Results 81 to 90 of about 1,668 (171)

Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes

, 2012
The antigenic targets of the rheumatoid arthritis (RA)-associated autoantibodies to "citrullinated" proteins are generated following citrullination by a peptidylarginine deiminase (PAD). Of the five PAD isotypes, two - PAD2 and PAD4 - are expressed in RA
Serre, Guy, Dayer, Jean-Michel, Foulquier, Céline, Sebbag, Mireille, Chicheportiche, Rachel, Ferrari-Lacraz, Sylvie   +5 more
core   +1 more source

Cancer Cell‐Derived Large Extracellular Vesicles Promote Venous Thromboembolism by Activating NETosis Through Delivering CYBA

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Venous thromboembolism (VTE) is a major threat to cancer patients. Cancer‐derived large extracellular vesicles deliver CYBA (p22phox) to neutrophils, triggering reactive oxygen species (ROS) and citrullinated histone H3 (citH3) formation. This drives neutrophil extracellular traps formation (NETosis), elevating VTE risk.
Xiangji Li, Yingjiao Ju, Chenjie Xu, Shixiang Ma, Lan Sun, Qingdong Guo, Mingyuan Liu, Yibin Xie, Li Min   +8 more
wiley   +1 more source

GnRH Stimulates Peptidylarginine Deiminase Catalyzed Histone Citrullination in Gonadotrope Cells

, 2017
Peptidylarginine deiminase (PAD) enzymes convert histone tail arginine residues to citrulline resulting in chromatin decondensation. Our previous work found that PAD isoforms are expressed in female reproductive tissues in an estrous cycle-dependent ...
Muth, Aaron, Thompson, Paul R, Navratil, Amy M., Khan, Shaihla A., Cherrington, Brian D., Edwards, Brian S.   +5 more
core   +1 more source

Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release? [PDF]

, 2017
Exosomes and microvesicles (EMVs) are lipid bilayer-enclosed structures released from cells and participate in cell-to-cell communication via transport of biological molecules.
Inal, JM, Jameel Inal, Sigrun Lange, Lange, S, Mariya Hristova, Kholia, S., Hristova, Mariya, Inal, J.M., Hardy, John, John Hardy, Lange, Sigrun, Hardy, J, Hardy, J., Hristova, M., Gallagher, Mark, Uchini Kosgodage, Kholia, Sharad, Kosgodage, U., Lange, S., Inal, Jameel M, Gallagher, M, Kosgodage, US, Kosgodage, Uchini S, Kholia, S, Hristova, M, Mark Gallagher, Sharad Kholia   +26 more
core   +1 more source

Periodontal sources of citrullinated antigens and TLR agonists related to RA

Autoimmunity, 2018
Anti-citrullinated protein autoantibodies (ACPA) precede the onset of clinical and subclinical rheumatoid arthritis (RA). ACPA are frequently generated in further chronic inflammatory diseases, e.g.
Ljubomir Vitkov, Matthias Hannig, Bernd Minnich, Martin Herrmann   +3 more
doaj   +1 more source

The Role of Cutaneous B‐Cells in Hidradenitis Suppurativa: From Preclinical Evidence to Novel Targeted Therapies

Experimental Dermatology, Volume 34, Issue 9, September 2025.
ABSTRACT Hidradenitis Suppurativa (HS) is a chronic autoinflammatory skin disease of the terminal hair follicle, whose pathogenesis is complex and multifactorial. Alongside a predisposing genetic background, environmental/epigenetic factors, alterations in the skin microbiome, and dysregulation of both innate and adaptive immune responses contribute to
Maurizio Romagnuolo, Laura Calabrese, Martina D'Onghia, Vittoria Cioppa, Pietro Rubegni, Angelo Valerio Marzano, Chiara Moltrasio   +6 more
wiley   +1 more source

Transglutaminase and peptidylarginine deiminase in the pathogenesis of autoimmune diseases [PDF]

, 2008
Coeliac disease (CD) is becoming a model for understanding the pathogenesis of autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific glutamine residues of gliadins have been identified.
Roth, Bodil
core  

Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2019
Background Tamoxifen resistance presents a huge clinical challenge for breast cancer patients. An understanding of the mechanisms of tamoxifen resistance can guide development of efficient therapies to prevent drug resistance.
Fujun Li, Lixia Miao, Teng Xue, Hao Qin, Santanu Mondal, Paul R. Thompson, Scott A. Coonrod, Xiaoqiu Liu, Xuesen Zhang   +8 more
doaj   +1 more source

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury

Advanced Science, Volume 12, Issue 18, May 15, 2025.
Peptidyl arginine deiminase 2 (PAD2) plays a key role in regulating macrophage function in Pseudomonas aeruginosa‐induced acute lung injury (ALI). Using single‐cell RNA sequencing and proteomics, a new PAD2‐catalyzed citrullination site on NF‐κB p65 (171 Arginine), modulating macrophage polarization is identified.
Xin Yu, Yujing Song, Tao Dong, Wenlu Ouyang, Chao Quan, Liujiazi Shao, Leonard Barasa, Paul R. Thompson, Mao Zhang, Jianjie Ma, Katsuo Kurabayashi, Yongqing Li   +11 more
wiley   +1 more source

Peptidylarginine deiminase and deiminated proteins are detected throughout early halibut ontogeny - Complement components C3 and C4 are post-translationally deiminated in halibut (Hippoglossus hippoglossus L.) [PDF]

, 2019
Post-translational protein deimination is mediated by peptidylarginine deiminases (PADs), which are calcium dependent enzymes conserved throughout phylogeny with physiological and pathophysiological roles. Protein deimination occurs via the conversion of
Bowden, T., Birkir Thor Bragason, Bricknell, Ian, Ian R. Bricknell, Alister W. Dodds, Dodds, A.W., Sigrun Lange, Lange, S, Mariya Hristova, Hristova, Mariya, Bragason, Birkir, Bowden, Timothy, Bragason, B.T., Dodds, Alister W., Anthony P. Nicholas, Magnadóttir, B, Lange, Sigrun, Timothy Bowden, Magnadottir, Bergljot, Dodds, AW, Hristova, M., Bragason, BT, Nicholas, AP, Bergljót Magnadóttir, Bricknell, I.R., Gudmundsdottir, S., Bowden, T, Bricknell, IR, Lange, S., Nicholas, A.P., Nicholas, Anthony P., Hristova, M, Guðmundsdóttir, S, Guðmundsdóttir, Sigríður, Magnadóttir, B., Sigríður Guðmundsdóttir   +35 more
core   +1 more source