Results 101 to 110 of about 1,668 (171)

Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis

, 2011
ObjectiveTo define the relationship between autoantigen citrullination and different peptidylarginine deiminase (PAD) enzymes in rheumatoid arthritis (RA).MethodsCitrullinated autoantigens were identified by immunoblotting control and ionomycin-activated
Erika Darrah, Jon T Giles, Felipe Andrade, Antony Rosen   +3 more
core   +1 more source

Peptidylarginine deiminase is involved in maintaining the cornified oral mucosa of rats.

, 2018
福岡歯科大学博士（歯学）2018年度Epithelial cells derived from different regions exhibit marked differences in their differentiation capacity, allowing them to provide a suitable protective barrier.
T. Kita, Arita, Seiichi, R. Sakagami, S. Arita, Kita, Tomo, T. Ryu, Hatta, Mitsutoki, Okamura, Kazuhiko, Yamazaki, Jun, J. Yamazaki, K. Uchida, M. Hatta, H. Murakami, Uchida, Kunitoshi, Murakami, Hiroshi, K. Okamura, Ryu, Takanori, Sakagami, Ryuji   +17 more
core   +1 more source

Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva

, 2013
BACKGROUND AND OBJECTIVE The presence of citrullinated proteins, and peptidylarginine deiminase types -2 (PAD-2) and -4 (PAD-4) in periodontal tissues, determine the presence of anti-cyclic citrullinated protein antibodies (anti-CCP) in gingival ...
Marchant, C., Bartold, P., Dharmapatni, A., Fitzsimmons, T., Harvey, G., Haynes, D.   +5 more
core   +1 more source

Pathogenesis of autoimmune diseases: antibodies against transglutaminase, peptidylarginine deiminase and protein-bound citrulline in primary Sjögren's syndrome, multiple sclerosis and Alzheimer's disease.

, 2008
Coeliac disease (CD) is becoming a model for understanding the pathogenesis of autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific residues of gliadins have been identified.
P. Stenberg, E. Bodil Roth, Larsson, A, Roth, Bodil, Sandberg Wollheim, Magnhild, Londos, Elisabet, K. Sjöberg, Sjöberg, Klas, Stenberg, Peter, Å. Larsson, Theander, Elke, M. Sandberg-Wollheim, E. Theander, E. Londos   +13 more
core   +1 more source

Cell-free DNA in sepsis: from molecular insights to clinical management

Military Medical Research
Sepsis is a dysregulated host response to infection that frequently results in fatal multiple organ dysfunction. Despite advances in clinical identification and management, both its incidence and mortality have remained persistently high.
Lei Li, Hong-Chao Huang, Yin He, Jia-Yue-Cheng Pang, Shi-Chu Xiao, Zhao-Fan Xia, Yong-Jun Zheng   +6 more
doaj   +1 more source

Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages.

, 2004
BACKGROUND: Antibodies directed to proteins containing the non-standard amino acid citrulline, are extremely specific for rheumatoid arthritis (RA). Peptidylcitrulline can be generated by post-translational conversion of arginine residues.
Mansum, M.A. van, Dieteren, C.E.J., Zendman, A.J.W., Venrooij, W.J.W. van, Heijden, A.G. van der, Vossenaar, E.R., Barrera Rico, P., Radstake, T.R.D.J., Rooij, D.J.R.A.M. de   +8 more
core  

A highly sensitive assay method for peptidylarginine deiminase (PAD) and its application

Japanese Journal of Pharmacology, 2000
Takeshi Kato, Ayumi Tsuda, Masaru Yamamoto, Michiyuki Yamada, Ryuichi Yajima, Toshiyuki Chikuma   +5 more
openaire   +1 more source

Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model

Molecular Medicine
Following cerebral ischemia, neutrophil extracellular traps (NETs) contribute significantly to brain damage by exacerbating delayed immune cell infiltration and vascular injury. They are detected both in brain tissue and within blood vessels.
Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee   +4 more
doaj   +1 more source

IL-8 (chemokine (C-X-C motif) ligand 8; CXCL8); peptidylarginine deiminase (PAD) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Regulation of basal and tumour necrosis factor α-induced fibroblast gene expression by peptidylarginine deiminase 2. [PDF]

J Physiol
Saifi MA, Marguerie F, Kamiya M, Nguyen HN, Knipe RS, Kim EY, Ho IC.   +6 more
europepmc   +1 more source