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Conformationally restricted peptidomimetics
2000Peptidomimetic compounds are becoming increasing important as medicinal agents. This thesis describes the design and synthesis of a novel class of non-hydrolysable peptidomimetic isosteres, the tetrazole-based amide bond isosteres. These new structural mimics have been developed for incorporation into enzyme inhibitors and biological probes where a non-
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Hydrazino-based peptidomimetics
2015Peptide-inspired drug scaffolds having designable molecular shape and surface chemistry pattern are of particular interest. Biological function of biomolecules ; enzyme- substrate specificity, binding to receptors, protein-protein or protein-nucleic acid interactions, is determined by their specific secondary structure (helices, turns, sheets ...
Vlahoviček-Kahlina, Kristina +2 more
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Peptidomimetic toolbox for drug discovery
Chemical Society Reviews, 2020Elena Lenci, Andrea Trabocchi
exaly