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Peptidoglycan hydrolases in an autolytic mutant of Salmonella typhimurium
Archives Internationales de Physiologie et de Biochimie, 1988Two peptidoglycan hydrolases were isolated from the autolytic mutant Salmonella typhimurium DA361 (envD). One of them, resistant to penicillin, was found free in the supernatant of partially purified envelopes sedimented by ultracentrifugation, and the other bound to the envelopes proved to be sensitive to the antibiotic. Both were able to hydrolyse in
R A, Pizarro, R O, Fernández, L V, Orce
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Chapter 7 Microbial peptidoglycan (murein) hydrolases
1994Publisher Summary This chapter discusses the microbial peptidoglycan (murein) hydrolases. Studies of the action of lysozyme and of other bacteriolytic enzymes revealed that the bacteriolytic action was a result of hydrolysis of specific bonds in the protective and shape-maintaining bacterial exoskeleton, the peptidoglycan (murein) sacculus of the ...
G.D. Shockman, J.-V. Höltje
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Structural Comparison and Simulation of Pneumococcal Peptidoglycan Hydrolase LytB
2016Three-dimensional structural determination combined with comprehensive comparisons with the homologs is a straightforward strategy to decipher the molecular function of an enzyme. However, in many cases it's difficult to obtain the complex structure with the substrate/ligand.
Xiao-Hui, Bai +5 more
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Identification of a novel peptidoglycan hydrolase CwlM in Mycobacterium tuberculosis
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005Mycobacterium tuberculosis is a major global pathogen whose threat has increased with the emergence of multidrug-resistant strains. The cell wall of M. tuberculosis is thick, rigid, and hydrophobic, which serves to protect the organism from the environment and makes it highly impermeable to conventional antimicrobial agents. There is little known about
Lingyi Lynn, Deng +5 more
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Crystal structure of the glycosidase family 73 peptidoglycan hydrolase FlgJ
Biochemical and Biophysical Research Communications, 2009Glycoside hydrolase (GH) categorized into family 73 plays an important role in degrading bacterial cell wall peptidoglycan. The flagellar protein FlgJ contains N- and C-terminal domains responsible for flagellar rod assembly and peptidoglycan hydrolysis, respectively. A member of family GH-73, the C-terminal domain (SPH1045-C) of FlgJ from Sphingomonas
Wataru, Hashimoto +6 more
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Intracellular Peptidoglycan Hydrolases of the Bacterium Xanthomonas campestris XL-1
Biochemistry (Moscow), 2003A system of intracellular peptidoglycan hydrolases of Xanthomonas campestris XL-1 comprises about 10 enzymes of different localization and substrate specificity. Seven enzymes (A(1)-A(7)) are localized in cytosol, one enzyme (A(8)) in periplasm, and two enzymes (A(9), A(10)) were found in the fraction of cell walls and membranes.
B V, Sitkin +3 more
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Peptidoglycan (Murein) Hydrolases: Unusual Enzymes for Unusual Substrates
1993A broad variety of both Gram-positive and Gram-negative bacteria have been shown to have the ability to dissolve themselves (autolyze), particularly under “adverse” conditions (see Ghuysen and Shockman, 1973; Daneo-Moore and Shockman, 1977; Rogers et al., 1980; Shockman and Barrett, 1983; Doyle and Koch, 1987; Holtje and Tuomanen, 1991, for reviews ...
Gerald D. Shockman +4 more
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Characterization of peptidoglycan hydrolase in Cag pathogenicity island of Helicobacter pylori
Molecular Biology Reports, 2010The Cag Type IV secretion apparatus proteins in Helicobacter pylori can mediate the injection of effector CagA protein into eukaryotic target cells. Although this apparatus forms an important pathway for bacterium-host interaction, its assembly process in vivo is poorly understood, and the proteins which contribute to break the bacterial cell walls in ...
Qiao, Zhong +7 more
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Peptidoglycan hydrolases of the Staphylococci
Journal of Infection and Chemotherapy, 1997openaire +1 more source
O-ACETYLATION AND HYDROLASES OF GONOCOCCAL PEPTIDOGLYCAN
1983Harold R. Perkins +2 more
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