Results 161 to 170 of about 14,095 (224)

Machine Learning-Guided Repositioning of a SARS-CoV-2-Targeting Molecular Series as Cruzain Inhibitors. [PDF]

ChemMedChem
Lameiro RF, Barbosa LF, Cardoso ER, Ho BS, Martins FCP, de Melo BC, Rosini F, Shamim A, Souza PM, de Souza WF, Montanari CA.   +10 more
europepmc   +1 more source

Peptidomimetic α,β-Unsaturated Ethyl Esters Are Irreversible Inactivators of Human Cathepsin L and Are Potent Inhibitors of SARS-CoV-2 in Cellular Models of COVID-19. [PDF]

J Med Chem
Kumar V, Drelich A, Chenna BC, Rademacher A, Kemp AM, Bishop AC, Saenkham-Huntsinger P, Scott E, Wand AJ, Laganowsky A, Tseng CT, Meek TD.   +11 more
europepmc   +1 more source

In Vitro synergy of Farnesyltransferase inhibitors in combination with colistin against ESKAPE bacteria. [PDF]

PLoS One
Klose M, Weber L, Bachmann HS.
europepmc   +1 more source

Cationic Peptoids for Systemic In Vivo Cartilage-Targeting. [PDF]

Adv Sci (Weinh)
Zhang C, Qiu R, Huang Y, Liu Y, Huang K, Zhao S, Li Y.   +6 more
europepmc   +1 more source

Protein farnesylation: from molecular mechanisms to therapeutic targeting in cancer, aging, and beyond. [PDF]

Front Pharmacol
Lou J, Zhang D, Wang Y.
europepmc   +1 more source

A CYFIP1-Inspired Peptidomimetic Modulates eIF4E-Dependent Translational Control in Cancer and Neurodevelopmental Disorders

Romagnoli A, Alsina O, Raniolo S, Gori A, Foka K, De Luca A, Sgrignani J, Rexha J, Roscioni A, Bergamaschi G, Boussadia Z, Pepponi R, Venturini G, Cavalli A, Borsello T, Martire A, La Teana A, Bagni C, Di Marino D, Limongelli V.   +19 more
europepmc   +1 more source

Fat or flat? The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules.

Inorg Chem Front
Holub J, Jílková A, Lemke C, Cianni L, Spiwoková P, Horn M, Breuer C, Leontovyč A, Brynda J, Mertlíková-Kaiserová H, Chanová M, Dos Reis Rocho F, Montanari CA, El-Sakkary N, Caffrey CR, Gütschow M, Hnyk D, Mareš M, Fanfrlík J.   +18 more
europepmc   +1 more source

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Peptidomimetics in Silico

Molecular Informatics, 2020
AbstractEndogenous peptides as part of physiological processes are targets of interest when it comes to finding desirable therapeutics which are able to modulate molecular interactions. The major limits presented by peptides when they are used as drugs have motivated the research of the synthesis of peptidomimetics obtained through chemical ...
Tomasella Cristina, Floris Matteo, Guccione Salvatore, Pappalardo Matteo, Basile Livia   +4 more
openaire   +3 more sources

Peptidomimetics and Angiogenesis

Mini-Reviews in Medicinal Chemistry, 2002
Angiogenesis is the sprouting of new blood capillaries from surrounding preexisting blood vessels. This process is fundamental for embryonic development, wound healing and inflammation. In healthy adults angiogenesis is of minor importance. However, aberrant angiogenesis is essentially involved in disorders as diabetic retinopathy, rheumatoid arthritis
Ralph, Mazitschek, Patrick, Baumhof, Athanassios, Giannis   +2 more
openaire   +2 more sources

Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies [PDF]

Pharmaceuticals, 2021
Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and ...
Mark J Kurth, Aizhan Abdildinova, Young-Dae Gong   +2 more
exaly   +2 more sources