Results 191 to 200 of about 12,487 (241)
Human defensin-inspired discovery of peptidomimetic antibiotics [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Antibiotics with multiple mechanisms of action and broad-spectrum are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms.
Jue Zhang, Baoli Cheng, Wuyuan Lu
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Molecular Informatics, 2020
AbstractEndogenous peptides as part of physiological processes are targets of interest when it comes to finding desirable therapeutics which are able to modulate molecular interactions. The major limits presented by peptides when they are used as drugs have motivated the research of the synthesis of peptidomimetics obtained through chemical ...
Tomasella Cristina +4 more
openaire +3 more sources
AbstractEndogenous peptides as part of physiological processes are targets of interest when it comes to finding desirable therapeutics which are able to modulate molecular interactions. The major limits presented by peptides when they are used as drugs have motivated the research of the synthesis of peptidomimetics obtained through chemical ...
Tomasella Cristina +4 more
openaire +3 more sources
Peptidomimetics and Angiogenesis
Mini-Reviews in Medicinal Chemistry, 2002Angiogenesis is the sprouting of new blood capillaries from surrounding preexisting blood vessels. This process is fundamental for embryonic development, wound healing and inflammation. In healthy adults angiogenesis is of minor importance. However, aberrant angiogenesis is essentially involved in disorders as diabetic retinopathy, rheumatoid arthritis
Ralph, Mazitschek +2 more
openaire +2 more sources
Current Opinion in Chemical Biology, 1998
Major discoveries have been made of new type-I and type-III peptidomimetic inhibitors of peptide-derived systems. Innovative reversible inhibitors of cysteine proteases and renin, and additional examples of peptidomimetic inhibitors of interleukin-1 beta-converting enzyme, neutral endopeptidase, herpes simplex virus protease, thrombin, HIV protease ...
A S, Ripka, D H, Rich
openaire +2 more sources
Major discoveries have been made of new type-I and type-III peptidomimetic inhibitors of peptide-derived systems. Innovative reversible inhibitors of cysteine proteases and renin, and additional examples of peptidomimetic inhibitors of interleukin-1 beta-converting enzyme, neutral endopeptidase, herpes simplex virus protease, thrombin, HIV protease ...
A S, Ripka, D H, Rich
openaire +2 more sources
2003
Highly selective and specific protein-protein and peptide-protein interactions are elicited by a large number of natural specific biological responses. The mimicry of these natural interactions has been an important and useful strategy for the development of metabolically stable drugs capable of being administered orally (1-4).
B S, Fulton +3 more
openaire +2 more sources
Highly selective and specific protein-protein and peptide-protein interactions are elicited by a large number of natural specific biological responses. The mimicry of these natural interactions has been an important and useful strategy for the development of metabolically stable drugs capable of being administered orally (1-4).
B S, Fulton +3 more
openaire +2 more sources
Formylated polyamines as peptidomimetics
Bioorganic & Medicinal Chemistry Letters, 2012A new construct for imitating a natural peptide ligand using a modified retro-inverso sequence is described. It is demonstrated through the synthesis of a peptidomimetic derived from the endogenous sequence of leucine enkephalin. The product was active at 400 nM and selective for μ-opioid receptors.
Sacha, Javor +5 more
openaire +2 more sources
Peptidomimetics in cancer chemotherapy
Clinical and Translational Oncology, 2007A summary of the current status of the application of peptidomimetics in cancer therapeutics as an alternative to peptide drugs is provided. Only compounds that are used in therapy or at least under clinical trials are discussed, using inhibitors of farnesyltransferase, proteasome and matrix metalloproteinases as examples.
C, Avendaño, J C, Menéndez
openaire +2 more sources
Minimalist and universal peptidomimetics
Chemical Society Reviews, 2011Many "new generation" peptidomimetics are designed to present amino acid side chains only; they do not have structural features that resemble peptide main chains. These types of molecules have frequently been presented in the literature as mimics of specific secondary structures.
Eunhwa, Ko, Jing, Liu, Kevin, Burgess
openaire +2 more sources
Synthesis of oligopeptide and peptidomimetic libraries
Current Opinion in Chemical Biology, 1997The elaboration of peptide libraries prepared by either chemical or biological methods in a format useful for discovery of peptides with specific biological activities was first introduced in the 1980s. A virtual explosion of activity in this area has occurred recently, and the basic approaches have been applied to a wide variety of chemistries and for
V J, Hruby, J M, Ahn, S, Liao
openaire +2 more sources
Oxetanyl Amino Acids for Peptidomimetics
Organic Letters, 2017Peptides are important in the drug discovery process. In analogy to nonpeptidic small-molecule counterparts, they can sometimes suffer from disadvantages such as their low bioavailability and poor metabolic stability. Herein, we report the synthesis of new oxetanyl dipeptides and their incorporation into Leu-enkephalin analogues as proof-of-principle ...
Guido P. Möller +6 more
openaire +2 more sources