan ...
Jeffrey N. Weiser, Kimberly M. Davis
core   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source

How does leaf age affect performance? A comparative study of essential oils from young and mature Eucalyptus globulus leaves in crop protection

Pest Management Science, EarlyView.
Leaf age influences metabolomic profiling but not bioactivity of Eucalyptus globulus essential oils. Leaf age affects volatile levels of young and adult E. globulus oils, but not their bioactivity. Young leaf essential oil had higher contents of α‐ and β‐pinene. AEEO had higher levels of 1,8‐cineole and trans‐pinocarveol.
Mafalda Pinto, Cristiano Soares, Ana Cristina Figueiredo, Joana Neto, Pedro A S Sousa, Ana A R M Aguiar, Michele Narduzzi, Chiara Antonelli, Anna Maria Vettraino, Tatiana Andreani, Fernando Tavares, Fernanda Fidalgo   +11 more
wiley   +1 more source

Functional analysis of the Escherichia coli mrdA gene in melittin resistance

Frontiers in Microbiology
ObjectiveThe aim of this study is to examine the functional role and resistance mechanisms of the Escherichia coli (E. coli) peptidoglycan transpeptidase gene, mrdA, in resistance to melittin.MethodsThe resistance of E.
Chong-Yi Zhao, Xiao Li, Ting Zhao, Ying Liu, Xue-Shan Xia, Xiao-Mei Wu   +5 more
doaj   +1 more source