Results 171 to 180 of about 14,095 (224)
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Current Opinion in Chemical Biology, 1998
Major discoveries have been made of new type-I and type-III peptidomimetic inhibitors of peptide-derived systems. Innovative reversible inhibitors of cysteine proteases and renin, and additional examples of peptidomimetic inhibitors of interleukin-1 beta-converting enzyme, neutral endopeptidase, herpes simplex virus protease, thrombin, HIV protease ...
A S, Ripka, D H, Rich
openaire +2 more sources
Major discoveries have been made of new type-I and type-III peptidomimetic inhibitors of peptide-derived systems. Innovative reversible inhibitors of cysteine proteases and renin, and additional examples of peptidomimetic inhibitors of interleukin-1 beta-converting enzyme, neutral endopeptidase, herpes simplex virus protease, thrombin, HIV protease ...
A S, Ripka, D H, Rich
openaire +2 more sources
2003
Highly selective and specific protein-protein and peptide-protein interactions are elicited by a large number of natural specific biological responses. The mimicry of these natural interactions has been an important and useful strategy for the development of metabolically stable drugs capable of being administered orally (1-4).
B S, Fulton +3 more
openaire +2 more sources
Highly selective and specific protein-protein and peptide-protein interactions are elicited by a large number of natural specific biological responses. The mimicry of these natural interactions has been an important and useful strategy for the development of metabolically stable drugs capable of being administered orally (1-4).
B S, Fulton +3 more
openaire +2 more sources
Formylated polyamines as peptidomimetics
Bioorganic & Medicinal Chemistry Letters, 2012A new construct for imitating a natural peptide ligand using a modified retro-inverso sequence is described. It is demonstrated through the synthesis of a peptidomimetic derived from the endogenous sequence of leucine enkephalin. The product was active at 400 nM and selective for μ-opioid receptors.
Sacha, Javor +5 more
openaire +2 more sources
Peptidomimetics in cancer chemotherapy
Clinical and Translational Oncology, 2007A summary of the current status of the application of peptidomimetics in cancer therapeutics as an alternative to peptide drugs is provided. Only compounds that are used in therapy or at least under clinical trials are discussed, using inhibitors of farnesyltransferase, proteasome and matrix metalloproteinases as examples.
C, Avendaño, J C, Menéndez
openaire +2 more sources
Human Defensin-Inspired Discovery of Peptidomimetic Antibiotics
Proceedings of the National Academy of Sciences of the United States of America, 2022Jue Zhang, Xiangming Fang, Baoli Cheng
exaly
QSAR Modelling of Peptidomimetic Derivatives Towards HKU4-CoV 3CLpro Inhibitors Against MERS-CoV
Chemistry, 2021Mohamed Bakhouch, Samir Chtita
exaly
Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer
Cancer Cell, 2017Irfan Asangani +2 more
exaly