Results 161 to 170 of about 17,763 (235)

Engineered cyclic peptide targeting ITGA5 disrupts tumor-stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma. [PDF]

Acta Pharm Sin B
Mardhian DF, Pednekar KP, Hemdan AG, Kuninty PR, Karim SA, de Winter S, Metselaar JM, Morton JP, Prakash J.   +8 more
europepmc   +1 more source

5‑Amino-5-deoxyshikimic Acid as a Versatile γ‑Amino Acid for Peptidomimetic Synthesis. [PDF]

ACS Omega
Suć Sajko J, Pahović F, Jerić I.
europepmc   +1 more source

Inhibition of LIMK by Cofilin-1 peptidomimetics enhances actin depolymerization and reduces metastasis of non-small cell lung cancer. [PDF]

Oncogenesis
Lin MY, Leu JD, Wu CY, Chen LC, Lee YJ.
europepmc   +1 more source

Unlocking Enol-Ugi-Derived Conformationally Restricted Peptidomimetic Motifs. [PDF]

J Org Chem
Ramiro JL, Díaz J, G Neo A, F Marcos C.
europepmc   +1 more source

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Peptidomimetic Polyurethanes Inhibit Bacterial Biofilm Formation and Disrupt Surface Established Biofilms.

Journal of the American Chemical Society, 2021
Over 80% of all chronic bacterial infections in humans are associated with biofilms, which are surface-associated bacterial communities encased within a secreted exopolysaccharide matrix that can provide resistance to environmental and chemical insults ...
Apoorva Vishwakarma, F. Dang, Allison Ferrell, Hazel A. Barton, Abraham Joy   +4 more
semanticscholar   +1 more source

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability

Journal of Medicinal Chemistry, 2021
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a necessity to develop direct-acting antivirals that can be readily administered and are active against a broad spectrum of coronaviruses.
Bing Bai, Alexandr Belovodskiy, Mostofa A Hena, Appan Srinivas Kandadai, Michael A. Joyce, H. Saffran, Justin A. Shields, Muhammad Bashir Khan, E. Arutyunova, Jimmy Lu, Sardeev K Bajwa, D. Hockman, Conrad Fischer, Tess Lamer, Wayne Vuong, M. J. van Belkum, Z. Gu, F. Lin, Yanhua Du, Jia Xu, M. Rahim, H. Young, J. Vederas, D. Tyrrell, M. J. Lemieux, J. Nieman   +25 more
semanticscholar   +1 more source

Peptidomimetic Wet-Adhesive PEGtides with Synergistic and Multimodal Hydrogen Bonding.

Journal of the American Chemical Society, 2022
The remarkable underwater adhesion of mussel foot proteins has long been an inspiration in the design of peptidomimetic materials. Although the synergistic wet adhesion of catechol and lysine has been recently highlighted, the critical role of the ...
Minseong Kim, Jin-Sup Park, Kyung Min Lee, Eeseul Shin, S. Park, Joonhee Lee, Chanoong Lim, S. Kwak, Dong Woog Lee, Byeong‐Su Kim   +9 more
semanticscholar   +1 more source

Peptidomimetics in Silico

Molecular Informatics, 2020
AbstractEndogenous peptides as part of physiological processes are targets of interest when it comes to finding desirable therapeutics which are able to modulate molecular interactions. The major limits presented by peptides when they are used as drugs have motivated the research of the synthesis of peptidomimetics obtained through chemical ...
Tomasella Cristina, Floris Matteo, Guccione Salvatore, Pappalardo Matteo, Basile Livia   +4 more
openaire   +3 more sources

Peptidomimetic toolbox for drug discovery.

Chemical Society Reviews, 2020
The art of transforming peptides into drug leads is still a dynamic and fertile field in medicinal chemistry and drug discovery. Peptidomimetics can respond to peptide limitations by displaying higher metabolic stability, good bioavailability and ...
E. Lenci, A. Trabocchi
semanticscholar   +1 more source

Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity.

Journal of the American Chemical Society, 2021
An interruption in Aβ homeostasis leads to the deposit of neurotoxic amyloid plaques and is associated with Alzheimer's disease. A supramolecular strategy based on the assembly of peptidomimetic agents into functional vesicles has been conceived for the ...
D. Maity, Madeline Howarth, M. Vogel, M. Magzoub, A. Hamilton   +4 more
semanticscholar   +1 more source