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Extracellular Vesicles (EVs) in Tumor Diagnosis and Therapy. [PDF]

Technol Cancer Res Treat, 2023
In recent years, extracellular vesicles (EVs) have gained significant attention due to their tremendous potential for clinical applications. EVs play a crucial role in various aspects, including tumorigenesis, drug resistance, immune escape, and ...
Tan M, Ge Y, Wang X, Wang Y, Liu Y, He F, Teng H.   +6 more
europepmc   +5 more sources

The Methods of Choice for Extracellular Vesicles (EVs) Characterization [PDF]

International Journal of Molecular Sciences, 2017
In recent years, extracellular vesicles (EVs) have become a subject of intense study. These membrane-enclosed spherical structures are secreted by almost every cell type and are engaged in the transport of cellular content (cargo) from parental to target
Maciej Siedlar, Monika Baj-Krzyworzeka, Małgorzata Lekka   +2 more
exaly   +5 more sources

New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs). [PDF]

Theranostics, 2023
Neurodegenerative diseases are characterized by the progressive loss of neurons and intricate interactions between different cell types within the affected regions.
Palanisamy CP, Pei J, Alugoju P, Anthikapalli NVA, Jayaraman S, Veeraraghavan VP, Gopathy S, Roy JR, Janaki CS, Thalamati D, Mironescu M, Luo Q, Miao Y, Chai Y, Long Q.   +14 more
europepmc   +2 more sources

High Yield, Scalable and Remotely Drug-Loaded Neutrophil-Derived Extracellular Vesicles (EVs) for Anti-Inflammation Therapy

Biomaterials, 2017
Extracellular vesicles (EVs) are nanoscale membrane-formed compartments naturally secreted from cells, which are intercellular mediators regulating physiology and pathogenesis, therefore they could be a novel therapeutic carrier for targeted delivery ...
Jin Gao, Zhenjia Wang, Sihan Wang
exaly   +2 more sources

Proteomic Characterisation of Leech Microglia Extracellular Vesicles (EVs): Comparison Between Differential Ultracentrifugation and Optiprep™ Density Gradient Isolation

Journal of Extracellular Vesicles, 2019
In Mammals, microglial cells are considered as the resident immune cells in central nervous system (CNS). Many studies demonstrated that, after injury, these cells are activated and recruited at the lesion site.
Soulaimane Aboulouard, Christophe Lefebvre, Jacopo Vizioli   +2 more
exaly   +2 more sources

Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles

Pharmacological Research
Extracellular vesicles (EVs) are tiny lipid bilayer-enclosed membrane particles released from a variety of cell types into the surrounding environment. These EVs have massive participated in cell-to-cell communication and interspecies communication.
Siyu Hao, Hongyu Yang, Jiaojiao Hu, Lili Luo, Yuan Yuan, Libing Liu   +5 more
doaj   +2 more sources

Gastric Cancer-Derived Extracellular Vesicles (EVs) Promote Angiogenesis via Angiopoietin-2 [PDF]

Cancers, 2022
Eran Nizri, Osnat Sher, Shelly Loewenstein   +2 more
exaly   +2 more sources

Coincubation as miR-Loading Strategy to Improve the Anti-Tumor Effect of Stem Cell-Derived EVs

Pharmaceutics, 2021
Extracellular vesicles are considered a novel therapeutic tool, due to their ability to transfer their cargoes to target cells. Different strategies to directly load extracellular vesicles with RNA species have been proposed.
Alessia Brossa, Marta Tapparo, Valentina Fonsato, Elli Papadimitriou, Michela Delena, Giovanni Camussi, Benedetta Bussolati   +6 more
doaj   +1 more source

Small Extracellular Vesicles: A Novel Avenue for Cancer Management

Frontiers in Oncology, 2021
Extracellular vesicles are small membrane particles derived from various cell types. EVs are broadly classified as ectosomes or small extracellular vesicles, depending on their biogenesis and cargoes.
Yanan Gao, You Qin, Chao Wan, Yajie Sun, Jingshu Meng, Jing Huang, Yan Hu, Honglin Jin, Kunyu Yang   +8 more
doaj   +1 more source

MiR-146a-5p delivered by hucMSC extracellular vesicles modulates the inflammatory response to sulfur mustard-induced acute lung injury

Stem Cell Research & Therapy, 2023
Background Sulfur mustard (SM) is a highly toxic chemical warfare agent that has caused numerous casualties during wars and conflicts in the past century. Specific antidotes or therapeutic strategies are rare due to the complicated mechanism of toxicity,
Zhipeng Pei, Jinfeng Cen, Xinkang Zhang, Chuchu Gong, Mingxue Sun, Wenqi Meng, Guanchao Mao, Jingjing Wan, Bingyue Hu, Xiaowen He, Qingqiang Xu, Hua Han, Kai Xiao   +12 more
doaj   +1 more source